A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG) (SunRISe-5)
Last Updated May 14, 2025
Want to learn how to participate in this trial?
17000139BLC3004
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 33 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to compare disease free survival (DFS) in participants with recurrence of papillary-only high-risk non-muscle-invasive bladder cancer (HR-NMIBC) within 1 year of last dose of Bacillus Calmette-Guérin (BCG) therapy and who refused or are unfit for Radical Cystectomy (RC), receiving TAR-200 versus investigator's choice of single agent intravesical chemotherapy.
CONDITIONS
- Non-Muscle Invasive Bladder Neoplasms
ELIGIBILITY
Inclusion Criteria:
* Histologically confirmed diagnosis by local pathology (within 90 days of documented informed consent) of recurrent, papillary-only high-risk non-muscle-invasive bladder cancer (HR-NMIBC) [defined as high-grade Ta or any T1, no carcinoma in situ (CIS)]
* Part
DETAILS
LOCATIONS
Locations in:
United States, Argentina, Brazil, China, Germany, Italy, Japan, South Korea, Poland, Spain, United Kingdom, Belgium, France, Romania
| Country (14) | City or Province (123) | Status |
| United States | Little Rock Arkansas Urology |
RECRUITING
|
| United States | Los Alamitos Genesis Research LLC |
RECRUITING
|
| United States | Orange University of California Irvine Medical Center |
RECRUITING
|
| United States | Torrance Genesis Research LLC |
RECRUITING
|
| United States | Lakewood Colorado Clinical Research |
RECRUITING
|
| United States | Riverview Florida Urology Partners |
RECRUITING
|
| United States | Chicago Ridge UroPartners |
RECRUITING
|
| United States | Carmel Urology of Indiana |
RECRUITING
|
| United States | Jeffersonville First Urology, PSC |
RECRUITING
|
| United States | Wichita Wichita Urology Group |
RECRUITING
|
| United States | Royal Oak Comprehensive Urology |
RECRUITING
|
| United States | Saint Louis Specialty Clinical Research of St Louis |
RECRUITING
|
| United States | Syracuse Associated Medical Professionals |
RECRUITING
|
| United States | Cincinnati The Urology Group |
RECRUITING
|
| United States | Gahanna Central Ohio Urology Group |
RECRUITING
|
| United States | Bala-Cynwyd Centers for Advanced Urology LLC d b a MidLantic Urology |
RECRUITING
|
| United States | Myrtle Beach Carolina Urologic Research Center |
RECRUITING
|
| United States | North Charleston Low Country Urology Clinics |
RECRUITING
|
| United States | Nashville Urology Associates |
RECRUITING
|
| United States | Austin Urology Austin |
RECRUITING
|
| United States | Dallas Urology Clinics of North Texas |
RECRUITING
|
| United States | Houston Houston Metro Urology |
RECRUITING
|
| United States | Spokane Spokane Urology |
RECRUITING
|
| Argentina | Buenos Aires Clinica Santa Isabel |
RECRUITING
|
| Argentina | Caba Investigaciones Clinico Moleculares (ICM) |
RECRUITING
|
| Argentina | Cordoba Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica |
RECRUITING
|
| Brazil | Barretos Fundacao Pio XII |
RECRUITING
|
| Brazil | Bauru NAIC Nair Antunes Instituto do Cancer |
RECRUITING
|
| Brazil | Porto Alegre Irmandade Santa Casa de Misericordia de Porto Alegre |
