A Study of Combination Therapy With Amivantamab and Docetaxel in Participants With Metastatic Non-small Cell Lung Cancer (swalloWTail)
Last Updated April 25, 2025
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61186372PANSC2003
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 11 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to identify the recommended Phase 2 (combination) dose (RP2CD) of the amivantamab and docetaxel combination therapy in participants with metastatic non-small cell lung cancer (NSCLC) in Phase 1 (combination dose selection); and to evaluate the antitumor effect of the combination at the selected RP2CD in participants with NSCLC without oncogenic driver mutations with disease progression on platinum-based chemotherapy and immune checkpoint inhibitor, in the Phase 2 (expansion).
CONDITIONS
- Carcinoma, Non-Small-Cell Lung
ELIGIBILITY
Inclusion Criteria:
* Participant must have histologically or cytologically confirmed NSCLC and must have metastatic NSCLC at the time of enrollment
* Participant must have at least 1 measurable lesion, according to RECIST v1.1, that has not been previously irradiated
* May ha
DETAILS
LOCATIONS
| Country (4) | City or Province (15) | Status |
| Taiwan | Taipei City Taipei Medical University |
RECRUITING
|
| United States | Irvine UCI Health Irvine Hospital |
RECRUITING
|
| United States | Los Alamitos Cancer and Blood Specialty Clinic |
RECRUITING
|
| United States | Orange University of California Irvine Medical Center Chao Family Comprehensive Cancer Center |
RECRUITING
|
| United States | Springfield Oncology Hematology Associates |
RECRUITING
|
| United States | Flemington Hunterdon Hematology Oncology |
RECRUITING
|
| United States | Fairfax Virginia Cancer Specialists |
RECRUITING
|
| Taiwan | ChangHua Changhua Christian Hospital |
RECRUITING
|
| Taiwan | Kaohsiung City Kaohsiung Medical University Hospital |
RECRUITING
|
| Taiwan | Liou Ying Township Chi Mei Medical Center Liu Ying |
RECRUITING
|
| Taiwan | Taichung Taichung Veterans General Hospital |
RECRUITING
|
| Taiwan | Taipei National Taiwan University Hospital |
RECRUITING
|
| Türkiye | Cankaya Ankara Bilkent Sehir Hastanesi |
RECRUITING
|
| United Kingdom | Leeds Leeds Teaching Hospitals NHS Trust |
RECRUITING
|
| United Kingdom | Sutton The Royal Marsden NHS Trust |
RECRUITING
|
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51.35, -0.2
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