A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With B

A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer (MoonRISe-1)

Last Updated May 14, 2025

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42756493BLC3004

OVERVIEW

Sexes Eligible for Study
all
Age
18+ years
Phase
phase 3

3
Sites
190 Sites
Status

Recruiting

SUMMARY

The main purpose of this study is to compare the disease-free survival between participants receiving treatment with TAR-210 versus investigator's choice of intravesical chemotherapy for treatment of intermediate-risk NMIBC.

CONDITIONS

Non-Muscle Invasive Bladder Cancer

ELIGIBILITY

Inclusion Criteria:

* Have a histologically confirmed diagnosis (within 90 days of randomization) of IR-NMIBC with at least one of the following criteria fulfilled: a. Ta low grade (LG)/ Grade 1 (G1): primary or recurrent, b. Ta LG/G2: primary or recurrent and c. Greater than or equal to (>=) 1 of the following risk factors: i. Multiple Ta LG tumors, ii. Solitary LG tumor >= 3 cm, iii. Early recurrence (less than [<] 1 year), iv. Frequent recurrence (greater than [>] 1 per year), v. Recurrence after prior adjuvant intravesical treatment (single perioperative dose of chemotherapy does not fulfill this risk factor)
* Have a susceptible fibroblast growth factor receptor (FGFR) mutation or fusion either by urine testing or tumor tissue testing (from TURBT tissue), as determined by central or local testing
* Participants must be willing to undergo all study procedures (e.g., multiple cystoscopies from Screening through the end of study and TURBT for assessment of recurrence/progression) and receive the assigned treatment, including intravesical chemotherapy if randomized into that arm.
* Visible papillary disease must be fully resected prior to randomization and absence of disease must be documented at Screening cystoscopy
* Can have a prior or concurrent second malignancy (other than the disease under study) which natural history or treatment is unlikely to interfere with any study endpoints of safety or the efficacy of the study treatment
* Have an Eastern Cooperative Oncology Group performance status of 0 to 2

Exclusion Criteria:

* Known allergies, hypersensitivity, or intolerance to any study component or its excipients, including: a. Erdafitinib excipients; b.TAR-210 drug delivery system constituent materials ; c. urinary placement catheter materials; d. MMC or chemically related drugs; e. Gemcitabine or chemically related drugs
* Presence of any bladder or urethral anatomic feature (that is, urethral stricture) that, in the opinion of the investigator, may prevent the safe insertion, indwelling use, removal of TAR-210 or passage of a urethral catheter for intravesical chemotherapy
* Polyuria with recorded 24-hour urine volumes > 4000 milliliters (mL)
* Current indwelling urinary catheters, however, intermittent catheterization is acceptable
* Had major surgery or had significant traumatic injury and/or not fully recovered within 4 weeks before first dose (TURBT is not considered major surgery)

Inclusion Criteria:

More...

DETAILS

LOCATIONS

Locations in:

United States, Argentina, Hong Kong, Israel, Japan, South Korea, Poland, Spain, United Kingdom, Austria, Belgium, Brazil, China, Czechia, Denmark, France, Germany, Ireland, Italy, Türkiye

