A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide (MonumenTAL-6)
Last Updated May 9, 2025
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64407564MMY3009
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 33 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to compare the effectiveness of either talquetamab plus pomalidomide (Tal-P) or talquetamab plus teclistamab (Tal-Tec) with elotuzumab, pomalidomide, and dexamethasone (EPd) or pomalidomide, bortezomib, and dexamethasone (PVd).
CONDITIONS
- Relapsed or Refractory Multiple Myeloma
ELIGIBILITY
Inclusion Criteria:
* Documented multiple myeloma as defined by the criteria below: (a) multiple myeloma diagnosis according to the international myeloma working group (IMWG) diagnostic criteria (b) measurable disease at screening as assessed by central laboratory, defined by any of
DETAILS
LOCATIONS
Locations in:
United States, Argentina, Australia, Austria, Belgium, Brazil, Canada, China, Czechia, Denmark, France, Germany, Greece, Hungary, India, Israel, Italy, Japan, South Korea, Netherlands, Poland, Saudi Arabia, Spain, Sweden, Türkiye, United Kingdom
| Country (26) | City or Province (212) | Status |
| United States | New Haven Yale University School Of Medicine |
RECRUITING
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| United States | Saint Paul Regions Hospital |
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| United States | Cleveland Cleveland Clinic |
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| United States | Pittsburgh West Penn Hospital |
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| Argentina | Buenos Aires Fundaleu |
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| Argentina | Buenos Aires Hospital Aleman |
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| Argentina | Ciudad Autonoma de Buenos Aires Hospital Britanico de Buenos Aires |
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| Australia | Adelaide Royal Adelaide Hospital |
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| Australia | Box Hill Box Hill Hospital |
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| Australia | Darlinghurst St Vincents Hospital |
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| Australia | Fitzroy St Vincents Hospital Melbourne |
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| Australia | Southport Gold Coast University Hospital |
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| Australia | West Perth Perth Blood Institute |
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| Australia | Wollongong Wollongong Hospital |
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| Austria | Salzburg LKH - Universitätsklinikum der PMU Salzburg |
RECRUITING
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| Belgium | Genk Ziekenhuis Oost-Limburg |
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| Belgium | Gent Ghent University Hospital |
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| Belgium | Sint-Niklaas AZ Nikolaas - Campus Sint-Niklaas Moerland |
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| Brazil | Belo Horizonte Cetus Oncologia |
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| Brazil | Brasilia DF Star |
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| Brazil | Caxias do Sul Fundacao Universidade de Caxias do Sul |
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| Brazil | Curitiba Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer |
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| Brazil | Recife Instituto D Or de Pesquisa e Ensino IDOR |
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| Brazil | Rio de Janeiro Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI) |
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| Brazil | Sao Paulo Real e Benemerita Associacao Portuguesa de Beneficencia |
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| Brazil | Sao Paulo Fundacao Antonio Prudente A C Camargo Cancer Center |
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| Canada | Hamilton Juravinski Cancer Centre |
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| Canada | Montreal CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont |
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| Canada | Saskatoon Saskatoon Cancer Centre |
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| China | Beijing Beijing Chaoyang Hospital |
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| China | Beijing Peking University First Hospital |
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| China | Beijing Peking University People s Hospital |
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| China | Changzhou Changzhou No 2 Peoples Hospital |
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| China | Guangzhou Sun Yat-Sen University Cancer Center |
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| China | Guangzhou Nanfang Hospital of Southern Medical Hospital |
