Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension (UNISUS)

Last Updated   February 28, 2024 - 20:08

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OVERVIEW

  • Gender
    all
  • Age
    18+ years
  • Phase
    phase 3
    The drug or treatment is given to large groups of people to confirm its effectiveness, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
  • Sites
    273 sites
  • Status
    Recruiting

SUMMARY

The purpose of this study is to demonstrate superiority of macitentan 75 milligrams (mg) in prolonging the time to the first clinical events committee (CEC)-adjudicated morbidity or mortality (M/M) event in participants with symptomatic pulmonary arterial hypertension (PAH) compared to macitentan 10 mg.

CONDITIONS

  • Pulmonary Arterial Hypertension

ELIGIBILITY

Inclusion Criteria:

* Target population: greater than or equal to (>=) 18 (or the legal age of consent in the jurisdiction in which the study is taking place) years of age

* Target population: Symptomatic Pulmonary Arterial Hypertension (PAH) in World Health Organization Functional Class (WHO FC) II, III, or IV

* Target population: PAH subtype falling in one of the below classifications: Idiopathic; Heritable; Drug- or toxin-induced; Related to: Connective tissue disease, HIV infection, Portal hypertension, and Congenital heart disease with small/coincidental cardiac defect with systemic-to-pulmonary shunt (for example atrial septal defect, ventricular septal defect, patent ductus arteriosus, atrioventricular septal defect) which does not account for the elevated pulmonary vascular resistance (PVR) or persistent PAH documented by an Right heart catheterization (RHC) >= 1 year after simple systemic-to pulmonary shunt repair

* PAH diagnosis confirmed by hemodynamic evaluation at rest at any time prior to screening: Mean pulmonary artery pressure (mPAP) greater than (>) 20 millimeters of mercury (mm Hg), and; Pulmonary artery wedge pressure (PAWP) or left ventricular end diastolic pressure (LVEDP) less than or equal to (<=) 15 mm Hg, and PVR >= 3 Wood Units (that is, >= 240 dyn*sec/cm^5)

* Able to perform the 6-minute walking test (6MWT) with a minimum distance of 50 meters (m) and maximum distance of 440m at screening. Participants able to walk more than 440m at screening are eligible if they are in WHO FC III or IV and n-terminal prohormone of brain natriuretic peptide or n-terminal pro B-type natriuretic peptide (NT-proBNP) level is >=300 nanograms per liter (ng/L) at screening, based on central laboratory results

Exclusion Criteria:

* Known presence of three or more of the following risk factors for heart failure with preserved ejection fraction at screening, based on records that confirm documented medical history: Body mass index (BMI) > 30 kilograms per meter square (kg/m^2), Diabetes mellitus of any type, Essential hypertension (even if well controlled); Coronary artery disease, that is, any of the following: history of stable angina, or known more than 50 percent (%) stenosis in a coronary artery, or history of myocardial infarction, or history of or planned coronary artery bypass grafting and/or coronary artery stenting

* Presence of moderate or severe obstructive lung disease (forced expiratory volume in 1 second [FEV1] / forced vital capacity [FVC] < 70%; and FEV1 < 60% of predicted after bronchodilator administration) ) in participants with a known or suspected history of significant lung disease as documented by a spirometry test performed within 1 year prior to screening

* Known moderate to severe hepatic impairment, defined as Child-Pugh Class B or C, based on records that confirm documented medical history

* Serum aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) > 1.5*upper limit of normal (ULN) at screening

* Hemoglobin < 100 gram per liter (g/L) (< 10 gram per deciliter [g/dL]) at screening

