A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer (MoonRISe-3)
Last Updated July 31, 2025
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42756493BLC3005
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 3 -
Sites
Sites -
Status
Not yet recruiting
SUMMARY
The main purpose of this study is to compare the disease-free survival (the length of time after randomization that a participant survives without any signs or symptoms of the cancer returning, or progressing) between Bacillus Calmette-Guérin (BCG) treated participants receiving treatment with TAR-210 versus investigator's choice of intravesical chemotherapy for treatment of high-risk non-muscle-invasive bladder cancer (HR-NMIBC).
CONDITIONS
- Non-Muscle Invasive Bladder Neoplasms
ELIGIBILITY
Inclusion criteria:
* Histologically confirmed diagnosis by local pathology of papillary-only HR-NMIBC (defined as high-grade Ta or any T1, no CIS). Mixed histology tumors are allowed if urothelial differentiation is predominant. However, neuroendocrine, and small cell variants will
DETAILS
LOCATIONS
Country (1) | City or Province (11) | Status |
United States | Mesa Arizona Arthritis & Rheumatology Research, PLLC |
|
United States | Canyon Country Clearview Medical Research, LLC |
|
United States | La Palma Arthritis & Osteoporosis Medical Center - La Palma |
|
United States | Los Alamitos Valerius Medical Group & Research Center |
|
United States | Palm Springs Respire Research, LLC |
|
United States | DeBary Omega Research Consultants |
|
United States | Gainesville University of Florida Health Jacksonville - Rheumatology |
|
United States | Miami Reliant Medical Research |
|
United States | Plantation Integral Rheumatology & Immunology Specialists |
|
United States | El Paso Davita Clinical Research |
|
United States | Houston Next Innovative Clinical Research |
|
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