Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib (COCOON)
Last Updated February 21, 2025
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61186372NSC2007
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 22 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to evaluate whether enhanced dermatologic management can reduce incidence of grade greater than or equal to (>=) 2 dermatologic adverse events of interest (DAEIs) when compared with standard-of-care skin management in participants with locally advanced or metastatic stage IIIB/C-IV epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) treated first-line with amivantamab and lazertinib.
CONDITIONS
- Carcinoma, Non-Small-Cell Lung
ELIGIBILITY
Inclusion Criteria:
* Have histologically or cytologically confirmed, locally advanced or metastatic non-small cell lung cancer (NSCLC) that is treatment-naive and not amenable to curative therapy including surgical resection or (chemo) radiation. Adjuvant or neoadjuvant therapy for
DETAILS
LOCATIONS
Country (11) | City or Province (78) | Status |
United States | Duarte City of Hope |
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United States | Huntington Beach City of Hope Seacliff |
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United States | Irvine City of Hope Orange County Lennar Foundation Cancer Center |
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United States | Long Beach City of Hope Long Beach Elm |
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United States | Los Alamitos Cancer and Blood Specialty Clinic |
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United States | Los Angeles Keck Hospital of USC |
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United States | Newport Beach USC Norris Oncology Hematology Newport Beach |
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United States | South Pasadena City of Hope South Pasadena |
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United States | Hinsdale Hope and Healing Care |
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United States | Springfield Oncology Hematology Associates |
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United States | Reno Renown Regional Medical Center |
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United States | Flemington Hunterdon Hematology Oncology |
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United States | Westbury Clinical Research Alliance Inc |
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United States | Wilson Regional Medical Oncology Center |
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United States | Cleveland University Hospitals Cleveland Medical Center |
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United States | Fairfax Virginia Cancer Specialists |
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United States | Renton Valley Medical Center |
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United States | W. Salem Gundersen Health System |
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Argentina | Buenos Aires Hospital Italiano de Buenos Aires |
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Argentina | Caba IADT Instituto Argentino de Diagnostico y Tratamiento |
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Argentina | Capital Federal Centro Medico Austral |
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Argentina | La Plata Hospital Italiano de La Plata |
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Argentina | Mar del Plata Hospital Privado de la Comunidad |
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Brazil | Belo Horizonte Santa Casa de Misericordia de Belo Horizonte |
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Brazil | Curitiba Liga Paranaense de Combate ao Cancer |
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Brazil | Jaú Fundacao Doutor Amaral Carvalho |
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Brazil | Porto Alegre Hospital Nossa Senhora da Conceicao S A |
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Brazil | Sao Paulo Fundacao Antonio Prudente A C Camargo Cancer Center |
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Brazil | Taubate Servicos de Tratamento ao Cancer de Taubate LTDA - Instituto do Cancer Brasil Unidade Taubate |
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Brazil | Vitoria Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia |
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China | Changzhou Changzhou No 2 Peoples Hospital |
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China | Chengdou West China Hospital |
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China | Chengdu Sichuan Cancer Hospital |
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China | Guang Zhou The First Affiliated Hospital Sun Yat sen University |
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China | Hangzhou The First Affiliated Hospital Zhejiang University College of Medicine |
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China | Harbin Harbin medical university cancer hospital |
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China | Huizhou Huizhou Municipal Central Hospital |
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China | Nanjing Zhongda Hospital Southeast University |
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China | ShangHai Fudan University Shanghai Cancer Center |
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China | Zhengzhou Henan Cancer Hospital |
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France | Marseille Cedex 20 Hopital Nord |
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France | Nice Hopital PASTEUR |
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France | Paris Institut Curie |
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Germany | Aachen Universitaetsklinikum der RWTH Aachen |
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Germany | Essen Kliniken Essen-Mitte |
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Germany | Giessen Universitaetsklinikum Giessen und Marburg GmbH |
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Germany | Heidelberg Thoraxklinik am Universitatsklinikum Heidelberg |
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Germany | Kassel Klinikum Kassel GmbH |
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Germany | Kiel Universitaetsklinikum Schleswig Holstein Campus Kiel |
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South Korea | Cheongju-si Chungbuk National University Hospital |
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South Korea | Incheon Gachon University Gil Hospital |
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South Korea | Seoul Severance Hospital Yonsei University Health System |
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Malaysia | Georgetown Hospital Pulau Pinang |
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Malaysia | Kuala Lumpur University Malaya Medical Centre |
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Malaysia | Kuantan Hospital Tengku Ampuan Afzan |
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Malaysia | Kuching Hospital Umum Sarawak |
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Spain | A Coruna Hosp. Univ. A Coruna |
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Spain | Alicante Hosp. Gral. Univ. de Alicante |
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Spain | Barcelona Hosp. Univ. Quiron Dexeus |
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Spain | Barcelona Hosp Univ Vall D Hebron |
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Spain | Jaen Hosp. Univ. de Jaen |
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Spain | Lugo Hosp. Univ. Lucus Augusti |
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Spain | Madrid Hosp. Gral. Univ. Gregorio Maranon |
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Spain | Malaga Hosp. Regional Univ. de Malaga |
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Spain | Sevilla Hosp. Ntra. Sra. de Valme |
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Taiwan | Hsin Chu National Taiwan University Hospital Hsin Chu Branch |
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Taiwan | Kaohsiung City Chang Kung Memorial Hospital |
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Taiwan | Taichung City Taichung Veterans General Hospital |
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Taiwan | Taipei National Taiwan University Hospital |
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Taiwan | Taoyuan City Linkou Chang Gung Memorial Hospital |
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Türkiye | Adana Adana City Hospital |
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Türkiye | Ankara Gulhane Training and Research Hospital |
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Türkiye | Ankara Gazi University Hospital |
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Türkiye | Ankara Ankara Bilkent City Hospital |
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Türkiye | Istanbul Bakirkoy Training and Research Hospital |
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Türkiye | Istanbul I A U VM Medical Park Florya Hastanesi |
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Türkiye | Izmir Ege University Medical Faculty |
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Türkiye | Samsun Ondokuz Mayis University |
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