A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) (COPERNICUS)
Last Updated May 14, 2025
Want to learn how to participate in this trial?
61186372NSC2012
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 22 -
Sites
Sites -
Status
Recruiting
SUMMARY
The primary purpose of the study is to assess how well amivantamab subcutaneous (SC) administration in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC; that is one of the major types of lung cancer).
CONDITIONS
- Carcinoma, Non-Small-Cell Lung
ELIGIBILITY
Inclusion Criteria:
* Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC) that is not amenable to curative intent therapy
* Epidermal growth factor resistance-mutation (EGFRm) must be an Ex19del or Ex21 L858R substitution, as d
DETAILS
LOCATIONS
Locations in:
United States, Puerto Rico
| Country (2) | City or Province (95) | Status |
| United States | Los Alamitos Cancer and Blood Specialty Clinic |
RECRUITING
|
| United States | Santa Rosa Providence Medical Foundation |
RECRUITING
|
| United States | Hinsdale Hope and Healing Cancer Services |
RECRUITING
|
| United States | Wilson Regional Medical Oncology Center |
RECRUITING
|
| United States | El Paso Renovatio Clinical |
RECRUITING
|
| United States | Kingwood Community Clinical Trials |
RECRUITING
|
| United States | The Woodlands Renovatio Clinical |
RECRUITING
|
| United States | Fullerton Providence Medical Foundation |
RECRUITING
|
| United States | Glendale The Oncology Institute of Hope and Innovation |
RECRUITING
|
| United States | Glendale Oncology Physicians Network Healthcare |
RECRUITING
|
| United States | Glendale Los Angeles Cancer Network |
RECRUITING
|
| United States | Los Angeles USC Norris Comprehensive Cancer Center |
RECRUITING
|
| United States | Los Angeles Cedars Sinai Medical Center |
RECRUITING
|
| United States | Los Angeles Valkyrie Clinical Trials |
RECRUITING
|
| United States | Orange St. Joseph Hospital Center for Cancer Prevention and Treatment |
RECRUITING
|
| United States | Walnut Creek John Muir Health Clinical Research Center |
RECRUITING
|
| United States | New Haven Yale New Haven Hospital Yale Cancer Center |
RECRUITING
|
| United States | Orlando Orlando Health Cancer Institute |
RECRUITING
|
| United States | Atlanta Piedmont Healthcare |
RECRUITING
|
| United States | Atlanta Piedmont Cancer Institute |
RECRUITING
|
| United States | Atlanta Winship Cancer Institute Emory University |
RECRUITING
|
| United States | Noblesville Investigative Clinical Research of Indiana, LLC |
RECRUITING
|
| United States | Ames Accellacare of McFarland |
RECRUITING
|
| United States | Ypsilanti Trinity Health St Joseph Mercy Ann Arbor |
RECRUITING
|
| United States | Minneapolis University Of Minnesota |
RECRUITING
|
| United States | Jackson Jackson Oncology Associates |
RECRUITING
|
| United States | Saint Louis Washington University School Of Medicine |
RECRUITING
|
| United States | Flemington Hunterdon Hematology Oncology |
RECRUITING
|
| United States | New Brunswick Rutgers Cancer Institute of New Jersey |
RECRUITING
|
| United States | New York NYU Langone Health Laura and Isaac Perlmutter Cancer Center |
RECRUITING
|
| United States | New York Herbert Irving Comprehensive Cancer Center Columbia University Medical Center |
RECRUITING
|
| United States | Schenectady Ellis Hospital |
RECRUITING
|
| United States | Westbury Clinical Research Alliance Inc |
RECRUITING
|
| United States | Sioux Falls Avera Medical Group |
RECRUITING
|
| United States | Memphis Baptist Cancer Center |
RECRUITING
|
| United States | Dallas UT Southwestern Medical Center |
RECRUITING
|
| United States | Fort Worth JPS Health Network |
RECRUITING
|
| United States | Spokane Summit Cancer Centers |
RECRUITING
|
| Puerto Rico | San Juan Auxilio Mutuo Cancer Center |
RECRUITING
|
| United States | Huntsville Clearview Cancer Institute |
RECRUITING
|
| United States | Goodyear Cancer Treatment Center of America Phoenix |
RECRUITING
|
| United States | Corona City of Hope Corona |
RECRUITING
|
| United States | Duarte City of Hope |
RECRUITING
|
| United States | Glendale Glendale Adventist Medical Center |
RECRUITING
|
| United States | Greenbrae Marin Cancer Center |
RECRUITING
|
| United States | Huntington Beach City of Hope Seacliff |
RECRUITING
|
| United States | Irvine City of Hope Orange County Lennar Foundation Cancer Center |
RECRUITING
|
| United States | Lancaster City of Hope Antelope Valley |
RECRUITING
|
| United States | Long Beach City of Hope Long Beach Elm |
RECRUITING
|
| United States | Murrieta Valkyrie Clinical Trials |
RECRUITING
|
| United States | Oakland Kaiser Permanente Oakland Medical Center |
RECRUITING
|
| United States | Orange University of California Irvine |
RECRUITING
|
| United States | Roseville Kaiser Permanente Roseville Medical Center |
RECRUITING
|
| United States | San Francisco Kaiser Permanente San Francisco Medical Center |
RECRUITING
|
| United States | San Francisco UCSF Zuckerberg San Francisco General Hospital |
RECRUITING
|
| United States | Santa Clara Kaiser Permanente Santa Clara Medical Center |