DETAILS

LOCATIONS

Locations in:
Vietnam, United States, United Kingdom, Ukraine, Turkey, Thailand, Taiwan, Sweden, Spain, South Korea, South Africa, Slovakia, Singapore, Serbia, Saudi Arabia, Russia, Portugal, Poland, Norway, Netherlands, Mexico, Malaysia, Japan, Italy, Israel, India, Hungary, Greece, Germany, France, Denmark, Czechia, Colombia, China, Canada, Bulgaria, Brazil, Belgium, Belarus, Austria, Australia, Argentina
Country (42) City or Province (273) Status
Vietnam Hanoi Hanoi Medical University Hospital
RECRUITING
Vietnam Ho Chi Minh Cho Ray Hospital
RECRUITING
Vietnam Ho Chi Minh Tam Anh Hospital
RECRUITING
Vietnam Ho Chi Minh Tam Duc Heart Hospital
RECRUITING
Vietnam Ho Chi Minh University Medical Center Ho Chi Minh city
RECRUITING
United States Anderson, SC AnMed Health
RECRUITING
United States Ann Arbor, MI University of Michigan
RECRUITING
United States Atlanta, GA Northside Hospital
RECRUITING
United States Austell, GA Piedmont Healthcare
RECRUITING
United States Burlington, VT The Robert Larner, M.D. College of Medicine at The University of Vermont
RECRUITING
United States Cincinnati, OH Lindner Clinical Trial Center/Christ Hospital
RECRUITING
United States Dallas, TX UT Southwestern Medical Center
RECRUITING
United States Denver, CO National Jewish Health
RECRUITING
United States Durham, NC Duke
RECRUITING
United States Houston, TX Baylor College of Medicine (BCM) - Baylor Heart Clinic
RECRUITING
United States Indianapolis, IN Indiana University
COMPLETED
United States Indianapolis, IN St. Vincent Medical Group, Inc.
RECRUITING
United States Iowa City, IA University Of Iowa - Hospitals & Clinics
RECRUITING
United States La Jolla, CA Scripps Memorial Hospital
RECRUITING
United States Los Angeles, CA USC Keck
RECRUITING
United States Louisville, KY Norton Pulmonary Specialists
RECRUITING
United States Madison, WI University of Wisconsin Hospital and Clinics
RECRUITING
United States Milwaukee, WI Medical College Of Wisconsin
RECRUITING
United States Mineola, NY Winthrop University Hospital
COMPLETED
United States New Orleans, LA Louisiana State University
COMPLETED
United States New York, NY Columbia University
RECRUITING
United States New York, NY Mount Sinai
RECRUITING
United States Oak Lawn, IL Advocate Christ Medical Center
COMPLETED
United States Oklahoma City, OK Integris Baptist Office
RECRUITING
United States Omaha, NE University of Nebraska Medical Center
RECRUITING
United States Philadelphia, PA University of Pennsylvania
RECRUITING
United States Phoenix, AZ Arizona Pulmonary Specialists, Ltd
RECRUITING
United States Phoenix, AZ Mayo Clinic
RECRUITING
United States Pittsburgh, PA Allegheny General Hospital of Research
RECRUITING
United States Plano, TX Baylor Scott White - Plano
RECRUITING
United States Portland, OR Oregon Health & Science University
RECRUITING
United States Portland, OR Oregon Pulmonary Clinic
RECRUITING
United States Portland, OR The Oregon Clinic
RECRUITING
United States Reno, NV Reno Heart Institute
RECRUITING
United States Saint Louis, MO Saint Louis University Academic Pavillion
RECRUITING
United States Saint Louis, MO Washington University School of Medicine
RECRUITING
United States San Antonio, TX San Antonio Methodist/TX Transplant Physicians Group
RECRUITING
United States Santa Barbara, CA Jeffrey S. Sager, MD Medical Corporation
RECRUITING
United States Stony Brook, NY Stony Brook University Medical Center
COMPLETED
United States Torrance, CA Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
RECRUITING
United States Troy, MI Troy Beaumont
RECRUITING
United States Weston, FL Cleveland Clinic
RECRUITING
United States Wynnewood, PA Lankenau Medical Center
COMPLETED
United Kingdom London Royal Free Hospital
RECRUITING
United Kingdom Newcastle Upon Tyne Freeman Hospital
RECRUITING
