A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy (OrigAMI-3)
Last Updated March 11, 2025
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61186372COR3002
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 33 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus either cetuximab or bevacizumab and FOLFIRI given to participants with Kirsten rat sarcoma viral oncogene/ neuroblastoma RAS viral oncogene homolog (KRAS/ NRAS) and v-raf murine sarcoma viral oncogene homolog B (BRAF) wild-type recurrent, unresectable or metastatic colorectal cancer who have previously received chemotherapy.
CONDITIONS
- Colorectal Neoplasms
ELIGIBILITY
Inclusion Criteria:
* Have histologically or cytologically confirmed adenocarcinoma of the colon or rectum. Participants must have recurrent, unresectable or metastatic disease
* Be diagnosed to have KRAS, NRAS, and BRAF wild-type (WT) tumor as determined by local testing
* Mu
DETAILS
LOCATIONS
Locations in:
United States, Australia, Malaysia, Puerto Rico, Taiwan, Belgium, Brazil, China, France, Germany, Hong Kong, India, Israel, Italy, Japan, South Korea, Netherlands, Poland, Spain, Sweden, Thailand, Türkiye, United Kingdom
| Country (23) | City or Province (103) | Status |
| United States | Los Alamitos Cancer and Blood Specialty Clinic |
RECRUITING
|
| United States | Santa Rosa Providence Medical Foundation |
RECRUITING
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| United States | Baltimore MedStar Franklin Square Medical Center |
RECRUITING
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| Australia | Concord Concord Hospital |
RECRUITING
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| Australia | Heidelberg Warringal Private Hospital |
RECRUITING
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| Australia | South Woodville Queen Elizabeth Hospital |
RECRUITING
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| Australia | St Albans Western Health Sunshine Hospital |
RECRUITING
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| Malaysia | Kuala Lumpur University Malaya Medical Centre |
RECRUITING
|
| Malaysia | Kuching Hospital Umum Sarawak |
RECRUITING
|
| Puerto Rico | Barrio Monacillos Pan American Center for Oncology Trials LLC |
RECRUITING
|
| Taiwan | Kaohsiung Kaohsiung Medical University Chung Ho Memorial Hospital |
RECRUITING
|
| Taiwan | Taipei National Taiwan University Hospital |
RECRUITING
|
| Taiwan | Taipei Taipei Veterans General Hospital |
RECRUITING
|
| Taiwan | Taoyuan Linkou Chang Gung Memorial Hospital |
RECRUITING
|
| United States | Orlando AdventHealth Cancer Institute |
RECRUITING
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| United States | Grand Rapids Cancer And Hematology Centers of Western Michigan PC |
RECRUITING
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| United States | Hattiesburg Hattiesburg Clinic |
RECRUITING
|
| United States | Omaha Nebraska Cancer Specialists |
RECRUITING
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| United States | Houston MD Anderson Cancer Center |
RECRUITING
|
| United States | Lacey Providence Regional Cancer System |
RECRUITING
|
| Belgium | Anderlecht Institut Jules Bordet |
RECRUITING
|
| Belgium | Edegem UZ Antwerpen |
RECRUITING
|
| Belgium | Gent AZ Maria Middelares |
RECRUITING
|
| Belgium | Haine Saint Paul La Louviere Jolimont |
RECRUITING
|
| Belgium | Kortrijk Az Groeninge |
RECRUITING
|
| Belgium | Leuven Universitair Ziekenhuis Leuven |
RECRUITING
|
| Brazil | Barretos Fundacao Pio XII |
RECRUITING
|
| Brazil | Jau Fundacao Doutor Amaral Carvalho |
RECRUITING
|
| Brazil | Sao Paulo Fundacao Antonio Prudente A C Camargo Cancer Center |
RECRUITING
|
| Brazil | Vitoria Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia |
RECRUITING
|
| China | Beijing Peking University First Hospital |
RECRUITING
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| China | Beijing Beijing Cancer Hospital |
RECRUITING
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| China | Chengdu West China Hospital of Sichuan University |
RECRUITING
|
| China | Ganzhou Ganzhou Cancer Hospital |