RECRUITING
|
| Brazil | Sao Paulo Real e Benemérita Associação Portuguesa de Beneficência |
RECRUITING
|
| Brazil | Sao Paulo Fundacao Antonio Prudente A C Camargo Cancer Center |
RECRUITING
|
| China | Beijing Peking University First Hospital |
RECRUITING
|
| China | Cheng Du Shi West China School of Medicine/West China Hospital, Sichuan University |
RECRUITING
|
| China | Chong Qing Chongqing Cancer Hospital |
RECRUITING
|
| China | Shen Yang Shi Shengjing Hospital Of China Medical University |
RECRUITING
|
| China | Tianjin Tianjin Medical University Cancer Institute and Hospital |
RECRUITING
|
| China | Tianjin The Second Hospital Of Tianjin Medical University |
RECRUITING
|
| China | Wenzhou The First Affiliated Hospital of Wenzhou Medical University |
RECRUITING
|
| China | Wuhan Tongji Medical College of Huazhong University Science Technology of Medicine Health Management |
RECRUITING
|
| China | XI An Shi Xi an Jiaotong University Hospital |
RECRUITING
|
| Germany | Halle (Saale) Universitaetsklinikum Halle Saale |
RECRUITING
|
| Germany | Köln Universitaetsklinikum Koeln |
RECRUITING
|
| Germany | Leverkusen Klinikum Leverkusen gGmbH |
RECRUITING
|
| Germany | Lubeck Universitatsklinikum Schleswig Holstein Campus Lubeck |
RECRUITING
|
| Germany | Mettmann Urologie Neandertal Praxis Mettmann |
RECRUITING
|
| Italy | Arezzo Ospedale San Donato |
RECRUITING
|
| Italy | Ravenna Ospedale S. Maria Delle Croci |
RECRUITING
|
| Italy | Roma Istituto Nazionale Tumori Regina Elena |
RECRUITING
|
| Italy | Rozzano Istituto Clinico Humanitas |
RECRUITING
|
| Italy | Torino PO Molinette Azienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino |
RECRUITING
|
| Japan | Hyogo Hyogo Prefectural Amagasaki General Medical Center |
RECRUITING
|
| Japan | Niigata Niigata Cancer Center Hospital |
RECRUITING
|
| Japan | Okayama National Hospital Organization Okayama Medical Center |
RECRUITING
|
| Japan | Sakura Toho University Sakura Medical Center |
RECRUITING
|
| Japan | Tokyo Toranomon Hospital |
RECRUITING
|
| Japan | Yokohama Yokohama City University Medical Center |
RECRUITING
|
| South Korea | Chungcheongbuk Do Chungbuk National University Hospital |
RECRUITING
|
| South Korea | Daegu Keimyung University Dongsan Hospital |
RECRUITING
|
| South Korea | Gyeonggi-do National Cancer Center |
RECRUITING
|
| South Korea | Jeollanam-do Chonnam National University Hwasun Hospital |
RECRUITING
|
| South Korea | Seoul Seoul National University Hospital |
RECRUITING
|
| South Korea | Seoul Samsung Medical Center |
RECRUITING
|
| South Korea | Yangsan-si Pusan National University Yangsan Hospital |
RECRUITING
|
| Poland | Torun MICS Centrum Medyczne Torun |
RECRUITING
|
| Poland | Wroclaw Dolnoslaskie Centrum Onkologii |
RECRUITING
|
| Spain | Madrid Hosp. Univ. 12 de Octubre |
RECRUITING
|
| Spain | Málaga Hosp Virgen de La Victoria |
RECRUITING
|
| Spain | Sabadell Hosp.Univ.Parc Tauli |
RECRUITING
|
| United Kingdom | London St Bartholomews Hospital |
RECRUITING
|
| United Kingdom | Salford Salford Royal Hospital |
RECRUITING
|
| United Kingdom | Southampton Southampton University Hospital |
RECRUITING