RECRUITING
|
| United States | South Pasadena City of Hope South Pasadena |
RECRUITING
|
| United States | Upland City of Hope Upland |
RECRUITING
|
| United States | Vallejo Kaiser Permanente Northern California |
RECRUITING
|
| United States | Walnut Creek Kaiser Permanente Walnut Creek Medical Center |
RECRUITING
|
| United States | Washington MedStar Georgetown University Hospital |
RECRUITING
|
| United States | Washington Washington DC VA Medical Center |
RECRUITING
|
| United States | Fort Lauderdale The Oncology Institute of Hope and Innovation |
RECRUITING
|
| United States | Tampa Moffitt Cancer Center |
RECRUITING
|
| United States | Atlanta Grady Health System Correll Pavilion |
RECRUITING
|
| United States | Newnan City of Hope Cancer Center |
RECRUITING
|
| United States | Chicago University of Illinois at Chicago |
RECRUITING
|
| United States | Decatur Cancer Care Specialists of Central Illinois |
RECRUITING
|
| United States | Zion City of Hope Chicago |
RECRUITING
|
| United States | Fort Wayne Fort Wayne Medical Oncology and Hematology |
RECRUITING
|
| United States | Silver Spring Maryland Oncology Hematology P A |
RECRUITING
|
| United States | Boston Boston University Medical Center |
RECRUITING
|
| United States | Springfield Oncology Hematology Associates |
RECRUITING
|
| United States | Morristown Morristown Medical Center |
RECRUITING
|
| United States | Summit Overlook Medical Center |
RECRUITING
|
| United States | Teaneck Holy Name Medical Center |
RECRUITING
|
| United States | Albuquerque University of New Mexico |
RECRUITING
|
| United States | Bronx Montefiore Medical Center |
RECRUITING
|
| United States | East Syracuse Hematology-Oncology Associates of CNY |
RECRUITING
|
| United States | Mineola Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island |
RECRUITING
|
| United States | Shirley New York Cancer and Blood Specialists |
RECRUITING
|
| United States | Eugene Oncology Associates of Oregon PC Willamette Valley Cancer Institute |
RECRUITING
|
| United States | Portland Oregon Health And Science University |
RECRUITING
|
| United States | West Reading McGlinn Cancer Institute Reading Hospital |
RECRUITING
|
| United States | Chattanooga Tennessee Oncology |
RECRUITING
|
| United States | Knoxville University of Tennessee |
RECRUITING
|
| United States | Nashville SCRI Oncology Partners |
RECRUITING
|
| United States | Nashville Tennessee Oncology |
RECRUITING
|
| United States | Dallas Texas Oncology P A |
RECRUITING
|
| United States | Houston MD Anderson Cancer Center |
RECRUITING
|
| United States | Houston Oncology Consultants Texas |
RECRUITING
|
| United States | Tyler The University of Texas Health Science Center at Tyler |
RECRUITING
|
| United States | Salt Lake City Huntsman Cancer Institute |
RECRUITING
|
| United States | Olympia Vista Oncology |
RECRUITING
|
| United States | Vancouver Northwest Cancer Specialists - Vancouver |
RECRUITING
|
Geo Locations
33.80307, -118.07256
38.44047, -122.71443
41.80086, -87.93701
35.72127, -77.91554
31.75872, -106.48693
30.03355, -95.26104
30.15799, -95.48938
33.87029, -117.92534
34.14251, -118.25508
34.14251, -118.25508
34.14251, -118.25508
34.05223, -118.24368
34.05223, -118.24368
34.05223, -118.24368
33.78779, -117.85311
37.90631, -122.06496
41.30815, -72.92816
28.53834, -81.37924
33.749, -84.38798
33.749, -84.38798
33.749, -84.38798
40.04559, -86.0086
42.03471, -93.61994
42.24115, -83.61299
44.97997, -93.26384
32.29876, -90.18481
38.62727, -90.19789
40.51233, -74.85933
40.48622, -74.45182
40.71427, -74.00597
40.71427, -74.00597
42.81424, -73.93957
40.75566, -73.58763
43.54997, -96.70033
35.14953, -90.04898
32.78306, -96.80667
32.72541, -97.32085
47.65966, -117.42908
18.46633, -66.10572
34.7304, -86.58594
33.43532, -112.35821
33.87529, -117.56644
34.13945, -117.97729
34.14251, -118.25508
37.94854, -122.5247
33.6603, -117.99923
33.66946, -117.82311
34.69804, -118.13674
33.76696, -118.18923
33.55391, -117.21392
37.80437, -122.2708
33.78779, -117.85311
38.75212, -121.28801
37.77493, -122.41942
37.77493, -122.41942
37.35411, -121.95524
34.11612, -118.15035
34.09751, -117.64839
38.10409, -122.25664
37.90631, -122.06496
38.89511, -77.03637
38.89511, -77.03637
26.12231, -80.14338
27.94752, -82.45843
33.749, -84.38798
33.38067, -84.79966
41.85003, -87.65005
39.84031, -88.9548
42.44613, -87.83285
41.1306, -85.12886
38.99067, -77.02609
42.35843, -71.05977
37.21533, -93.29824
40.79677, -74.48154
40.71562, -74.36468
40.8976, -74.01597
35.08449, -106.65114
40.84985, -73.86641
43.06534, -76.07853
40.74927, -73.64068
40.80149, -72.8676
44.05207, -123.08675
45.52345, -122.67621
40.3337, -75.94743
35.04563, -85.30968
35.96064, -83.92074
36.16589, -86.78444
36.16589, -86.78444
32.78306, -96.80667
29.76328, -95.36327
29.76328, -95.36327
32.35126, -95.30106
40.76078, -111.89105
47.03787, -122.9007
45.63873, -122.66149
x
50
Indicates 50+ sites in this region: click to zoom in.
10
Indicates 10+ sites in this region: click to zoom in.
5
Indicates < 10 sites in this region: click to zoom in.
Corresponds to individual site.