A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy (OrigAMI-3)
Last Updated February 20, 2025
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61186372COR3002
OVERVIEW
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Sexes Eligible for Study
all -
Age
years -
Phase
phase 33 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus either cetuximab or bevacizumab and FOLFIRI given to participants with Kirsten rat sarcoma viral oncogene/ neuroblastoma RAS viral oncogene homolog (KRAS/ NRAS) and v-raf murine sarcoma viral oncogene homolog B (BRAF) wild-type recurrent, unresectable or metastatic colorectal cancer who have previously received chemotherapy.
CONDITIONS
- Colorectal Neoplasms
ELIGIBILITY
Inclusion Criteria:
* Have histologically or cytologically confirmed adenocarcinoma of the colon or rectum. Participants must have recurrent, unresectable or metastatic disease
* Be diagnosed to have KRAS, NRAS, and BRAF wild-type (WT) tumor as determined by local testing
* Mu
DETAILS
LOCATIONS
| Country (5) | City or Province (14) | Status |
| United States | Los Alamitos Cancer and Blood Specialty Clinic |
RECRUITING
|
| United States | Santa Rosa Providence Medical Foundation |
RECRUITING
|
| United States | Baltimore MedStar Franklin Square Medical Center |
RECRUITING
|
| Australia | Concord Concord Hospital |
RECRUITING
|
| Australia | Heidelberg Warringal Private Hospital |
RECRUITING
|
| Australia | South Woodville Queen Elizabeth Hospital |
RECRUITING
|
| Australia | St Albans Western Health Sunshine Hospital |
RECRUITING
|
| Malaysia | Kuala Lumpur University Malaya Medical Centre |
RECRUITING
|
| Malaysia | Kuching Hospital Umum Sarawak |
RECRUITING
|
| Puerto Rico | Barrio Monacillos Pan American Center for Oncology Trials LLC |
RECRUITING
|
| Taiwan | Kaohsiung Kaohsiung Medical University Chung Ho Memorial Hospital |
RECRUITING
|
| Taiwan | Taipei National Taiwan University Hospital |
RECRUITING
|
| Taiwan | Taipei Taipei Veterans General Hospital |
RECRUITING
|
| Taiwan | Taoyuan Linkou Chang Gung Memorial Hospital |
RECRUITING
|
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