Country (20)	City or Province (190)	Status
United States	Little Rock Arkansas Urology	RECRUITING
United States	Los Alamitos Genesis Research LLC	RECRUITING
United States	San Diego Genesis Research	RECRUITING
United States	Sherman Oaks Genesis Research LLC	RECRUITING
United States	Lakewood Colorado Clinical Research	RECRUITING
United States	Jeffersonville First Urology	RECRUITING
United States	Royal Oak Comprehensive Urology	RECRUITING
United States	Saint Louis Specialty Clinical Research of St Louis	RECRUITING
United States	New Brunswick Cancer Institute Of New Jersey	RECRUITING
United States	New York Integrated Medical Professionals	RECRUITING
United States	Syracuse Associated Medical Professionals of Ny	RECRUITING
United States	Raleigh Associated Urologists of North Carolina	RECRUITING
United States	Bala-Cynwyd MidLantic Urology	RECRUITING
United States	Lancaster Keystone Urology Specialists	RECRUITING
United States	Myrtle Beach Carolina Urologic Research Center	RECRUITING
United States	Germantown The Conrad Pearson Clinic	RECRUITING
United States	Nashville Urology Associates	RECRUITING
United States	Austin Urology Austin	RECRUITING
United States	Dallas Urology Clinics of North Texas	RECRUITING
United States	Houston Houston Metro Urology	RECRUITING
United States	Spokane Spokane Urology	RECRUITING
Argentina	Caba Investigaciones Clinico Moleculares (ICM)	RECRUITING
Argentina	Ciudad Autonoma de Buenos Aires Hospital Sirio Libanes	RECRUITING
Hong Kong	Hong Kong Prince Of Wales Hospital	RECRUITING
Hong Kong	Hong Kong Queen Mary Hospital	RECRUITING
Israel	Haifa Rambam Health Care Campus	RECRUITING
Israel	Jerusalem Hadassah University Hospita Ein Kerem	RECRUITING
Israel	Safed Ziv Medical Center	RECRUITING
Israel	Tel-Aviv Sourasky Medical Center	RECRUITING
Japan	Kawasaki Shi St Marianna University Hospital	RECRUITING
Japan	Wakayama JRC Wakayama Medical Center	RECRUITING
Japan	Yokohama Yokohama City University Medical Center	RECRUITING
Japan	Yokosuka Yokosuka Kyosai Hospital	RECRUITING
South Korea	Jeollanam-do Chonnam National University Hwasun Hospital	RECRUITING
South Korea	Seoul Samsung Medical Center	RECRUITING
Poland	Tarnow Szpital Wojewodzki Im Sw Lukasza Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Tarnowie	RECRUITING
Spain	Madrid Hosp. Univ. 12 de Octubre	RECRUITING
United Kingdom	London St Bartholomews Hospital	RECRUITING
United Kingdom	London Charing Cross Hospital	RECRUITING
United Kingdom	Sutton Royal Marsden Hospital	RECRUITING
United States	Los Angeles USC Norris Comprehensive Cancer Center	RECRUITING
United States	Orange University of California Irvine Medical Center	RECRUITING
United States	Aurora University of Colorado Cancer Center Anschultz Cancer Pavilion	RECRUITING
United States	Tampa Moffitt Cancer Center	RECRUITING
United States	Chicago Northwestern University	RECRUITING
United States	Wichita Wichita Urology Group	RECRUITING
United States	New Orleans Ochsner Health System	RECRUITING
United States	Detroit Karmanos Cancer Institute	RECRUITING
United States	Saint Louis Mercy Research	RECRUITING
United States	Omaha The Urology Center, PC	RECRUITING
United States	Syracuse SUNY Upstate Med Univ	RECRUITING
United States	Charlotte Levine Cancer Institute	RECRUITING
United States	Knoxville University of Tennessee Medical Center	RECRUITING
Argentina	Cordoba Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica	RECRUITING
Argentina	Mar del Plata Hospital Privado de la Comunidad	RECRUITING
Argentina	Rosario Sanatorio de la Mujer	RECRUITING
Austria	Graz Medizinische Universitaet Graz	RECRUITING
Austria	Linz Ordensklinikum Linz GmbH Elisabethinen	RECRUITING
Austria	Salzburg Universitaetsklinikum Salzburg Landeskrankenhaus	RECRUITING
Austria	Wien Medical University Vienna MUV	RECRUITING
Belgium	Aalst Onze -Lieve-Vrouwziekenhuis	RECRUITING
Belgium	Brugge AZ Sint-Jan	RECRUITING
Belgium	Edegem UZ Antwerpen	RECRUITING
Belgium	Gent AZ Maria Middelares	RECRUITING
Belgium	Leuven Universitair Ziekenhuis Gasthuisberg	RECRUITING