United Kingdom Sheffield, SYK Sheffield Teaching Hospitals NHS Foundation Trust Royal Hallamshire Hospital
RECRUITING
Ukraine Cherkassy CNE 'Cherkasy Regional Cardiological Center of Cherkasy Regional Council'
SUSPENDED
Ukraine Cherkasy Communal Noncommercial Enterprise Cherkasy Regional Hospital of Cherkasy Regional Council
SUSPENDED
Ukraine Dnipro MI 'Dnipropetrovsk Regional Clinical Center of Cardiology and Cardiac Surgery'
SUSPENDED
Ukraine Kharkiv CNE' City Clinical Hospital #8' of Kharkiv City Council
COMPLETED
Ukraine Kyiv SI National Scientific Center Institute of Cardiology of M.D. Strazhesko of NAMS of Ukraine
SUSPENDED
Ukraine Kyiv State Institute Of Phthisiology And Pulmonology N.A. F.G. Yanovskiy Of Ams Ukraine
SUSPENDED
Ukraine Lviv Communal Noncommercial Enterprise of Lviv Regional Council 'Lviv Regional Clinical Hospital'
SUSPENDED
Ukraine Ternopil Municipal Non-commercial Enterprise Ternopil University Hospital of Ternopil Regional Council
SUSPENDED
Turkey Adana Adana City Hospital
RECRUITING
Turkey Adana Cukurova University Medical Faculty
COMPLETED
Turkey Ankara Ankara Bilkent Sehir Hastanesi
RECRUITING
Turkey Ankara Ankara Etlik Speciality Hospital
RECRUITING
Turkey Ankara Gazi University Medical Faculty
RECRUITING
Turkey Ankara Hacettepe University Medical Faculty
RECRUITING
Turkey Antalya Akdeniz University Medical Faculty
RECRUITING
Turkey Bursa Bursa Yuksek Ihtisas Training and Research Hospital
RECRUITING
Turkey Denizli Pamukkale University Medical Faculty
RECRUITING
Turkey Istanbul Marmara University Medical Faculty
RECRUITING
Turkey Istanbul Siyami Ersek Training and Research Hospital
RECRUITING
Turkey Izmir Dokuz Eylul University Medical Faculty
RECRUITING
Turkey Izmir Ege University Medical Faculty
RECRUITING
Turkey Izmir Tepecik Training and Research Hospital
SUSPENDED
Turkey Kartal Istanbul Kartal Kosuyolu Yuksek Ihtisas Egitim Ve Arastirma Hastanesi
RECRUITING
Turkey Mersin Mersin University Medical Faculty
RECRUITING
Thailand Bangkok, 10 Phramongkutklao Hospital and Medical College
COMPLETED
Thailand Bangkok, 10 Ramathibodi Hospital, Mahidol University
RECRUITING
Thailand Bangkok, 10 Siriraj Hospital Mahidol University
RECRUITING
Thailand Chiang Mai, 50 Maharaj Nakorn Chiang Mai hospital - Faculty of Medicine
RECRUITING
Thailand Khon Kaen, 40 Srinagarind Hospital, Khon Kaen University
RECRUITING
Thailand Songkhla, 90 Songklanagarind hospital
RECRUITING
Taiwan Tainan National Cheng Kung University Hospital
RECRUITING
Taiwan Taipei Mackay Memorial Hospital
RECRUITING
Taiwan Taipei National Taiwan University Hospital
RECRUITING
Taiwan Taipei Taipei Veterans General Hospital
RECRUITING
Sweden Goteborg Sahlgrenska Universitetsjukhuset
RECRUITING
Sweden Lund Skanes universitetssjukhus
RECRUITING
Spain Barcelona, BA Hosp. Del Mar
COMPLETED
Spain Barcelona, BA Hosp. Univ. Vall D Hebron
COMPLETED
Spain Madrid, MD Hosp. Univ. 12 de Octubre
RECRUITING
Spain Madrid, MD Hosp. Univ. La Paz
RECRUITING
Spain Madrid, MD Hosp. Univ. Pta. de Hierro Majadahonda
RECRUITING
Spain Malaga Hosp. Costa Del Sol
RECRUITING
Spain Salamanca, SL Hosp. Clinico Univ. de Salamanca
RECRUITING
South Korea Seoul Asan Medical Center
RECRUITING
South Korea Seoul Samsung Medical Center
RECRUITING
South Korea Seoul Seoul National University Hospital
RECRUITING
South Korea Seoul Severance Hospital Yonsei University Health System
RECRUITING
South Africa Johannesburg, GT Milpark Hospital
RECRUITING
South Africa Lenasia, GT Dr Kalla
RECRUITING
Slovakia Bratislava Narodny ustav srdcovych a cievnych chorob
RECRUITING
Slovakia Kosice The Eastern Slovakia Institute of Cardiovascular Diseases
RECRUITING
Singapore Singapore National Heart Centre (NHC) Singapore
RECRUITING
Singapore Singapore National University Heart Centre, Singapore
RECRUITING
Serbia Belgrade University Clinical Center of Serbia
RECRUITING
