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A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer

Last Updated   May 14, 2025

Want to learn how to participate in this trial?

86974680NSC1001

OVERVIEW

  • Sexes Eligible for Study
    all
  • Age
    18+ years
  • Phase
    phase 1
  • Sites
    10 Sites
  • Status
    Recruiting

SUMMARY

The purpose of this study is to determine a safe and tolerable dose(s) of JNJ-86974680 for further research in combination with cetrelimab and radiation therapy.

CONDITIONS

  • Carcinoma, Non-Small-Cell Lung

ELIGIBILITY


Inclusion Criteria:

* Individuals with histologically or cytologically confirmed stage IIIB-IV non-small cell lung cancer (NSCLC)
* Part 1: NSCLC with a known actionable genetic mutation (for example, epidermal growth factor receptor [EGFR], anaplastic lymphoma kinase [ALK], c-ros oncogene 1 [ROS1], v-raf murine sarcoma viral oncogene homolog B1 [BRAF]) must have received all approved targeted therapies and have progressed
* Part 2: No targetable mutations (for example, EGFR [epidermal growth factor receptor], ALK [anaplastic lymphoma kinase], ROS1[c-ros oncogene 1], and BRAF [B-Raf proto-oncogene, serine/threonine kinase])
* Part 1 and Cohort A of part 2: Must have been treated with (a) anti-programmed death protein 1 (anti-PD-1) or programmed cell death ligand 1 (PD-L1) therapy and (b) platinum-based chemotherapy
* For Cohort B of Part 2: Previously treated with anti-PD-1/PD-L1 therapy for metastatic disease as the prior line of therapy
* For Cohort C of Part 2: Treatment naïve
* Adequate organ function


Exclusion Criteria:

* Active central nervous system (CNS) disease involvement
* Active autoimmune disease
* Active infection
* History of solid organ or hematologic stem cell transplantation


Inclusion Criteria:

* Individuals with histologically or cytologically confirmed stage IIIB-IV non-small cell lung cancer (NSCLC)
* Part 1: NSCLC with a known actionable genetic mutation (for example, epidermal growth factor receptor [EGFR], anaplastic lymphoma kinase [ALK], c-ro

More...

DETAILS

LOCATIONS

Locations in:
United States, Germany, South Korea, Spain
Country (4) City or Province (10) Status
United States Buffalo Roswell Park Comprehensive Cancer Center
RECRUITING
United States New York Herbert Irving Comprehensive Cancer Center Columbia University Medical Center
RECRUITING
United States Philadelphia Thomas Jefferson University
RECRUITING
United States Fairfax Next Virginia
RECRUITING
Germany Berlin Charite Research Organisation GmbH
RECRUITING
Germany Giessen Universitaetsklinikum Giessen und Marburg GmbH
RECRUITING
South Korea Seoul Severance Hospital Yonsei University Health System
RECRUITING
South Korea Seoul Samsung Medical Center
RECRUITING
Spain Barcelona Hosp. Univ. Quiron Dexeus
RECRUITING
Spain Barcelona Hosp Univ Vall D Hebron
RECRUITING
Show More
Geo Locations

42.88645, -78.87837

40.71427, -74.00597

39.95233, -75.16379

38.84622, -77.30637

52.52437, 13.41053

50.58727, 8.67554

37.566, 126.9784

37.566, 126.9784

41.38879, 2.15899

41.38879, 2.15899

x
50

Indicates 50+ sites in this region: click to zoom in.

10

Indicates 10+ sites in this region: click to zoom in.

5

Indicates < 10 sites in this region: click to zoom in.

Corresponds to individual site.

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