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| China | Hangzhou First hospital affiliated of Zhejiang Medical university |
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| China | Hangzhou The Second Affiliated Hospital of Zhejiang University College of Medicine |
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| China | Jinan Qilu Hospital of Shandong University |
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| China | Nanchang The First Affiliated Hospital of NanChang University |
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| China | Shanghai Shanghai Fourth People s Hospital |
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| China | Shenyang Shengjing Hospital Of China Medical University |
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| China | Shenzhen Peking University Shenzhen Hospital |
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| China | Tianjin Tianjin Medical University Cancer Institute and Hospital |
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| China | Wenzhou The First Affiliated Hospital of Wenzhou Medical University |
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| China | Wuhan Tongji Hospital, Tongji Medical College of HUST |
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| Czechia | Brno - Bohunice Fakultni nemocnice Brno |
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| Czechia | Hradec Kralove Fakultni nemocnice Hradec Kralove |
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| Czechia | Olomouc University Hospital Olomouc |
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| Czechia | Ostrava Fakultni Nemocnice Ostrava |
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| Denmark | Aarhus Aarhus University Hospital |
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| Denmark | Odense C Odense University Hospital |
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| Denmark | Vejle Vejle Hospital |
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| France | Lille Hopital Claude Huriez |
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| France | Limoges CHU de Limoges Hopital Dupuytren |
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| France | Marseille Institut Paoli Calmettes |
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| France | Nantes CHU Nantes |
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| France | Paris Hopital Saint Louis |
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| France | Pessac Cedex CHU de Bordeaux - Hospital Haut-Leveque |
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| France | Strasbourg Institut de Cancerologie Strasbourg Europe ICANS |
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| France | Toulouse Cedex 9 Institut Universitaire du Cancer Toulouse Oncopole |
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| France | TOURS Cedex 01 CHRU Tours Hopital Bretonneau |
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| Germany | Augsburg Klinikum Augsburg |
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| Germany | Halle (Saale) Universitaetsklinikum Halle Saale |
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| Germany | Heidelberg Universitaetsklinikum Heidelberg |
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| Germany | Magdeburg Universitaetsklinikum Magdeburg A.oe.R |
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| Germany | Tuebingen Universitaetsklinikum Tuebingen |
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| Germany | Würzburg Universitaetsklinikum Wuerzburg |
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| Greece | Athens 251 Airforces Hospital |
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| Greece | Athens Alexandra General Hospital of Athens |
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| Greece | Thessaloniki Anticancer Hospital of Thessaloniki Theageneio |
RECRUITING
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| Hungary | Budapest Semmelweis Egyetem, Belgyogyaszati es Hematologiai Klinika |
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| Hungary | Pecs Pecsi Tudomanyegyetem Klinikai Kozpont |
RECRUITING
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| India | Gurgaon Fortis Memorial Research Institute |
RECRUITING
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| India | Pune Deenanath Mangeshkar Hospital and Research Centre |
RECRUITING
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| Israel | Haifa Carmel Medical Center |
RECRUITING
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| Israel | Petah-Tikva Rabin Medical center - Petah-Tikva |
RECRUITING
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| Israel | Ramat Gan Sheba Medical Center |
RECRUITING
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| Israel | Tel Aviv-Yafo Tel Aviv Sourasky Medical Center |
RECRUITING
