A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide (MonumenTAL-6)
Last Updated February 22, 2025
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64407564MMY3009
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 33 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to compare the effectiveness of either talquetamab plus pomalidomide (Tal-P) or talquetamab plus teclistamab (Tal-Tec) with elotuzumab, pomalidomide, and dexamethasone (EPd) or pomalidomide, bortezomib, and dexamethasone (PVd).
CONDITIONS
- Relapsed or Refractory Multiple Myeloma
ELIGIBILITY
Inclusion Criteria:
* Documented multiple myeloma as defined by the criteria below: (a) multiple myeloma diagnosis according to the international myeloma working group (IMWG) diagnostic criteria (b) measurable disease at screening as assessed by central laboratory, defined by any of
DETAILS
LOCATIONS
Locations in:
United States, Argentina, Australia, Austria, Belgium, Brazil, Canada, China, Czechia, Denmark, France, Germany, Greece, Hungary, India, Israel, Italy, Japan, South Korea, Netherlands, Poland, Saudi Arabia, Spain, Sweden, Türkiye, United Kingdom
| Country (26) | City or Province (163) | Status |
| United States | New Haven Yale University School Of Medicine |
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| United States | Saint Paul Regions Hospital |
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| United States | Cleveland Cleveland Clinic |
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| United States | Pittsburgh West Penn Hospital |
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| United States | Pittsburgh University Of Pittsburgh Medical Center (UPMC) Hillman Cancer Center |
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| Argentina | Buenos Aires Fundaleu |
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| Argentina | Buenos Aires Hospital Aleman |
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| Argentina | Ciudad Autonoma de Buenos Aires Hospital Britanico de Buenos Aires |
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| Australia | Adelaide Royal Adelaide Hospital |
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| Australia | Box Hill Box Hill Hospital |
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| Australia | Darlinghurst St Vincents Hospital |
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| Australia | Fitzroy St Vincents Hospital Melbourne |
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| Australia | Southport Gold Coast University Hospital |
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| Australia | West Perth Perth Blood Institute |
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| Australia | Wollongong Wollongong Hospital |
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| Austria | Salzburg LKH - Universitätsklinikum der PMU Salzburg |
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| Belgium | Charleroi Grand Hopital de Charleroi, site Notre Dame |
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| Belgium | Genk Ziekenhuis Oost-Limburg |
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| Belgium | Gent Ghent University Hospital |
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| Belgium | Sint-Niklaas AZ Nikolaas - Campus Sint-Niklaas Moerland |
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| Brazil | Belo Horizonte Cetus Oncologia |
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| Brazil | Brasilia DF Star |
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| Brazil | Caxias do Sul Fundacao Universidade de Caxias do Sul |
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| Brazil | Curitiba Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer |
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| Brazil | Porto Alegre Hospital de Clinicas de Porto Alegre |
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| Brazil | Recife Instituto D Or de Pesquisa e Ensino IDOR |
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| Brazil | Rio de Janeiro Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI) |
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| Brazil | Sao Jose do Rio Preto Hospital de Base da Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto |
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| Brazil | Sao Paulo Real e Benemerita Associacao Portuguesa de Beneficencia |
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| Brazil | Sao Paulo Fundacao Antonio Prudente A C Camargo Cancer Center |
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| Canada | Calgary Tom Baker Cancer Centre |
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| Canada | Hamilton Juravinski Cancer Centre |
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| Canada | Toronto University Health Network UHN Princess Margaret Cancer Centre |
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| Canada | Montreal CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont |
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| Canada | Saskatoon Saskatoon Cancer Centre |
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| China | Beijing Beijing Chaoyang Hospital |
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| China | Beijing Peking University First Hospital |
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| China | Beijing Peking University People s Hospital |
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| China | Changzhou Changzhou No 2 Peoples Hospital |
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| China | Guangzhou Sun Yat-Sen University Cancer Center |
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| China | Guangzhou Nanfang Hospital of Southern Medical Hospital |
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| China | Hangzhou First hospital affiliated of Zhejiang Medical university |
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| China | Hangzhou The Second Affiliated Hospital of Zhejiang University College of Medicine |
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| China | Jinan Qilu Hospital of Shandong University |
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| China | Nanchang The First Affiliated Hospital of NanChang University |
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| China | Shanghai Shanghai Fourth People s Hospital |