RECRUITING
|
| China | Guangzhou Sun Yat-Sen University Cancer Center |
RECRUITING
|
| China | Hangzhou The Second Affiliated Hospital of Zhejiang University |
RECRUITING
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| China | Huizhou Huizhou Central People's Hospital |
RECRUITING
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| China | Wuhan Hubei Cancer Hospital |
RECRUITING
|
| France | Avignon Cedex 9 Institut Sainte Catherine |
RECRUITING
|
| Germany | Berlin Charite Universitatsmedizin Berlin Campus Virchow Klinikum |
RECRUITING
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| Germany | Munich Klinikum der Universitaet Muenchen |
RECRUITING
|
| Hong Kong | Shatin Prince Of Wales Hospital |
RECRUITING
|
| India | Delhi Rajiv Gandhi Cancer Institute and Research Centre |
RECRUITING
|
| India | Kolkata B P Poddar Hospital and Medical research Limited |
RECRUITING
|
| India | Pune Deenanath Mangeshkar Hospital and Research Centre |
RECRUITING
|
| Israel | Beer Yaakov Yitzhak Shamir Medical Center |
RECRUITING
|
| Israel | Haifa Rambam Medical Center |
RECRUITING
|
| Israel | Jerusalem Hadassah Medical Center |
RECRUITING
|
| Israel | Petach Tikva Rabin Medical Center |
RECRUITING
|
| Israel | Ramat Gan Sheba Medical Center |
RECRUITING
|
| Israel | Tel Aviv Yafo Tel Aviv Sourasky Medical Center |
RECRUITING
|
| Israel | Tel Aviv Assuta MC |
RECRUITING
|
| Italy | Pisa Azienda Ospedaliero Universitaria Pisana |
RECRUITING
|
| Japan | Chiba Chiba Cancer Center |
RECRUITING
|
| Japan | Chuo Ku National Cancer Center Hospital |
RECRUITING
|
| Japan | Nagoya Shi Aichi Cancer Center |
RECRUITING
|
| Japan | Osaka City Osaka International Cancer Institute |
RECRUITING
|
| Japan | Osaka Sayama shi Kindai University Hospital |
RECRUITING
|
| Japan | Osaka-Shi National Hospital Organization Osaka National Hospital |
RECRUITING
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| Japan | Suita-shi Osaka University Hospital |
RECRUITING
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| Japan | Tokyo The Cancer Institute Hospital of JFCR |
RECRUITING
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| South Korea | Daegu Kyungpook National University Chilgok Hospital |
RECRUITING
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| South Korea | Seoul Korea University Anam Hospital |
RECRUITING
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| South Korea | Seoul Seoul National University Hospital |
RECRUITING
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| South Korea | Seoul Severance Hospital Yonsei University Health System |
RECRUITING
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| South Korea | Seoul Asan Medical Center |
RECRUITING
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| South Korea | Seoul Samsung Medical Center |
RECRUITING
|
| South Korea | Seoul The Catholic University of Korea Seoul St Mary s Hospital |
RECRUITING
|
| Malaysia | Georgetown Hospital Pulau Pinang |
RECRUITING
|
| Malaysia | Ipoh Hospital Raja Permaisuri Bainun |
RECRUITING
|
| Malaysia | Kuala Lumpur Hospital Kuala Lumpur |
RECRUITING
|
| Malaysia | Putrajaya Institut Kanser Negara Clinical Research Center |
RECRUITING
|
| Netherlands | Amersfoort Meander Medisch Centrum |
RECRUITING
|
| Netherlands | Nijmegen Radboud University Medical Center |
RECRUITING
|
| Netherlands | Tilburg ETZ TweeSteden |
RECRUITING
|
| Poland | Brzozow Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza |
RECRUITING
|
| Poland | Gdansk Uniwersyteckie Centrum Kliniczne |
RECRUITING
|
| Poland | Gliwice Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach |
RECRUITING
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| Poland | Lodz Instytut Centrum Zdrowia Matki Polki |
RECRUITING
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| Poland | Olsztyn SPZOZ Ministerstwa Spraw Wewnetrznych z Warminsko Mazurskim Centrum Onkologii w Olsztynie |
RECRUITING
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| Poland | Opole SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego |
RECRUITING