|
| United Kingdom | Stevenage Lister Hospital |
RECRUITING
|
| United States | Los Angeles USC Norris Comprehensive Cancer Center |
RECRUITING
|
| United States | San Francisco University of California San Francisco |
RECRUITING
|
| United States | Chicago Northwestern University |
RECRUITING
|
| United States | Charleston Ralph H. Johnson Veterans Affairs Medical Center |
RECRUITING
|
| United States | Nashville Vanderbilt University Medical Center |
RECRUITING
|
| United States | Dallas University of Texas Southwestern Medical Center |
RECRUITING
|
| Argentina | Mar del Plata Hospital Privado de la Comunidad |
COMPLETED
|
| Brazil | Campinas Hospital das Clinicas da Universidade Estadual de Campinas UNICAMP |
RECRUITING
|
| Brazil | Curitiba Liga Paranaense de Combate ao Cancer |
RECRUITING
|
| Brazil | Salvador Hospital da Bahia |
RECRUITING
|
| Brazil | São Paulo Sociedade Beneficente de Senhoras Hospital Sirio Libanes |
RECRUITING
|
| Italy | Macerata Ospedale Provinciale di Macerata |
RECRUITING
|
| Italy | Milano San Raffaele Hospital |
RECRUITING
|
| Italy | Milano Istituto Dei Tumori Di Milano |
RECRUITING
|
| Italy | Roma Universita Campus Bio-Medico di Roma |
RECRUITING
|
| Japan | Hakodate Hakodate Goryoukaku Hospital |
RECRUITING
|
| Poland | Bialystok Uniwersytecki Szpital Kliniczny w Bialymstoku |
RECRUITING
|
| Poland | Krakow Szpital Uniwersytecki w Krakowie |
RECRUITING
|
| Poland | Lublin Uniwersytecki Szpital Kliniczny nr 4 |
RECRUITING
|
| Spain | Badalona Hosp. Univ. Germans Trias I Pujol |
RECRUITING
|
| Spain | Barcelona Fund. Puigvert |
RECRUITING
|
| Spain | Madrid Hosp. Gral. Univ. Gregorio Maranon |
RECRUITING
|
| Spain | Santander Hosp. Univ. Marques de Valdecilla |
RECRUITING
|
| Spain | Sevilla Hosp. Virgen Del Rocio |
RECRUITING
|
| Spain | Valencia Hosp. Clinico Univ. de Valencia |
RECRUITING
|
| Argentina | Cordoba Centro Urologico Profesor Bengio |
RECRUITING
|
| Belgium | Brugge AZ Sint-Jan |
ACTIVE_NOT_RECRUITING
|
| Belgium | Bruxelles Cliniques Universitaires Saint Luc |
ACTIVE_NOT_RECRUITING
|
| Belgium | Genk Ziekenhuis Oost-Limburg |
ACTIVE_NOT_RECRUITING
|
| Belgium | Gent Algemeen ziekenhuis Maria Middelares |
ACTIVE_NOT_RECRUITING
|
| Belgium | Roeselare Algemeen Ziekenhuis Delta |
ACTIVE_NOT_RECRUITING
|
| China | Guang Zhou Shi Sun Yat Sen University Cancer Center |
RECRUITING
|
| France | Lille Hopital Claude Huriez |
ACTIVE_NOT_RECRUITING
|
| France | Limoges Polyclinique de Limoges - Francois Chenieux |
COMPLETED
|
| France | Marseille Institut Paoli Calmettes |
ACTIVE_NOT_RECRUITING
|
| France | Paris APHP - Hopital Bichat - Claude Bernard |
COMPLETED
|
| France | Quint-Fonsegrives Clinique de la Croix du Sud |
ACTIVE_NOT_RECRUITING
|
| France | Rennes Chu Rennes Hopital Pontchaillou |
ACTIVE_NOT_RECRUITING
|
| France | Suresnes Hopital Foch |
ACTIVE_NOT_RECRUITING
|
| Germany | Munchen Klinikum der Universitaet Muenchen |
RECRUITING
|
| Japan | Funabashi shi Funabashi Munitiple Medical Center |
RECRUITING
|
| South Korea | Seoul The Catholic University of Korea Seoul St Mary s Hospital |
COMPLETED
|
| Poland | Bydgoszcz IN VIVO Sp. z o.o |
ACTIVE_NOT_RECRUITING
|