Belgium	Sint Niklaas Vitaz	RECRUITING
Belgium	Yvoir CHU UCL Namur - Site Godinne	RECRUITING
Brazil	Barretos Fundacao Pio XII	RECRUITING
Brazil	Campinas Universidade Estadual De Campinas	RECRUITING
Brazil	Natal Liga Norte Riograndense Contra O Cancer	RECRUITING
Brazil	Porto Alegre Associacao Hospitalar Moinhos de Vento	RECRUITING
Brazil	Porto Alegre Irmandade da Santa Casa de Misericordia de Porto Alegre	RECRUITING
Brazil	Salvador HBA SA Assitencia Medica e Hospitalar	RECRUITING
Brazil	Santo Andre Fundacao do ABC Centro Universitario FMABC	RECRUITING
Brazil	Sao Paulo Irmandade Da Santa Casa De Misericordia De Sao Paulo	RECRUITING
Brazil	Sao Paulo Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo	RECRUITING
Brazil	Sao Paulo Real e Benemérita Associação Portuguesa de Beneficência	RECRUITING
Brazil	Sao Paulo Fundacao Antonio Prudente A C Camargo Cancer Center	RECRUITING
China	Beijing Beijing Friendship Hospital Capital Medical University	RECRUITING
China	Beijing Peking University Third Hospital	RECRUITING
China	Changsha Hunan Cancer hospital	RECRUITING
China	Cheng Du Shi The Third People's Hospital of Chengdu	RECRUITING
China	Cheng Du Shi West China School of Medicine/West China Hospital, Sichuan University	RECRUITING
China	Chong Qing Chongqing Cancer Hospital	RECRUITING
China	Fu Zhou Shi Fujian Medical University Union Hospital	RECRUITING
China	Nan Jing Shi Nanjing Drum Tower Hospital	RECRUITING
China	Nan Jing Shi Zhongda Hospital Southeast University	RECRUITING
China	Shanghai Huadong Hospital Affiliated to Fudan University	RECRUITING
China	Tianjin The Second Hospital Of Tianjin Medical University	RECRUITING
China	Urumqi Cancer Hospital of Xinjiang Medical University	RECRUITING
China	Wenzhou The First Affiliated Hospital of Wenzhou Medical University	RECRUITING
China	Wu Han Shi Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology	RECRUITING
China	XI An Shi The First Affiliated Hospital of Xian Jiaotong University	RECRUITING
China	Xuzhou The Affiliated Hospital of Xuzhou Medical University	RECRUITING
Czechia	Hradec Kralove Fakultni nemocnice Hradec Kralove	RECRUITING
Czechia	Olomouc Fakultni nemocnice Olomouc	RECRUITING
Czechia	Praha 2 Vseobecna fakultni nemocnice v Praze	RECRUITING
Czechia	Praha 4 Fakultni Thomayerova nemocnice	RECRUITING
Czechia	Praha Fakultni nemocnice v Motole	RECRUITING
Denmark	Aarhus Aarhus University Hospital	RECRUITING
Denmark	Herlev Herlev Hospital	RECRUITING
Denmark	Kobenhavn Rigshospitalet	RECRUITING
Denmark	Odense Odense Universitetshospital	RECRUITING
Denmark	Roskilde Zealand University Hospital	RECRUITING
France	Lille Hospital Center University De Lille	RECRUITING
France	Limoges Polyclinique de Limoges - Francois Chenieux	RECRUITING
France	Lyon Hôpital Edouard Herriot	RECRUITING
France	Marseille Institut Paoli Calmettes	RECRUITING
France	Paris Hopital Saint Louis	RECRUITING
France	Paris CHU Pitie Salpetriere	RECRUITING
France	Paris APHP - Hopital Bichat - Claude Bernard	RECRUITING
France	Quint-Fonsegrives Clinique de la Croix du Sud	RECRUITING
France	Rennes Chu Rennes Hopital Pontchaillou	RECRUITING
France	Toulouse CHU Rangueil	RECRUITING
France	Villejuif Institut Gustave Roussy	RECRUITING
Germany	Berlin Charite - Universitaetsmedizin Berlin (CCM)	RECRUITING
Germany	Braunschweig Stadtisches Klinikum Braunschweig gGmbH-Klinik fur Urologie und Uroonkologie	RECRUITING
Germany	Dresden Urologische Gemeinschaftspraxis	RECRUITING
Germany	Frankfurt am Main Universitaetsklinikum Frankfurt	RECRUITING
Germany	Hamburg Urologikum Hamburg MVZ - Germany	RECRUITING
Germany	Herne Marien hospital Herne	RECRUITING
Germany	Jena Universitatsklinikum Jena	RECRUITING
Germany	Koeln Studienzentrum Bayenthal	RECRUITING
Germany	Munchen Klinikum rechts der Isar an der Technischen Universitat Munchen	RECRUITING
Germany	Straubing Klinikum St. Elisabeth Straubing GmbH	RECRUITING
Germany	Stuttgart Katharinenhospital Innere Medizin	RECRUITING
Ireland	Cork Cork University Hospital	RECRUITING