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| Poland | Warszawa Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy |
RECRUITING
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| Spain | Barcelona Hosp. de La Santa Creu I Sant Pau |
RECRUITING
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| Spain | Barcelona Hosp Univ Vall D Hebron |
RECRUITING
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| Spain | Madrid Hosp. Univ. Ramon Y Cajal |
RECRUITING
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| Spain | Pamplona Clinica Univ. de Navarra |
RECRUITING
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| Spain | Sevilla Hosp. Virgen Del Rocio |
RECRUITING
|
| Spain | Valencia Hosp. Clinico Univ. de Valencia |
RECRUITING
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| Sweden | Gothenburg Sahlgrenska Universitetssjukhuset |
RECRUITING
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| Sweden | Lund Skanes universitetssjukhus |
RECRUITING
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| Sweden | Stockholm Sodersjukhuset |
RECRUITING
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| Sweden | Stockholm Karolinska Universitetssjukhuset |
RECRUITING
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| Sweden | Uppsala Uppsala University |
RECRUITING
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| Taiwan | Kaohsiung City Chang Gung Memorial Hospital |
RECRUITING
|
| Taiwan | Taichung Taichung Veterans General Hospital |
RECRUITING
|
| Taiwan | Tainan National Cheng Kung University Hospital |
RECRUITING
|
| Thailand | Bangkok Ramathibodi Hospital |
RECRUITING
|
| Thailand | Bangkok Siriraj Hospital |
RECRUITING
|
| Thailand | Chiang Mai Chiang Mai University |
RECRUITING
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| Thailand | Songkhla Songklanagarind hospital |
RECRUITING
|
| Türkiye | Ankara Gazi University Hospital |
RECRUITING
|
| Türkiye | Konya Necmettin Erbakan University Meram Medical Faculty |
RECRUITING
|
| United Kingdom | London St Bartholomew's Hospital |
RECRUITING
|
Geo Locations
33.80307, -118.07256
38.44047, -122.71443
39.29038, -76.61219
-33.84722, 151.10381
-37.75, 145.06667
-34.8789633, 138.5369358
-37.73901, 144.80024
3.1412, 101.68653
1.54999, 110.33333
18.4499141, -66.0603497
22.61626, 120.31333
25.04776, 121.53185
25.04776, 121.53185
24.95233, 121.20193
28.53834, -81.37924
42.96336, -85.66809
31.32712, -89.29034
41.25626, -95.94043
29.76328, -95.36327
47.03426, -122.82319
50.83619, 4.31454
51.15662, 4.44504
51.05, 3.71667
50.45313, 4.19126
50.82803, 3.26487
50.87959, 4.70093
-20.55722, -48.56778
-22.29639, -48.55778
-23.5475, -46.63611
-20.31944, -40.33778
39.9075, 116.39723
39.9075, 116.39723
30.66667, 104.06667
25.8528899, 114.94
23.11667, 113.25
30.29365, 120.16142
23.11147, 114.41523
30.58333, 114.26667
43.94834, 4.80892
52.52437, 13.41053
48.13743, 11.57549
22.38333, 114.18333
28.65195, 77.23149
22.56263, 88.36304
18.51957, 73.85535
31.943507, 34.83904
32.81841, 34.9885
31.76904, 35.21633
32.08707, 34.88747
32.08227, 34.81065
32.08088, 34.78057
32.08088, 34.78057
43.70853, 10.4036
35.6, 140.11667
35.57779, 139.71685
35.18147, 136.90641
34.69374, 135.50218
34.69374, 135.50218
34.69374, 135.50218
34.76143, 135.51567
35.6895, 139.69171
35.87028, 128.59111
37.566, 126.9784
37.566, 126.9784
37.566, 126.9784
37.566, 126.9784
37.566, 126.9784
37.566, 126.9784
5.4197312, 100.3170452
4.5841, 101.0829
3.1412, 101.68653
2.93527, 101.69112
52.155, 5.3875
51.8425, 5.85278
51.55551, 5.0913
49.69501, 22.01926
54.35205, 18.64637
50.29761, 18.67658
51.75, 19.46667
53.77995, 20.49416
50.67211, 17.92533
52.22977, 21.01178
41.38879, 2.15899
41.38879, 2.15899
40.4165, -3.70256
42.81687, -1.64323
37.38283, -5.97317
39.46975, -0.37739
57.70716, 11.96679
55.70584, 13.19321
59.33258, 18.0649
59.33258, 18.0649
59.85882, 17.63889
22.61626, 120.31333
24.1469, 120.6839
22.99083, 120.21333
13.75398, 100.50144
13.75398, 100.50144
18.79038, 98.98468
7.19882, 100.5951
39.91987, 32.85427
37.87135, 32.48464
51.50853, -0.12574
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