A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia (TAILOR)
Last Updated May 14, 2025
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54179060CLL2032
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 22 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to evaluate the efficacy and safety of ibrutinib + venetoclax (I+V) and ibrutinib monotherapy regimens in which dosing of ibrutinib is either proactively reduced or reactively modified in response to adverse events (AEs).
CONDITIONS
- Leukemia, Lymphocytic, Chronic, B-Cell
- Small Lymphocytic Lymphoma
ELIGIBILITY
Inclusion Criteria:
* Diagnosis of chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL/SLL) as per International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2018 diagnostic criteria
* For ibruinib + venetocIax (I+V) cohorts: eastern cooperative oncology group (ECOG
DETAILS
LOCATIONS
Locations in:
United States, Canada, Czechia, France, Hungary, Italy, Poland, Spain
| Country (8) | City or Province (74) | Status |
| United States | Cerritos The Oncology Institute Clinical Research |
RECRUITING
|
| United States | San Luis Obispo SLO Oncology and Hematology Health Center |
RECRUITING
|
| United States | Santa Rosa Providence Medical Foundation |
RECRUITING
|
| United States | Whittier PIH Health Hospital |
RECRUITING
|
| United States | Grand Junction Grand Valley Oncology |
RECRUITING
|
| United States | Miami Beach Mount Sinai Medical Center Campus |
RECRUITING
|
| United States | Hinsdale Hope and Healing Cancer Services |
RECRUITING
|
| United States | Springfield Springfield Clinic |
RECRUITING
|
| United States | Iowa City Iowa City VA Health Care System |
RECRUITING
|
| United States | Kansas City Research Medical Center |
RECRUITING
|
| United States | Flemington Hunterdon Hematology Oncology |
RECRUITING
|
| United States | Nyack Hematology Oncology Associates of Rockland |
RECRUITING
|
| United States | Cincinnati Oncology Hematology Care |
RECRUITING
|
| United States | Eugene Willamette Valley Cancer Institute and Research Center |
RECRUITING
|
| United States | Fort Worth Texas Oncology-Fort Worth Cancer Center |
RECRUITING
|
| United States | The Woodlands Texas Oncology-Gulf Coast |
RECRUITING
|
| United States | Ogden Community Cancer Trials of Utah |
RECRUITING
|
| United States | Virginia Beach Virginia Oncology Associates |
RECRUITING
|
| United States | Seattle VA Puget Sound Healthcare System |
RECRUITING
|
| United States | Vancouver Northwest Cancer Specialists PC |
RECRUITING
|
| Canada | Halifax QEII Health Sciences Centre |
RECRUITING
|
| Canada | St. Catharines Niagara Health System |
RECRUITING
|
| Czechia | Brno - Bohunice Fakultni nemocnice Brno |
RECRUITING
|
| Czechia | Hradec Kralove Fakultni nemocnice Hradec Kralove |
RECRUITING
|
| Czechia | Olomouc Fakultni nemocnice Olomouc |
RECRUITING
|
| Czechia | Ostrava - Poruba Fakultni Nemocnice Ostrava |
RECRUITING
|
| Czechia | Praha 10 Fakultni nemocnice Kralovske Vinohrady |
RECRUITING
|
| Czechia | Praha 2 Ustav Hematologie A Krevni Transfuze |
RECRUITING
|
| France | Clermont-Ferrand CHU de Clermont Ferrand |
RECRUITING
|
| France | Nantes Cedex 1 CHU Nantes |
RECRUITING
|
| France | Paris cedex 13 Hopital Pitie Salpetriere |
RECRUITING
|
| France | Pierre-Benite CHU Lyon Sud |
RECRUITING
|
| France | Reims CHU de Reims |
RECRUITING
|
| France | Strasbourg Institut de Cancerologie Strasbourg Europe ICANS |
RECRUITING
|
| Hungary | Budapest Semmelweis Egyetem |
RECRUITING
|
| Hungary | Gyor Gyor Moson Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz |
RECRUITING
|
| Hungary | Nyiregyhaza Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz |
RECRUITING
|
| Italy | Ferrara Azienda Ospedaliero-Universitaria di Ferrara Arcispedale Sant Anna |
RECRUITING
|
| Italy | Firenze Azienda Ospedaliero Universitaria Careggi |
RECRUITING
|
| Italy | Milano Ospedale San Raffaele |
RECRUITING
|
| Italy | Novara Ospedale Maggiore della Carita |
RECRUITING
|
| Italy | Palermo Ospedale Villa Sofia-Cervello |