Ireland	Dublin Mater Misericordiae University Hospital	RECRUITING
Ireland	Dublin Mater Private Hospital	RECRUITING
Ireland	Dublin Adelaide and Meath Hospital	RECRUITING
Israel	Ramat Gan Sheba Medical Center	RECRUITING
Italy	Arezzo Ospedale S. Donato Arezzo, USL 8 - U.O. Oncologia Medica	RECRUITING
Italy	Bergamo Cliniche Humanitas Gavazzeni	RECRUITING
Italy	Brescia ASST Spedali Civili Brescia	RECRUITING
Italy	Milano Ospedale San Raffaele	RECRUITING
Italy	Milano Istituto Dei Tumori Di Milano	RECRUITING
Italy	Roma Universita Campus Bio-Medico di Roma	RECRUITING
Italy	Roma Istituto Nazionale Tumori Regina Elena	RECRUITING
Italy	Rozzano Istituto Clinico Humanitas	RECRUITING
Italy	Torino A.O.Citta della Salute e della Scienza di Torino	RECRUITING
Japan	Amagasaki shi Hyogo Prefectural Amagasaki General Medical Center	RECRUITING
Japan	Kobe City Kobe City Medical Center General Hospital	RECRUITING
Japan	Kumamoto City National Hospital Organization Kumamoto Medical Center	RECRUITING
Japan	Osaka Osaka International Cancer Institute	RECRUITING
Japan	Ota Gunma Prefectural Cancer Center	RECRUITING
Japan	Saitama Saitama Medical Center	RECRUITING
Japan	Yokohama Yokohama Municipal Citizen's Hospital	RECRUITING
South Korea	Chungcheongbuk Do Chungbuk National University Hospital	RECRUITING
South Korea	Gyeonggi-do National Cancer Center	RECRUITING
South Korea	Seoul The Catholic University of Korea Seoul St Marys Hospital	RECRUITING
South Korea	Seoul Seoul National University Hospital	RECRUITING
Poland	Bialystok Uniwersytecki Szpital Kliniczny w Bialymstoku	RECRUITING
Poland	Bydgoszcz IN VIVO Sp. z o.o	RECRUITING
Poland	Bydgoszcz Centrum Onkologii im Prof F Lukaszczyka w Bydgoszczy	RECRUITING
Poland	Lublin Uniwersytecki Szpital Kliniczny nr 4	RECRUITING
Poland	Przemysl Wojewodzki Szpital im Sw Ojca Pio w Przemyslu	RECRUITING
Poland	Torun Medicover Integrated Clinical Services Sp z o o	RECRUITING
Poland	Wieliszew Mazowiecki Szpital Onkologiczny Sp z o o	RECRUITING
Poland	Wroclaw 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu	RECRUITING
Poland	Wroclaw Dolnoslaskie Centrum Onkologii Pulmonologii i Hematologii	RECRUITING
Spain	A Coruna Hosp Univ A Coruna	RECRUITING
Spain	Alzira Hosp. Univ. de La Ribera	RECRUITING
Spain	Barcelona Fund. Puigvert	RECRUITING
Spain	Barcelona Hosp Univ Vall D Hebron	RECRUITING
Spain	Barcelona Hosp Clinic de Barcelona	RECRUITING
Spain	Cadiz Hosp. Puerta Del Mar	RECRUITING
Spain	Castellon Hosp. Gral. Univ. de Castellon	RECRUITING
Spain	Jerez De La Frontera Hosp. de Jerez de La Frontera	RECRUITING
Spain	Madrid Hosp. Gral. Univ. Gregorio Maranon	RECRUITING
Spain	Madrid Clinica Univ. de Navarra	RECRUITING
Spain	Malaga Hosp Virgen de La Victoria	RECRUITING
Spain	Oviedo Hosp. Univ. Central de Asturias	RECRUITING
Spain	Sabadell Hosp.Univ.Parc Tauli	RECRUITING
Spain	Sevilla Hosp. Virgen Del Rocio	RECRUITING
Spain	Valencia Hosp. Clinico Univ. de Valencia	RECRUITING
Türkiye	Adana Adana Baskent Practice and Research Hospital	RECRUITING
Türkiye	Ankara Ankara University Medical Faculty	RECRUITING
Türkiye	Ankara Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital	RECRUITING
Türkiye	Istanbul Istanbul University Cerrahpasa Medical Faculty	RECRUITING
Türkiye	Istanbul T C Saglik Bakanlıgi Goztepe Prof Dr Suleyman Yalcın Sehir Hastanesi	RECRUITING
Türkiye	Istanbul Kartal Dr Lutfi Kirdar sehir Hastanesi	RECRUITING
Türkiye	Izmir Dokuz Eylul University Medical Faculty	RECRUITING
United Kingdom	Bristol Southmead Hospital	RECRUITING
United Kingdom	Newcastle Upon Tyne Newcastle Freeman Hospital	RECRUITING
United Kingdom	Sheffield Sheffield Teaching Hospitals NHS Foundation Trust	RECRUITING
United Kingdom	Southampton Southampton General Hospital	RECRUITING
United States	Hanover Chesapeake Urology Research Associates	COMPLETED
Argentina	Cordoba Centro Urologico Profesor Bengio	RECRUITING
Austria	Innsbruck Medizinische Universitat Innsbruck	RECRUITING
China	Guang Zhou Shi Sun Yat Sen University Cancer Center	RECRUITING