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| Italy | Alessandria Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria |
RECRUITING
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| Italy | Brindisi oncologia medica - Oncology |
RECRUITING
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| Italy | Catania ARNAS Garibaldi P O Nesima |
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| Italy | Genova Ospedale Policlinico San Martino IRCCS |
RECRUITING
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| Italy | Legnano Asst Ovest Milanese - Ospedale Di Legnano |
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| Italy | Milano Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano |
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| Italy | Milano IRCCS Ospedale San Raffaele |
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| Italy | Pavia Fondazione IRCCS Policlinico San Matteo |
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| Italy | Pescara Presidio Ospedaliero Pescara |
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| Italy | Ravenna Ospedale S. Maria Delle Croci |
RECRUITING
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| Italy | Torino Oncologia Medica-Città Della Salute E Della Scienza Di Torino |
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| Italy | Verona Azienda Ospedaliera Universitaria Integrata Verona |
RECRUITING
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| Japan | Bunkyo Ku Juntendo University Hospital |
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| Japan | Fukuoka Fukuoka University Hospital |
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| Japan | Kyoto University Hospital Kyoto Prefectural University of Medicine |
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| Japan | Nagasaki National Hospital Organization Nagasaki Medical Center |
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| Japan | Narita Japanese Red Cross Narita Hospital |
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| Japan | Niigata Niigata Cancer Center Hospital |
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| Japan | Osaka Japanese Red Cross Osaka Hospital |
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| Japan | Sapporo Sapporo City General Hospital |
RECRUITING
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| Japan | Shibuya-ku Japanese Red Cross Medical Center |
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| Japan | Shiwa-gun Iwate Medical University Hospital |
RECRUITING
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| Japan | Suita-City Osaka University Hospital |
RECRUITING
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| Japan | Tottori Tottori University Hospital |
RECRUITING
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| Japan | Tsukuba University of Tsukuba Hospital |
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| Japan | Yokohama City Kanagawa Cancer Center |
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| South Korea | Busan Dong-A University Hospital |
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| South Korea | Busan Pusan National University Hospital |
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| South Korea | Jeollanam-do Chonnam National University Hwasun Hospital |
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| South Korea | Seoul Seoul National University Hospital |
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| South Korea | Seoul Samsung Medical Center |
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| South Korea | Seoul The Catholic University of Korea Seoul St Mary s Hospital |
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| South Korea | Ulsan Ulsan University Hospital |
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| Netherlands | Almere Flevoziekenhuis |
RECRUITING
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| Netherlands | Den Haag Haga ziekenhuis |
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| Netherlands | Eindhoven Catharinaziekenhuis |
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| Netherlands | Nieuwegein St. Antonius Ziekenhuis Nieuwegein |
RECRUITING
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| Netherlands | Zwolle Isala Kliniek |
RECRUITING
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| Poland | Biala Podlaska Wojewodzki Szpital Specjalistyczny |
RECRUITING
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| Poland | Brzozow Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza |
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| Poland | Lublin Centrum Onkologii Ziemii Lubelskiej |
RECRUITING
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| Poland | Szczecin Uniwersytecki Szpital Kliniczny Nr 1 PUM im prof Tadeusza Sokolowskiego w Szczecinie |
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| Saudi Arabia | Riyadh King Faisal Specialist Hospital & Research Center |