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| China | Shenyang Shengjing Hospital Of China Medical University |
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| China | Shenzhen Peking University Shenzhen Hospital |
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| China | Tianjin Tianjin Medical University Cancer Institute and Hospital |
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| China | Wenzhou The First Affiliated Hospital of Wenzhou Medical University |
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| China | Wuhan Tongji Hospital, Tongji Medical College of HUST |
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| Czechia | Brno - Bohunice Fakultni nemocnice Brno |
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| Czechia | Hradec Kralove Fakultni nemocnice Hradec Kralove |
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| Czechia | Olomouc University Hospital Olomouc |
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| Czechia | Ostrava Fakultni Nemocnice Ostrava |
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| Denmark | Aarhus Aarhus University Hospital |
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| Denmark | Odense C Odense University Hospital |
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| Denmark | Vejle Vejle Hospital |
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| France | Lille Hopital Claude Huriez |
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| France | Limoges CHU de Limoges Hopital Dupuytren |
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| France | Marseille Institut Paoli Calmettes |
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| France | Nantes CHU Nantes |
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| France | Paris Hopital Saint Louis |
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| France | Pessac Cedex CHU de Bordeaux - Hospital Haut-Leveque |
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| France | Pierre-Benite CHU Lyon Sud |
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| France | Strasbourg Institut de Cancerologie Strasbourg Europe ICANS |
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| France | Toulouse Cedex 9 Institut Universitaire du Cancer Toulouse Oncopole |
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| France | TOURS Cedex 01 CHRU Tours Hopital Bretonneau |
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| Germany | Augsburg Klinikum Augsburg |
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| Germany | Halle (Saale) Universitaetsklinikum Halle Saale |
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| Germany | Heidelberg Universitaetsklinikum Heidelberg |
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| Germany | Magdeburg Universitaetsklinikum Magdeburg A.oe.R |
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| Germany | München Klinikum rechts der Isar der TU Muenchen |
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| Germany | Tuebingen Universitaetsklinikum Tuebingen |
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| Germany | Würzburg Universitaetsklinikum Wuerzburg |
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| Greece | Athens 251 Airforces Hospital |
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| Greece | Athens Alexandra General Hospital of Athens |
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| Greece | Thessaloniki Anticancer Hospital of Thessaloniki Theageneio |
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| Hungary | Budapest Semmelweis Egyetem, Belgyogyaszati es Hematologiai Klinika |
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| Hungary | Pecs Pecsi Tudomanyegyetem Klinikai Kozpont |
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| India | Gurgaon Fortis Memorial Research Institute |
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| India | Pune Deenanath Mangeshkar Hospital and Research Centre |
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| Israel | Be'er Ya'akov Shamir Medical Center (Assaf Harofeh) |
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| Israel | Haifa Carmel Medical Center |
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| Israel | Petah-Tikva Rabin Medical center - Petah-Tikva |
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| Israel | Ramat Gan Sheba Medical Center |
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| Israel | Tel Aviv-Yafo Tel Aviv Sourasky Medical Center |
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| Italy | Alessandria Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria |
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| Italy | Brindisi oncologia medica - Oncology |
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| Italy | Catania ARNAS Garibaldi P O Nesima |
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| Italy | Genova Ospedale Policlinico San Martino IRCCS |
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| Italy | Legnano Asst Ovest Milanese - Ospedale Di Legnano |
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| Italy | Milano Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano |
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| Italy | Milano IRCCS Ospedale San Raffaele |
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| Italy | Pavia Fondazione IRCCS Policlinico San Matteo |
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| Italy | Pescara Presidio Ospedaliero Pescara |
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| Italy | Ravenna Ospedale S. Maria Delle Croci |
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| Italy | Torino Oncologia Medica-Città Della Salute E Della Scienza Di Torino |
RECRUITING
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| Italy | Verona Azienda Ospedaliera Universitaria Integrata Verona |
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| Japan | Bunkyo Ku Juntendo University Hospital |
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| Japan | Fukuoka Fukuoka University Hospital |
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| Japan | Kanazawa Kanazawa University Hospital |
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| Japan | Kyoto University Hospital Kyoto Prefectural University of Medicine |
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| Japan | Nagasaki National Hospital Organization Nagasaki Medical Center |