Geo Locations

34.74648, -92.28959

33.80307, -118.07256

32.71533, -117.15726

34.15112, -118.44925

39.70471, -105.08137

38.27757, -85.73718

42.48948, -83.14465

38.62727, -90.19789

40.48622, -74.45182

40.71427, -74.00597

43.04812, -76.14742

35.7721, -78.63861

40.00761, -75.23407

40.03788, -76.30551

33.68906, -78.88669

35.08676, -89.81009

36.16589, -86.78444

30.26715, -97.74306

32.78306, -96.80667

29.76328, -95.36327

47.65966, -117.42908

-34.61315, -58.37723

22.27832, 114.17469

32.81841, 34.9885

31.76904, 35.21633

32.96465, 35.496

32.08088, 34.78057

35.52056, 139.71722

34.23333, 135.16667

35.43333, 139.65

35.28361, 139.66722

35.056264, 127.0025403

37.566, 126.9784

50.01381, 20.98698

40.4165, -3.70256

51.50853, -0.12574

51.35, -0.2

34.05223, -118.24368

33.78779, -117.85311

39.72943, -104.83192

27.94752, -82.45843

41.85003, -87.65005

37.69224, -97.33754

29.95465, -90.07507

42.33143, -83.04575

38.62727, -90.19789

41.25626, -95.94043

43.04812, -76.14742

35.22709, -80.84313

35.96064, -83.92074

-31.4135, -64.18105

-38.00228, -57.55754

-32.94682, -60.63932

47.06667, 15.45

48.30639, 14.28611

47.79941, 13.04399

48.20849, 16.37208

50.93604, 4.0355

51.20892, 3.22424

51.15662, 4.44504

51.05, 3.71667

50.87959, 4.70093

51.16509, 4.1437

50.3279, 4.88059

-20.55722, -48.56778

-22.90556, -47.06083

-5.795, -35.20944

-30.03306, -51.23

-12.97111, -38.51083

-23.66389, -46.53833

-23.5475, -46.63611

39.9075, 116.39723

28.19874, 112.97087

30.6715699, 104.06623

30.5970699, 104.05106

29.6433899, 106.45187

26.0855999, 119.307

32.0504399, 118.77799

32.0722999, 118.7799999

31.22222, 121.45806

39.14222, 117.17667

43.80096, 87.60046

27.99942, 120.66682

30.5898799, 114.25096

34.2075699, 108.94631

34.18045, 117.15707

50.20923, 15.83277

49.59552, 17.25175

50.08804, 14.42076

56.15674, 10.21076

55.72366, 12.43998

55.67594, 12.56553

55.39594, 10.38831

55.64152, 12.08035

50.63297, 3.05858

45.83153, 1.25781

45.74848, 4.84669

43.29551, 5.38958

48.85341, 2.3488

43.5852, 1.5272

48.11198, -1.67429

43.60426, 1.44367

48.7939, 2.35992

52.52437, 13.41053

52.26594, 10.52673

51.05089, 13.73832

50.11552, 8.68417

53.57532, 10.01534

51.5388, 7.22572

50.92878, 11.5899

50.93333, 6.95

48.13743, 11.57549

48.88126, 12.57385

48.78232, 9.17702

51.89797, -8.47061

53.33306, -6.24889

32.08227, 34.81065

43.46276, 11.88068

45.69601, 9.66721

45.53558, 10.21472

45.46427, 9.18951

41.89193, 12.51133

45.38193, 9.1559

45.07049, 7.68682