RECRUITING
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| Saudi Arabia | Riyadh King Fahad Medical City |
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| Spain | Asturias Hosp. de Cabuenes |
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| Spain | Barcelona Hosp Univ Vall D Hebron |
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| Spain | Burgos Hosp. Univ. de Burgos |
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| Spain | Cáceres Hosp. San Pedro de Alcantara |
RECRUITING
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| Spain | Granada Hosp. Univ. Virgen de Las Nieves |
RECRUITING
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| Spain | Lugo Hosp. Univ. Lucus Augusti |
RECRUITING
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| Spain | Madrid Hosp. Univ. La Paz |
RECRUITING
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| Spain | Palma de Mallorca Hosp. Univ. Son Espases |
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| Spain | Pamplona Clinica Univ. de Navarra |
RECRUITING
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| Spain | Pamplona Complejo Hosp de Navarra - Hosp de Navarra |
RECRUITING
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| Spain | Salamanca Hosp Clinico Univ de Salamanca |
RECRUITING
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| Spain | San Sebastian Hosp. Univ. Donostia |
RECRUITING
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| Spain | Santander Hosp. Univ. Marques de Valdecilla |
RECRUITING
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| Spain | Santiago de Compostela Hosp. Clinico Univ. de Santiago |
RECRUITING
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| Sweden | Lund Skanes universitetssjukhus |
RECRUITING
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| Sweden | Uppsala Akademiska Sjukhuset |
RECRUITING
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| Sweden | Varberg Varberg Hospital |
RECRUITING
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| Türkiye | Ankara Ankara University Medical Faculty |
RECRUITING
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| Türkiye | Ankara Liv Hospital Ankara |
RECRUITING
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| Türkiye | Denizli Pamukkale University Medical Faculty |
RECRUITING
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| Türkiye | Istanbul Medipol University Hospital |
RECRUITING
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| Türkiye | Samsun Ondokuz Mayis University |
RECRUITING
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| United Kingdom | Cardiff University Hospital of Wales |
RECRUITING
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| United Kingdom | Dundee Ninewells Hospital |
RECRUITING
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| United Kingdom | Plymouth University Hospitals Plymouth NHS Trust |
RECRUITING
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| United Kingdom | Portsmouth Queen Alexandra Hospital |
RECRUITING
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| United States | Clovis UCSF Fresno |
RECRUITING
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| United States | Hollywood Memorial Healthcare System |
RECRUITING
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| United States | Tampa Moffitt Cancer Center |
RECRUITING
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| United States | Atlanta Winship Cancer Institute Emory University |
RECRUITING
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| United States | Coeur d'Alene Kootenai Health |
RECRUITING
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| United States | Des Moines Mission Cancer and Blood Medical Oncology and Hematology Associates of Iowa |
RECRUITING
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| United States | Louisville Norton Cancer Institute |
RECRUITING
|
| United States | Annapolis Luminis Health Center for Cancer and Blood Disorders |
RECRUITING
|
| United States | Baltimore The Sidney Kimmel Comprehensive Cancer Center at John Hopkins |
RECRUITING
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| United States | Southfield Ascension Providence Hospital |
RECRUITING
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| United States | Minneapolis University Of Minnesota |
RECRUITING
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| United States | Omaha University of Nebraska |
RECRUITING
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| United States | Lebanon Dartmouth Hitchcock Medical Center |
RECRUITING
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| United States | Buffalo Roswell Park Cancer Institute |
RECRUITING
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| United States | Syracuse SUNY Upstate Medical University |
RECRUITING
|
| United States | Cleveland Louis Stokes Cleveland VA Med Ctr |
RECRUITING
