A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) (COPERNICUS)

Last Updated   May 1, 2025

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61186372NSC2012

OVERVIEW

  • Sexes Eligible for Study
    all
  • Age
    18+ years
  • Phase
    phase 2
    2
  • Sites
    39 Sites
  • Status
     Recruiting

SUMMARY

The primary purpose of the study is to assess how well amivantamab subcutaneous (SC) administration in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC; that is one of the major types of lung cancer).

CONDITIONS

  • Carcinoma, Non-Small-Cell Lung

ELIGIBILITY


Inclusion Criteria:

* Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC) that is not amenable to curative intent therapy
* Epidermal growth factor resistance-mutation (EGFRm) must be an Ex19del or Ex21 L858R substitution, as d

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DETAILS

LOCATIONS

Locations in:
United States, Puerto Rico
Country (2) City or Province (39) Status
United States Los Alamitos Cancer and Blood Specialty Clinic
RECRUITING
United States Santa Rosa Providence Medical Foundation
RECRUITING
United States Hinsdale Hope and Healing Cancer Services
RECRUITING
United States Wilson Regional Medical Oncology Center
RECRUITING
United States El Paso Renovatio Clinical
RECRUITING
United States Kingwood Community Clinical Trials
RECRUITING
United States The Woodlands Renovatio Clinical
RECRUITING
United States Fullerton Providence Medical Foundation
RECRUITING
United States Glendale The Oncology Institute of Hope and Innovation
RECRUITING
United States Glendale Oncology Physicians Network Healthcare
RECRUITING
United States Glendale Los Angeles Cancer Network
RECRUITING
United States Los Angeles USC Norris Comprehensive Cancer Center
RECRUITING
United States Los Angeles Cedars Sinai Medical Center
RECRUITING
United States Los Angeles Valkyrie Clinical Trials
RECRUITING
United States Orange St. Joseph Hospital Center for Cancer Prevention and Treatment
RECRUITING
United States Walnut Creek John Muir Health Clinical Research Center
RECRUITING
United States New Haven Yale New Haven Hospital Yale Cancer Center
RECRUITING
United States Orlando Orlando Health Cancer Institute
RECRUITING
United States Atlanta Piedmont Healthcare
RECRUITING
United States Atlanta Piedmont Cancer Institute
RECRUITING
United States Atlanta Winship Cancer Institute Emory University
RECRUITING
United States Noblesville Investigative Clinical Research of Indiana, LLC
RECRUITING
United States Ames Accellacare of McFarland
RECRUITING
United States Ypsilanti Trinity Health St Joseph Mercy Ann Arbor
RECRUITING
United States Minneapolis University Of Minnesota
RECRUITING
United States Jackson Jackson Oncology Associates
RECRUITING
United States Saint Louis Washington University School Of Medicine
RECRUITING
United States Flemington Hunterdon Hematology Oncology
RECRUITING
United States New Brunswick Rutgers Cancer Institute of New Jersey
RECRUITING
United States New York NYU Langone Health Laura and Isaac Perlmutter Cancer Center
RECRUITING
United States New York Herbert Irving Comprehensive Cancer Center Columbia University Medical Center
RECRUITING
United States Schenectady Ellis Hospital
RECRUITING
United States Westbury Clinical Research Alliance Inc
RECRUITING
United States Sioux Falls Avera Medical Group
RECRUITING
United States Memphis Baptist Cancer Center
RECRUITING
United States Dallas UT Southwestern Medical Center
RECRUITING
United States Fort Worth JPS Health Network
RECRUITING
United States Spokane Summit Cancer Centers
RECRUITING
Puerto Rico San Juan Auxilio Mutuo Cancer Center
RECRUITING
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Geo Locations

33.80307, -118.07256

38.44047, -122.71443

41.80086, -87.93701

35.72127, -77.91554

31.75872, -106.48693

30.03355, -95.26104

30.15799, -95.48938

33.87029, -117.92534

34.14251, -118.25508

34.14251, -118.25508

34.14251, -118.25508

34.05223, -118.24368

34.05223, -118.24368

34.05223, -118.24368

33.78779, -117.85311

37.90631, -122.06496

41.30815, -72.92816

28.53834, -81.37924

33.749, -84.38798

33.749, -84.38798

33.749, -84.38798

40.04559, -86.0086

42.03471, -93.61994

42.24115, -83.61299

44.97997, -93.26384

32.29876, -90.18481

38.62727, -90.19789

40.51233, -74.85933

40.48622, -74.45182

40.71427, -74.00597

40.71427, -74.00597

42.81424, -73.93957

40.75566, -73.58763

43.54997, -96.70033

35.14953, -90.04898

32.78306, -96.80667

32.72541, -97.32085

47.65966, -117.42908

18.46633, -66.10572

x
50

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10

Indicates 10+ sites in this region: click to zoom in.

5

Indicates < 10 sites in this region: click to zoom in.

Corresponds to individual site.

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