A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms
Last Updated May 14, 2025
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88549968MPN1001
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 1 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to characterize safety and to determine the Recommended Phase 2 Dose (RP2D[s]) and optimal dosing schedule(s) of JNJ-88549968, in part 1 (Dose Escalation); to characterize the safety of JNJ- 88549968 at RP2D(s), in part 2 (Cohort Expansion).
CONDITIONS
- Myeloproliferative Disorders
- Essential Thrombocythemia
- Cancer
- Primary Myelofibrosis
ELIGIBILITY
Inclusion Criteria:
* Be greater than or equal to (>=) 18 years of age (or the legal age of majority in the jurisdiction in which the study is taking place, whichever the greater) at the time of informed consent
* Positive for a calreticulin (CALR) driver mutation of essential th
DETAILS
LOCATIONS
| Country (6) | City or Province (19) | Status |
| United States | Duarte City of Hope |
RECRUITING
|
| United States | Ann Arbor University of Michigan |
RECRUITING
|
| United States | Charlotte Levine Cancer Institute |
RECRUITING
|
| United States | Philadelphia University of Pennsylvania |
RECRUITING
|
| United States | Nashville Sarah Cannon Cancer Institute |
RECRUITING
|
| United States | Houston MD Anderson Cancer Center |
RECRUITING
|
| France | Paris Hopital Saint Louis |
RECRUITING
|
| France | Pierre Benite Cedex CH LYON SUD - Hematology |
RECRUITING
|
| Germany | Aachen Universitaetsklinikum der RWTH Aachen |
RECRUITING
|
| Spain | Badalona Hosp. Univ. Germans Trias I Pujol |
RECRUITING
|
| Spain | Valencia Hosp. Clinico Univ. de Valencia |
RECRUITING
|
| United Kingdom | London University College London Hospitals Nhs Foundation Trust |
RECRUITING
|
| United Kingdom | Oxford Churchill Hospital |
RECRUITING
|
| United States | Tampa Moffit Cancer center |
RECRUITING
|
| United States | New York Memorial Sloan Kettering Cancer Center |
RECRUITING
|
| Canada | Toronto Princess Margaret Cancer Centre University Health Network |
RECRUITING
|
| Germany | Berlin Charite Campus Benjamin Franklin |
RECRUITING
|
| Germany | Hannover Medizinische Hochschule Hannover |
RECRUITING
|
| Germany | Regensburg Universitaetsklinikum Regensburg |
RECRUITING
|
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