| Poland | Przemysl Wojewodzki Szpital im Sw Ojca Pio w Przemyslu |
RECRUITING
|
| Poland | Tarnow Szpital Wojewodzki im Sw Lukasza SP ZOZ |
ACTIVE_NOT_RECRUITING
|
| Poland | Wieliszew Mazowiecki Szpital Onkologiczny |
ACTIVE_NOT_RECRUITING
|
| Romania | Brasov Centrul Medical Unirea SRL |
ACTIVE_NOT_RECRUITING
|
| Romania | Bucuresti Ponderas Academic Hospital |
COMPLETED
|
| Romania | Cluj-Napoca Institutul Oncologic Ion Chiricuta |
ACTIVE_NOT_RECRUITING
|
| Romania | Cluj-Napoca Regina Maria |
COMPLETED
|
| Romania | Timisoara Spitalul Clinic Judetean de Urgenta Pius Brinzeu |
COMPLETED
|
Geo Locations
34.74648, -92.28959
33.80307, -118.07256
33.78779, -117.85311
33.83585, -118.34063
39.70471, -105.08137
27.86614, -82.32648
41.70142, -87.77922
39.97837, -86.11804
38.27757, -85.73718
37.69224, -97.33754
42.48948, -83.14465
38.62727, -90.19789
43.04812, -76.14742
39.12713, -84.51435
40.01923, -82.87934
40.00761, -75.23407
33.68906, -78.88669
32.85462, -79.97481
36.16589, -86.78444
30.26715, -97.74306
32.78306, -96.80667
29.76328, -95.36327
47.65966, -117.42908
-34.61315, -58.37723
-34.61315, -58.37723
-31.4135, -64.18105
-20.55722, -48.56778
-22.31472, -49.06056
-30.03306, -51.23
-23.5475, -46.63611
-23.5475, -46.63611
39.9075, 116.39723
30.5970699, 104.05106
29.6433899, 106.45187
41.7822799, 123.42179
39.14222, 117.17667
39.14222, 117.17667
27.99942, 120.66682
30.58333, 114.26667
34.2075699, 108.94631
51.48159, 11.97948
50.93333, 6.95
51.0303, 6.98432
53.86893, 10.68729
51.2504, 6.97536
43.46276, 11.88068
44.41344, 12.20121
41.89193, 12.51133
45.38193, 9.1559
45.07049, 7.68682
34.7300449, 135.4133985
37.88637, 139.00589
34.65, 133.93333
35.71667, 140.23333
35.6895, 139.69171
35.43333, 139.65
36.6266068, 127.4570629
35.87028, 128.59111
37.58944, 126.76917
35.056264, 127.0025403
37.566, 126.9784
37.566, 126.9784
35.3251513, 129.0068369
53.01375, 18.59814
51.1, 17.03333
40.4165, -3.70256
36.72016, -4.42034
41.54329, 2.10942
51.50853, -0.12574
53.48771, -2.29042
50.90395, -1.40428
51.90224, -0.20256
34.05223, -118.24368
37.77493, -122.41942
41.85003, -87.65005
32.77657, -79.93092
36.16589, -86.78444
32.78306, -96.80667
-38.00228, -57.55754
-22.90556, -47.06083
-25.42778, -49.27306
-12.97111, -38.51083
-23.5475, -46.63611
43.29789, 13.45293
45.46427, 9.18951
45.46427, 9.18951
41.89193, 12.51133
41.77583, 140.73667
53.13333, 23.16433
50.06143, 19.93658
51.25, 22.56667
41.45004, 2.24741
41.38879, 2.15899
40.4165, -3.70256
43.46472, -3.80444
37.38283, -5.97317
39.46975, -0.37739
-31.4135, -64.18105
51.20892, 3.22424
50.85045, 4.34878
50.965, 5.50082
51.05, 3.71667
50.94653, 3.12269
23.1323999, 113.288
50.63297, 3.05858
45.83153, 1.25781
43.29551, 5.38958
48.85341, 2.3488
43.5852, 1.5272
48.11198, -1.67429
48.87143, 2.22929
48.13743, 11.57549
35.70129, 139.98648
37.566, 126.9784
53.1235, 18.00762
49.78498, 22.76728
50.01381, 20.98698
52.4513, 20.96827
45.64861, 25.60613
44.42802, 26.09665
46.76667, 23.6
46.76667, 23.6
45.75372, 21.22571
x
50
Indicates 50+ sites in this region: click to zoom in.
10
Indicates 10+ sites in this region: click to zoom in.
5
Indicates < 10 sites in this region: click to zoom in.
Corresponds to individual site.