RECRUITING
|
| Italy | Perugia Azienda Ospedaliera di Perugia Ospedale S.Maria della Misericordia |
RECRUITING
|
| Italy | Roma Ematologia Fondazione Univ. Policlinico Gemelli Università Cattolica del Sacro Cuore |
RECRUITING
|
| Italy | Roma Umberto I Policlinico di Roma |
RECRUITING
|
| Poland | Biala Podlaska Wojewodzki Szpital Specjalistyczny |
RECRUITING
|
| Poland | Gdynia Szpitale Pomorskie Sp z o o |
RECRUITING
|
| Spain | Barcelona Hosp Univ Vall D Hebron |
RECRUITING
|
| Spain | Cordoba Hosp Reina Sofia |
RECRUITING
|
| Spain | Madrid Hosp. Univ. 12 de Octubre |
RECRUITING
|
| Spain | Santander Hosp. Univ. Marques de Valdecilla |
RECRUITING
|
| Spain | Santiago de Compostela Hosp. Clinico Univ. de Santiago |
RECRUITING
|
| United States | Los Alamitos Cancer and Blood Specialty Clinic |
RECRUITING
|
| United States | North Miami Beach The Oncology Institute |
RECRUITING
|
| United States | Orange Mid Florida Hematology Oncology |
RECRUITING
|
| United States | Boise Boise VA Medical Center |
RECRUITING
|
| United States | Minneapolis Minnesota Oncology Hematology P A |
RECRUITING
|
| United States | Florham Park Summit Medical Group |
COMPLETED
|
| United States | Portland OHSU Knight Cancer Institute |
RECRUITING
|
| United States | El Paso Renovatio Clinical |
RECRUITING
|
| United States | Houston The University of Texas MD Anderson Cancer Center |
RECRUITING
|
| United States | The Woodlands Renovatio Clinical |
RECRUITING
|
| United States | Manassas Virginia Cancer Specialists |
RECRUITING
|
| Hungary | Szeged University of Szeged |
RECRUITING
|
| Italy | Bari U.O. Ematologia Istituto Tumori Giovanni Paolo II |
RECRUITING
|
| Italy | Milano ASST Grande Ospedale Metropolitano Niguarda |
RECRUITING
|
| Italy | Padova Universita degli Studi di Padova Azienda Ospedaliera di Pa |
RECRUITING
|
| Poland | Brzozow Szpital Specjalistyczny w Brzozowie |
RECRUITING
|
| Poland | Kielce Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach |
RECRUITING
|
| Poland | Krakow Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie |
RECRUITING
|
| Poland | Lodz Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi |
RECRUITING
|
| Poland | Lublin Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli |
RECRUITING
|
| Spain | Madrid Hosp. Univ. Ramon Y Cajal |
RECRUITING
|
| United States | Goldsboro Southeastern Medical Oncology Center |
COMPLETED
|
Geo Locations
33.85835, -118.06479
35.28275, -120.65962
38.44047, -122.71443
33.97918, -118.03284
39.06387, -108.55065
25.79065, -80.13005
41.80086, -87.93701
39.80172, -89.64371
41.66113, -91.53017
39.09973, -94.57857
40.51233, -74.85933
41.09065, -73.91791
39.12713, -84.51435
44.05207, -123.08675
32.72541, -97.32085
30.15799, -95.48938
41.223, -111.97383
36.85293, -75.97799
47.60621, -122.33207
45.63873, -122.66149
44.64533, -63.57239
43.17126, -79.24267
49.1693374, 16.5792118
50.20923, 15.83277
49.59552, 17.25175
49.83465, 18.28204
50.08804, 14.42076
50.08804, 14.42076
45.77966, 3.08628
47.21725, -1.55336
48.85341, 2.3488
45.7009, 4.82511
49.25, 4.03333
48.58392, 7.74553
47.49801, 19.03991
47.68333, 17.63512
47.95539, 21.71671
44.83804, 11.62057
43.77925, 11.24626
45.46427, 9.18951
45.44694, 8.62118
38.13205, 13.33561
43.1122, 12.38878
41.89193, 12.51133
41.89193, 12.51133
52.03238, 23.11652
54.51889, 18.53188
41.38879, 2.15899
37.89155, -4.77275
40.4165, -3.70256
43.46472, -3.80444
42.88052, -8.54569
33.80307, -118.07256
25.93315, -80.16255
30.2277, -85.02492
43.6135, -116.20345
44.97997, -93.26384
40.78788, -74.38821
45.52345, -122.67621
31.75872, -106.48693
29.76328, -95.36327
30.15799, -95.48938
38.75095, -77.47527
46.253, 20.14824
41.11148, 16.8554
45.46427, 9.18951
45.40797, 11.88586
49.69501, 22.01926
50.87033, 20.62752
50.06143, 19.93658
51.75, 19.46667
51.25, 22.56667
40.4165, -3.70256
35.38488, -77.99277
x
50
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10
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5
Indicates < 10 sites in this region: click to zoom in.
Corresponds to individual site.