A Study to Evaluate Preventive Treatments for Talquetamab-related Oral Toxicity (Talisman)
Last Updated February 22, 2025
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64407564MMY2006
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 22 -
Sites
Sites -
Status
Not yet recruiting
SUMMARY
The purpose of this study is to identify preventive treatments that can minimize the occurrence, severity, and duration of talquetamab-related taste dysfunction (hypogeusia), during the study treatment phase, and to better characterize the signs or symptoms of talquetamab-related taste dysfunction.
CONDITIONS
- Relapse Multiple Myeloma
- Refractory Multiple Myeloma
ELIGIBILITY
Inclusion Criteria:
* Multiple myeloma (MM) according to IMWG diagnostic criteria
* Were triple-class exposed (received prior treatment with a PI, an IMiD, and anti CD38 mAb)
* Documented evidence of progressive disease based on investigator's determination of response by IMWG
DETAILS
LOCATIONS
| Country (7) | City or Province (49) | Status |
| Belgium | Leuven UZ Leuven |
COMPLETED
|
| Belgium | Yvoir Ucl de Mont-Godinne |
COMPLETED
|
| France | Lille CHRU de Lille Hopital Claude Huriez |
COMPLETED
|
| France | Montpellier Cedex 5 CHU de Montpellier Hopital Saint Eloi |
ACTIVE_NOT_RECRUITING
|
| France | Nantes Cedex 1 CHU de Nantes hotel Dieu |
COMPLETED
|
| France | Pierre-Bénite Centre hospitalier Lyon-Sud |
COMPLETED
|
| France | Toulouse cedex 9 Pôle IUC Oncopole CHU |
ACTIVE_NOT_RECRUITING
|
| Germany | Berin Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin |
RECRUITING
|
| Germany | Dresden Universitatsklinikum Carl Gustvav Carus Dresden an der Technischen Universitat Dresden |
RECRUITING
|
| Germany | Hamburg Universitätsklinik Hamburg-Eppendorf - Orthopädische Universitätsklinik und Poliklinik |
RECRUITING
|
| Germany | Hamm St. Barbara-Klinik Hamm GmbH |
RECRUITING
|
| Germany | Heidelberg Universitaetsklinikum Heidelberg |
RECRUITING
|
| Germany | Koeln Universitaetsklinikum Koeln |
RECRUITING
|
| Germany | Leipzig Universitaetsklinikum Leipzig |
RECRUITING
|
| Germany | Tubingen Klinikum der Eberhard Karls Universitaet Abt fur innere Med II Haematologie Onkologie Germany |
RECRUITING
|
| Germany | Wuerzburg Universitatsklinikum Wurzburg |
RECRUITING
|
| Italy | Bari U.O. Ematologia Istituto Tumori Giovanni Paolo II |
COMPLETED
|
| Italy | Bologna Istituto di Ematologia Seràgnoli azienda ospedaliera univeristaria Policlinico S.Orsola-Malpighi |
ACTIVE_NOT_RECRUITING
|
| Italy | Catania Policlinico di Catania |
ACTIVE_NOT_RECRUITING
|
| Italy | Genova IRCCS Azienda Ospedaliera San Martino - IST |
COMPLETED
|
| Italy | Meldola Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori |
ACTIVE_NOT_RECRUITING
|
| Italy | Padova Universita degli Studi di Padova Azienda Ospedaliera di Pa |
ACTIVE_NOT_RECRUITING
|
| Italy | Palermo Ospedale Villa Sofia-Cervello |
ACTIVE_NOT_RECRUITING
|
| Italy | Pavia Fondazione IRCCS Policlinico San Matteo |
ACTIVE_NOT_RECRUITING
|
| Italy | Roma Università di Roma La Sapienza |
COMPLETED
|
| Italy | Roma Fondazione Policlinico Universitario A Gemelli IRCCS |
ACTIVE_NOT_RECRUITING
|
| Italy | San Giovanni Rotondo IRCCS Ospedale Casa Sollievo della Sofferenza |
COMPLETED
|
| Italy | Tricase Ospedale Cardinale G. Panico |
COMPLETED
|
| Netherlands | Amsterdam VU Medisch Centrum |
COMPLETED
|
| Netherlands | Groningen UMCG |
COMPLETED
|
| Spain | Barcelona Inst. Cat. Doncologia-H Duran I Reynals |
COMPLETED
|
| Spain | Gijón Hosp. de Cabuenes |
ACTIVE_NOT_RECRUITING
|
| Spain | Jerez de la Frontera Hosp. de Jerez de La Frontera |
COMPLETED
|
| Spain | Leon Hosp. de Leon |
COMPLETED
|
| Spain | Madrid Hosp. Univ. Ramon Y Cajal |
COMPLETED
|
| Spain | Madrid Hosp. Univ. 12 de Octubre |
COMPLETED
|
| Spain | Palma Hosp. Univ. Son Espases |
ACTIVE_NOT_RECRUITING
|
| Spain | Pamplona Clinica Univ. de Navarra |
COMPLETED
|
| Spain | Salamanca Hosp Clinico Univ de Salamanca |
COMPLETED
|
| Spain | Santander Hosp. Univ. Marques de Valdecilla |
COMPLETED
|
| Spain | Santiago de Compostela Hosp. Clinico Univ. de Santiago |
COMPLETED
|
| Spain | Valladolid Hosp. Clinico Univ. de Valladolid |
COMPLETED
|
| United Kingdom | Bristol Southmead Hospital |
ACTIVE_NOT_RECRUITING
|
| United Kingdom | London University College Hospital |
COMPLETED
|
| United Kingdom | London Kings College Hospital |
COMPLETED
|
| United Kingdom | London St George's Hospital |
COMPLETED
|
| United Kingdom | Maidstone Maidstone Hospital |
COMPLETED
|
| United Kingdom | Nottingham Nottingham University Hospitals NHS Trust |
ACTIVE_NOT_RECRUITING
|
| United Kingdom | Surrey The Royal Marsden NHS Trust Sutton |
COMPLETED
|
50.87959, 4.70093
50.3279, 4.88059
50.63297, 3.05858
43.61092, 3.87723
47.21725, -1.55336
45.7009, 4.82511
43.60426, 1.44367
52.4426272, 13.3103368
51.05089, 13.73832
53.57532, 10.01534
51.68033, 7.82089
49.40768, 8.69079
50.93333, 6.95
51.33962, 12.37129
48.52266, 9.05222
49.79391, 9.95121
41.11148, 16.8554
44.49381, 11.33875
37.49223, 15.07041
44.40478, 8.94438
44.12775, 12.0626
45.40797, 11.88586
38.13205, 13.33561
45.19205, 9.15917
41.89193, 12.51133
41.89193, 12.51133
41.70643, 15.7277
39.93018, 18.35421
52.37403, 4.88969
53.21917, 6.56667
41.38879, 2.15899
43.53573, -5.66152
36.68645, -6.13606
42.60003, -5.57032
40.4165, -3.70256
40.4165, -3.70256
39.56939, 2.65024
42.81687, -1.64323
40.96882, -5.66388
43.46472, -3.80444
42.88052, -8.54569
41.65518, -4.72372
51.45523, -2.59665
51.50853, -0.12574
51.50853, -0.12574
51.50853, -0.12574
51.26667, 0.51667
52.9536, -1.15047
51.3434765, -0.1910896
Indicates 50+ sites in this region: click to zoom in.
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Indicates < 10 sites in this region: click to zoom in.
Corresponds to individual site.