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| United States | Portland Oregon Health And Science University |
RECRUITING
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| United States | Philadelphia Thomas Jefferson University |
RECRUITING
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| United States | Pittsburgh University Of Pittsburgh Medical Center UPMC Hillman Cancer Center |
RECRUITING
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| United States | Greenville Bon Secours Saint Francis Cancer Center |
RECRUITING
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| United States | Houston Houston Methodist Neal Cancer Center at Texas Medical Center |
RECRUITING
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| United States | Salt Lake City Huntsman Cancer Institute |
RECRUITING
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| United States | Charlottesville University of Virginia |
RECRUITING
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| United States | Seattle Swedish Cancer Institute |
RECRUITING
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| United States | Seattle Fred Hutchinson Cancer Research Center |
RECRUITING
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| Austria | Vienna Medical University Vienna MUV |
RECRUITING
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| Belgium | Charleroi Grand Hopital De Charleroi Site Les Viviers |
RECRUITING
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| Brazil | Porto Alegre Hospital De Clinicas De Porto Alegre |
RECRUITING
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| Brazil | Salvador Hospital Sao Rafael |
RECRUITING
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| Brazil | Sao Jose do Rio Preto Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base |
RECRUITING
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| Brazil | Sao Paulo Clinica Medica Sao Germano S/S LTDA |
RECRUITING
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| Brazil | Sao Paulo Instituto D Or de Pesquisa e Ensino |
RECRUITING
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| Canada | Calgary Arthur J E Child Comprehensive Cancer Centre |
RECRUITING
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| Canada | Vancouver British Columbia Cancer Agency |
RECRUITING
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| Canada | Halifax Nova Scotia Health Authority |
RECRUITING
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| Canada | Toronto Princess Margaret Cancer Centre University Health Network |
RECRUITING
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| China | Changsha The Second Xiangya Hospital of Central South Hospital |
RECRUITING
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| China | Chengdu Sichuan Provincial Peoples Hospital |
RECRUITING
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| China | Fuzhou Fujian Meidical University Union Hospital |
RECRUITING
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| China | Nan Ning Shi The First Affiliated Hospital of Guangxi Medical University |
RECRUITING
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| China | Nanjing Nanjing Drum Tower Hospital |
RECRUITING
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| China | Shanghai Ruijing Hospital Affiliated To Shanghai Jiaotong University School Of Medicine |
RECRUITING
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| China | Shanghai Tongji Hospital of Tongji University |
RECRUITING
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| China | Su Zhou First Affiliated Hospital SooChow University |
TERMINATED
|
| China | Xi'an The Second Affiliated Hospital of Xi'an Jiaotong University |
RECRUITING
|
| France | Pierre Benite CHU Lyon Sud |
RECRUITING
|
| Germany | München Klinikum rechts der Isar der TU Muenchen |
COMPLETED
|
| Hungary | Debrecen Debreceni Egyetem Klinikai Kozpont |
RECRUITING
|
| Hungary | Nyiregyhaza Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz |
RECRUITING
|
| India | Lucknow Sanjay Gandhi Postgraduate Institute of Medical Sciences |
RECRUITING
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| Israel | Be'er Ya'akov Shamir Medical Center Assaf Harofeh |
RECRUITING
|
| Japan | Hamamatsu Hamamatsu University Hospital |
RECRUITING
|
| Japan | Kanazawa Kanazawa University Hospital |
RECRUITING
|
| Japan | Nishinomiya shi Hyogo Medical University Hospital |
RECRUITING
|
| Japan | Sendai Tohoku University Hospital |
RECRUITING
|
| Japan | Sunto Gun Shizuoka Cancer Center |
RECRUITING
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| Japan | Tokyo The Cancer Institute Hospital of JFCR |
RECRUITING
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| Poland | Kielce Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach |
RECRUITING
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| Poland | Wroclaw Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu |
RECRUITING
