A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

Last Updated   August 30, 2024

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88549968MPN1001

OVERVIEW

  • Sexes Eligible for Study
    all
  • Age
    18+ years
  • Phase
    phase 1
    1
  • Sites
    14 Sites
  • Status
     Recruiting

SUMMARY

The purpose of this study is to characterize safety and to determine the Recommended Phase 2 Dose (RP2D[s]) and optimal dosing schedule(s) of JNJ-88549968, in part 1 (Dose Escalation); to characterize the safety of JNJ- 88549968 at RP2D(s), in part 2 (Cohort Expansion).

CONDITIONS

  • Myeloproliferative Disorders
  • Essential Thrombocythemia
  • Cancer
  • Primary Myelofibrosis

ELIGIBILITY


Inclusion Criteria:

* Be greater than or equal to (>=) 18 years of age (or the legal age of majority in the jurisdiction in which the study is taking place, whichever the greater) at the time of informed consent
* Positive for a calreticulin (CALR) driver mutation of essential th

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DETAILS

LOCATIONS

Locations in:
United States, Canada, France, Germany, Spain, United Kingdom
Country (6) City or Province (14) Status
United States Duarte City of Hope
RECRUITING
United States Ann Arbor University of Michigan
RECRUITING
United States Charlotte Levine Cancer Institute
RECRUITING
United States Philadelphia University of Pennsylvania
RECRUITING
United States Nashville Sarah Cannon Cancer Institute
RECRUITING
United States Houston MD Anderson Cancer Center
RECRUITING
Canada Toronto University Health Network UHN Princess Margaret Cancer Centre
RECRUITING
France Paris Hopital Saint Louis
RECRUITING
France Pierre Benite Cedex CH LYON SUD - Hematology
RECRUITING
Germany Aachen Universitaetsklinikum der RWTH Aachen
RECRUITING
Spain Badalona Hosp. Univ. Germans Trias I Pujol
RECRUITING
Spain Valencia Hosp. Clinico Univ. de Valencia
RECRUITING
United Kingdom London University College London Hospitals Nhs Foundation Trust
RECRUITING
United Kingdom Oxford Churchill Hospital
RECRUITING
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Geo Locations

34.13945, -117.97729

42.27756, -83.74088

35.22709, -80.84313

39.95233, -75.16379

36.16589, -86.78444

29.76328, -95.36327

43.70011, -79.4163

48.85341, 2.3488

45.7009, 4.82511

50.77664, 6.08342

41.45004, 2.24741

39.46975, -0.37739

51.50853, -0.12574

51.75222, -1.25596

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50

Indicates 50+ sites in this region: click to zoom in.

10

Indicates 10+ sites in this region: click to zoom in.

5

Indicates < 10 sites in this region: click to zoom in.

Corresponds to individual site.

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