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My Saved Trials

A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder (Moonlight-1)

Last Updated   May 21, 2025

Want to learn how to participate in this trial?

89495120MDD2001

OVERVIEW

  • Sexes Eligible for Study
    all
  • Age
    18+ years
  • Phase
    phase 2
  • Sites
    24 Sites
  • Status
    Recruiting

SUMMARY

The purpose of this study is to evaluate how well JNJ-89495120 works (anti-depressant effects) and how well it is tolerated as compared to placebo on reducing the symptoms of depression in participants with major depressive disorder (MDD).

CONDITIONS

  • Depressive Disorder, Major

ELIGIBILITY


Inclusion Criteria:

* Primary psychiatric diagnosis of recurrent major depressive disorder, without psychotic features, based on clinical assessment using diagnostic and statistical manual of mental disorders (DSM)-5 criteria and confirmed with the mini international neuropsychiatric interview (MINI)
* Participant had to have at least one previous major depressive disorder (MDD) episode prior to their current episode
* Were first diagnosed with depression before the age of 55
* Are in a current episode of depression: Episode length must be at least 2 months but not longer than 24 months
* Have taken 0, 1, or 2 treatments for depression in your current episode
* Body mass index (BMI) within the range 18 to 35 kilograms per square meter (kg/m^2) at screening


Exclusion Criteria:

* Treatment with vagus nerve stimulation (VNS), electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), or ketamine/esketamine within the current or past major depressive episodes
* Current or past DSM-5 diagnosis of bipolar disorder, psychotic disorders, borderline personality disorder, antisocial personality disorder, or current obsessive-compulsive disorder
* Post-traumatic stress disorder within the past three years of screening
* Dementia, any dementing disease, intellectual disability, or neurocognitive disorder
* History of Alcohol and Substance use disorders within 6 months of screening, with the exclusion of nicotine, caffeine, and mild cannabis use disorder, according to the MINI and Clinical Assessment
* Known allergies, hypersensitivity, or intolerance to JNJ-89495120 or its excipients


Inclusion Criteria:

* Primary psychiatric diagnosis of recurrent major depressive disorder, without psychotic features, based on clinical assessment using diagnostic and statistical manual of mental disorders (DSM)-5 criteria and confirmed with the mini international neuropsychiatri

More...

DETAILS

LOCATIONS

Locations in:
United States
Country (1) City or Province (24) Status
United States Redlands Anderson Clinical Research
RECRUITING
United States Temecula Viking Clinical Research Ltd
RECRUITING
United States Walnut Creek Sunwise Clinical Research
RECRUITING
United States Pembroke Pines Best Choice Medical and Research Service
RECRUITING
United States Atlanta Synexus Clinical Research US Inc
RECRUITING
United States New Orleans DelRicht Research
RECRUITING
United States North Charleston Coastal Carolina Research Center
RECRUITING
United States Bellflower CI Trials
RECRUITING
United States San Diego Artemis Institute for Clinical Research
RECRUITING
United States Homestead Advanced Research Institute of Miami
RECRUITING
United States Miami Wellness Research Center
RECRUITING
United States Gaithersburg CBH Health
RECRUITING
United States Sherman Revival Research Institute LLC
RECRUITING
United States Chandler Chandler Clinical Trials
RECRUITING
United States Phoenix IMA Clinical Research PC
RECRUITING
United States Garden Grove National Institute Of Clinical Research
RECRUITING
United States Santa Ana Syrentis Clinical Research
RECRUITING
United States Fort Myers Gulfcoast Medical Research Center
SUSPENDED
United States Hollywood The Medici Medical Research
RECRUITING
United States Tampa Interventional Psychiatry of Tampa Bay
RECRUITING
United States Brooklyn Integrative Clinical Trials LLC
RECRUITING
United States Cincinnati University of Cincinnati
RECRUITING
United States Clinton Alpine Research Organization
RECRUITING
United States Everett Core Clinical Research
RECRUITING
Show More
Geo Locations

34.05557, -117.18254

33.49364, -117.14836

37.90631, -122.06496

26.00315, -80.22394

33.749, -84.38798

29.95465, -90.07507

32.85462, -79.97481

33.88168, -118.11701

32.71533, -117.15726

25.46872, -80.47756

25.77427, -80.19366

39.14344, -77.20137

33.63566, -96.60888

33.30616, -111.84125

33.44838, -112.07404

33.77391, -117.94145

33.74557, -117.86783

26.62168, -81.84059

26.0112, -80.14949

27.94752, -82.45843

40.6501, -73.94958

39.12713, -84.51435

41.13967, -112.0505

47.97898, -122.20208

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