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| Saudi Arabia | Riyadh King Abdullah International Medical Research Center (KAIMRC) |
RECRUITING
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| Sweden | Umea Norrlands Universitetssjukhus |
RECRUITING
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| United Kingdom | Leeds St James University Hospital |
RECRUITING
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| United Kingdom | London Kings College Hospital |
RECRUITING
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| United Kingdom | Nottingham Nottingham City Hospital |
RECRUITING
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Geo Locations
41.30815, -72.92816
44.94441, -93.09327
41.4995, -81.69541
40.44062, -79.99589
-34.61315, -58.37723
-34.61315, -58.37723
-34.61315, -58.37723
-34.92866, 138.59863
-37.81887, 145.12545
-33.87939, 151.21925
-37.79839, 144.97833
-27.96724, 153.39796
-31.94896, 115.84199
-34.424, 150.89345
47.79941, 13.04399
50.965, 5.50082
51.05, 3.71667
51.16509, 4.1437
-19.92083, -43.93778
-15.77972, -47.92972
-29.16806, -51.17944
-25.42778, -49.27306
-8.05389, -34.88111
-22.90278, -43.2075
-23.5475, -46.63611
-23.5475, -46.63611
43.25011, -79.84963
45.50884, -73.58781
52.13238, -106.66892
39.9075, 116.39723
39.9075, 116.39723
39.9075, 116.39723
31.77359, 119.95401
23.11667, 113.25
23.11667, 113.25
30.29365, 120.16142
30.29365, 120.16142
36.66833, 116.99722
28.68396, 115.85306
31.22222, 121.45806
41.79222, 123.43278
22.54554, 114.0683
39.14222, 117.17667
27.99942, 120.66682
30.58333, 114.26667
49.1693374, 16.5792118
50.20923, 15.83277
49.59552, 17.25175
49.83465, 18.28204
56.15674, 10.21076
55.39594, 10.38831
55.70927, 9.5357
50.63297, 3.05858
45.83153, 1.25781
43.29551, 5.38958
47.21725, -1.55336
48.85341, 2.3488
44.81011, -0.64129
48.58392, 7.74553
43.60426, 1.44367
47.38333, 0.68333
48.37154, 10.89851
51.48159, 11.97948
49.40768, 8.69079
52.12773, 11.62916
48.52266, 9.05222
49.79391, 9.95121
37.97945, 23.71622
37.97945, 23.71622
40.64361, 22.93086
47.49801, 19.03991
46.08333, 18.23333
28.4601, 77.02635
18.51957, 73.85535
32.81841, 34.9885
32.08707, 34.88747
32.08227, 34.81065
32.08088, 34.78057
44.90924, 8.61007
40.63215, 17.93607
37.49223, 15.07041
44.40478, 8.94438
45.59788, 8.91506
45.46427, 9.18951
45.46427, 9.18951
45.19205, 9.15917
42.4584, 14.20283
44.41344, 12.20121
45.07049, 7.68682
45.4299, 10.98444
35.37517, 139.92991
33.6, 130.41667
35.02107, 135.75385
32.75, 129.88333
35.78333, 140.31667
37.88637, 139.00589
34.69374, 135.50218
43.06667, 141.35
35.469, 140.29807
33.23058, 133.24871
34.76143, 135.51567
35.5, 134.23333
36.2, 140.1
35.43333, 139.65
35.10278, 129.04028
35.10278, 129.04028
35.056264, 127.0025403
37.566, 126.9784
37.566, 126.9784
37.566, 126.9784
35.53722, 129.31667
52.37535, 5.25295
52.07667, 4.29861
51.44083, 5.47778
52.02917, 5.08056
52.5125, 6.09444
52.03238, 23.11652
49.69501, 22.01926
51.25, 22.56667
53.42894, 14.55302
24.68773, 46.72185
24.68773, 46.72185
43.5151142, -5.5984925
41.38879, 2.15899
42.34106, -3.70184
39.47649, -6.37224
37.18817, -3.60667
43.00992, -7.55602
40.4165, -3.70256
39.56939, 2.65024
42.81687, -1.64323
42.81687, -1.64323
40.96882, -5.66388
43.31283, -1.97499
43.46472, -3.80444
42.88052, -8.54569
55.70584, 13.19321
59.85882, 17.63889
57.10557, 12.25078
39.91987, 32.85427
39.91987, 32.85427
37.77417, 29.0875
41.01384, 28.94966
41.27976, 36.3361
51.48, -3.18
56.46913, -2.97489
50.37153, -4.14305
50.79899, -1.09125
36.82523, -119.70292
26.0112, -80.14949
27.94752, -82.45843
33.749, -84.38798
47.67768, -116.78047
41.60054, -93.60911
38.25424, -85.75941
38.97845, -76.49218
39.29038, -76.61219
42.47337, -83.22187
44.97997, -93.26384
41.25626, -95.94043
43.64229, -72.25176
42.88645, -78.87837
43.04812, -76.14742
41.4995, -81.69541
45.52345, -122.67621
39.95233, -75.16379
40.44062, -79.99589
34.85262, -82.39401
29.76328, -95.36327
40.76078, -111.89105
38.02931, -78.47668
47.60621, -122.33207
47.60621, -122.33207
48.20849, 16.37208
50.41136, 4.44448
-30.03306, -51.23
-12.97111, -38.51083
-20.81972, -49.37944
-23.5475, -46.63611
-23.5475, -46.63611
51.05011, -114.08529
49.24966, -123.11934
44.64533, -63.57239
43.70011, -79.4163
28.19874, 112.97087
30.66667, 104.06667
26.06139, 119.30611
22.7975999, 108.361
32.06167, 118.77778
31.22222, 121.45806
31.22222, 121.45806
31.3120999, 120.631
34.25833, 108.92861
45.7009, 4.82511
48.13743, 11.57549
47.53333, 21.63333
47.95539, 21.71671
26.83928, 80.92313
31.943507, 34.83904
34.7, 137.73333
36.6, 136.61667
34.71562, 135.33199
38.26667, 140.86667
35.1565356, 138.8845111
35.6895, 139.69171
50.87033, 20.62752
51.1, 17.03333
24.68773, 46.72185
63.82842, 20.25972
53.79648, -1.54785
51.50853, -0.12574
52.9536, -1.15047
x
50
Indicates 50+ sites in this region: click to zoom in.
10
Indicates 10+ sites in this region: click to zoom in.
5
Indicates < 10 sites in this region: click to zoom in.
Corresponds to individual site.