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| Japan | Narita Japanese Red Cross Narita Hospital |
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| Japan | Niigata Niigata Cancer Center Hospital |
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| Japan | Nishinomiya-shi Hyogo Medical University Hospital |
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| Japan | Osaka Japanese Red Cross Osaka Hospital |
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| Japan | Sapporo Sapporo City General Hospital |
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| Japan | Shibuya-ku Japanese Red Cross Medical Center |
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| Japan | Shiwa-gun Iwate Medical University Hospital |
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| Japan | Suita-City Osaka University Hospital |
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| Japan | Sunto-gun Shizuoka Cancer Center |
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| Japan | Tokyo The Cancer Institute Hospital of JFCR |
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| Japan | Tottori Tottori University Hospital |
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| Japan | Tsukuba University of Tsukuba Hospital |
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| Japan | Yokohama City Kanagawa Cancer Center |
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| South Korea | Busan Dong-A University Hospital |
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| South Korea | Busan Pusan National University Hospital |
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| South Korea | Jeollanam-do Chonnam National University Hwasun Hospital |
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| South Korea | Seoul Seoul National University Hospital |
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| South Korea | Seoul Samsung Medical Center |
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| South Korea | Seoul The Catholic University of Korea Seoul St Mary s Hospital |
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| South Korea | Ulsan Ulsan University Hospital |
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| Netherlands | Almere Flevoziekenhuis |
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| Netherlands | Den Haag Haga ziekenhuis |
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| Netherlands | Eindhoven Catharinaziekenhuis |
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| Netherlands | Nieuwegein St. Antonius Ziekenhuis Nieuwegein |
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| Netherlands | Zwolle Isala Kliniek |
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| Poland | Biala Podlaska Wojewodzki Szpital Specjalistyczny |
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| Poland | Brzozow Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza |
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| Poland | Kielce Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach |
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| Poland | Lublin Centrum Onkologii Ziemii Lubelskiej |
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| Poland | Szczecin Uniwersytecki Szpital Kliniczny Nr 1 PUM im prof Tadeusza Sokolowskiego w Szczecinie |
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| Poland | Wroclaw Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu |
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| Saudi Arabia | Riyadh King Faisal Specialist Hospital & Research Center |
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| Saudi Arabia | Riyadh King Fahad Medical City |
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| Spain | Asturias Hosp. de Cabuenes |
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| Spain | Barcelona Hosp Univ Vall D Hebron |
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| Spain | Burgos Hosp. Univ. de Burgos |
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| Spain | Cáceres Hosp. San Pedro de Alcantara |
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| Spain | Granada Hosp. Univ. Virgen de Las Nieves |
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| Spain | Lugo Hosp. Univ. Lucus Augusti |
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| Spain | Madrid Hosp. Univ. La Paz |
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| Spain | Palma de Mallorca Hosp. Univ. Son Espases |
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| Spain | Pamplona Clinica Univ. de Navarra |
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| Spain | Pamplona Complejo Hosp de Navarra - Hosp de Navarra |
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| Spain | Salamanca Hosp Clinico Univ de Salamanca |
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| Spain | San Sebastian Hosp. Univ. Donostia |
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| Spain | Santander Hosp. Univ. Marques de Valdecilla |
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| Spain | Santiago de Compostela Hosp. Clinico Univ. de Santiago |
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| Sweden | Lund Skanes universitetssjukhus |
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| Sweden | Uppsala Akademiska Sjukhuset |
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| Sweden | Varberg Varberg Hospital |
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| Türkiye | Ankara Ankara University Medical Faculty |
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| Türkiye | Ankara Liv Hospital Ankara |
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| Türkiye | Denizli Pamukkale University Medical Faculty |
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| Türkiye | Istanbul Medipol University Hospital |
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| Türkiye | Samsun Ondokuz Mayis University |
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| United Kingdom | Cardiff University Hospital of Wales |
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| United Kingdom | Dundee Ninewells Hospital |
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| United Kingdom | Plymouth University Hospitals Plymouth NHS Trust |
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| United Kingdom | Portsmouth Queen Alexandra Hospital |
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Geo Locations
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