34.71667, 135.41667

34.6913, 135.183

32.80589, 130.69182

34.69374, 135.50218

36.3, 139.36667

35.90807, 139.65657

35.43333, 139.65

36.6266068, 127.4570629

37.58944, 126.76917

37.566, 126.9784

53.13333, 23.16433

53.1235, 18.00762

51.25, 22.56667

49.78498, 22.76728

53.01375, 18.59814

52.4513, 20.96827

51.1, 17.03333

43.37135, -8.396

39.15, -0.43333

41.38879, 2.15899

36.52672, -6.2891

39.9855905, -0.0496388

36.68645, -6.13606

40.4165, -3.70256

36.72016, -4.42034

43.36029, -5.84476

41.54329, 2.10942

37.38283, -5.97317

39.46975, -0.37739

37.00167, 35.32889

39.91987, 32.85427

41.01384, 28.94966

38.41273, 27.13838

51.45523, -2.59665

54.97328, -1.61396

53.38297, -1.4659

50.90395, -1.40428

39.19289, -76.72414

-31.4135, -64.18105

47.26266, 11.39454

23.1323999, 113.288

Indicates 50+ sites in this region: click to zoom in.

Indicates 10+ sites in this region: click to zoom in.

Indicates < 10 sites in this region: click to zoom in.

Corresponds to individual site.

OVERVIEW

Sexes Eligible for Study

Age

Phase

Sites

Status

SUMMARY

CONDITIONS

ELIGIBILITY

DETAILS

LOCATIONS

34.74648, -92.28959

33.80307, -118.07256

32.71533, -117.15726

34.15112, -118.44925

39.70471, -105.08137

38.27757, -85.73718

42.48948, -83.14465

38.62727, -90.19789

40.48622, -74.45182

40.71427, -74.00597

43.04812, -76.14742

35.7721, -78.63861

40.00761, -75.23407

40.03788, -76.30551

33.68906, -78.88669

35.08676, -89.81009

36.16589, -86.78444

30.26715, -97.74306

32.78306, -96.80667

29.76328, -95.36327

47.65966, -117.42908

-34.61315, -58.37723

-34.61315, -58.37723

22.27832, 114.17469

22.27832, 114.17469

32.81841, 34.9885

31.76904, 35.21633

32.96465, 35.496

32.08088, 34.78057

35.52056, 139.71722

34.23333, 135.16667

35.43333, 139.65

35.28361, 139.66722

35.056264, 127.0025403

37.566, 126.9784

50.01381, 20.98698

40.4165, -3.70256

51.50853, -0.12574

51.50853, -0.12574

51.35, -0.2

34.05223, -118.24368

33.78779, -117.85311

39.72943, -104.83192

27.94752, -82.45843

41.85003, -87.65005

37.69224, -97.33754

29.95465, -90.07507

42.33143, -83.04575

38.62727, -90.19789

41.25626, -95.94043

43.04812, -76.14742

35.22709, -80.84313

35.96064, -83.92074

-31.4135, -64.18105

-38.00228, -57.55754

-32.94682, -60.63932

47.06667, 15.45

48.30639, 14.28611

47.79941, 13.04399

48.20849, 16.37208

50.93604, 4.0355

51.20892, 3.22424

51.15662, 4.44504

51.05, 3.71667

50.87959, 4.70093

51.16509, 4.1437

50.3279, 4.88059

-20.55722, -48.56778

-22.90556, -47.06083