Serbia Sremska Kamenica Institute for Pulmonary Disease of Vojvodina
RECRUITING
Saudi Arabia Riyadh King Fahad Medical City
RECRUITING
Saudi Arabia Riyadh King Faisal Specialist Hospital & Research Center
RECRUITING
Russia Barnaul Altay Regional Cardiological Dispensary
SUSPENDED
Russia Chelyabinsk Chelyabinsk Regional Clinical Hospital
TERMINATED
Russia Kazan State Autonomous HealthCare Institution 'Interregional Clinical Diagnostic Center'
SUSPENDED
Russia Kemerovo Scientific and Research Institution of Cardiovascular Diseases Complex Problems
TERMINATED
Russia Moscow Moscow City Clinical Hospital No.51
COMPLETED
Russia Moscow National Medical Research Center of Cardiology of MoH of Russian Federation
TERMINATED
Russia Saint-Petersburg National medical Research Center n.a. V.A.Almazov of MoH of Russian Federation
SUSPENDED
Russia Samara Samara Regional Clinical Cardiological Dispensary
TERMINATED
Russia Tumen State Autonomous Healthcare Institution of Tyumen Region 'Scientific and Practical Medical Center'
COMPLETED
Russia Volgograd Volgograd Regional Clinical Cardiology Center
SUSPENDED
Portugal Coimbra Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra
RECRUITING
Portugal Lisboa Centro Hospitalar Lisboa Norte EPE - Hospital Pulido Valente
RECRUITING
Portugal Lisbon Hospital De Santa Marta
RECRUITING
Poland Bialystok Uniwersytecki Szpital Kliniczny w Białymstoku
RECRUITING
Poland Bydgoszcz Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy, Klinika Kardiologii
COMPLETED
Poland Gdansk Uniwersyteckie Centrum Kliniczne
RECRUITING
Poland Katowice SPSK nr 7 SUM w Katowicach Gornoslaskie Centrum Medyczne im. Prof. Leszka Gieca
RECRUITING
Poland Krakow Krakowski Szpital Specjalityczny im. Jana Pawla II, Oddzial Kliniczny Chorob Serca i Naczyn
RECRUITING
Poland Szczecin Samodzielny Publiczny Szpital Kliniczny nr 2 PUM
RECRUITING
Poland Warszawa Centralny Szpital Kliniczny MSWiA w Warszawie
RECRUITING
Poland Wroclaw Wojewodzki Szpital Specjalist, Osrodek Badawczo-Rozwojowy
COMPLETED
Norway Nordbyhagen Akershus Universitetssykehus
COMPLETED
Norway Oslo, OL Oslo University Hospital
COMPLETED
Netherlands Amsterdam VUMC Amsterdam
RECRUITING
Netherlands Nieuwegein, UT St. Antonius Ziekenhuis Nieuwegein
RECRUITING
Netherlands Nijmegen, GE Radboud Umcn
RECRUITING
Netherlands Rotterdam Erasmus MC
COMPLETED
Mexico Ciudad De México Instituto Nacional de Cardiologia Dr. Ignacio Chavez
RECRUITING
Mexico Guadalajara, JAL Consultorio Privado del Dr. Gabriel Arturo Ramos Lopez
RECRUITING
Mexico Mexico Operadora de Hospitales Angeles SA de CV Hospital Angeles Lomas
RECRUITING
Mexico Monterrey Hospital Universitario 'Dr. Jose Eleuterio Gonzalez'
RECRUITING
Mexico Monterrey Unidad de Investigacion Clinica en Medicina S.C. (UDICEM)
RECRUITING
Mexico Morelia Centro de Investigacion Clinica Chapultepec
RECRUITING
Malaysia George Town Hospital Pulau Pinang
RECRUITING
Malaysia Kajang, SL Hospital Serdang
RECRUITING
Malaysia Kota Samarahan, Kuching, SR Sarawak Heart Center
RECRUITING
Malaysia Kuala Lumpur Institut Jantung Negara (National Heart Institute)
RECRUITING
Japan Bunkyo, 13 The University of Tokyo Hospital
ACTIVE_NOT_RECRUITING
Japan Fukuoka Kyushu University Hospital
ACTIVE_NOT_RECRUITING
Japan Hiroshima Kure Kyosai Hospital
ACTIVE_NOT_RECRUITING
Japan Kagoshima City Kagoshima University Hospital
ACTIVE_NOT_RECRUITING
Japan Kanagawa, 14 St.Marianna University Hospital
ACTIVE_NOT_RECRUITING
Japan Kanazawa Kanazawa University Hospital
RECRUITING
Japan Kobe, 28 Kobe University Hospital
ACTIVE_NOT_RECRUITING
Japan Kurume Kurume University Hospital
ACTIVE_NOT_RECRUITING
Japan Kyoto University Hospital Kyoto Perfectural University of Medicine
ACTIVE_NOT_RECRUITING
Japan Kyoto, 26 Kyoto University Hospital
ACTIVE_NOT_RECRUITING
Japan Matsumoto Shinshu University Hospital
ACTIVE_NOT_RECRUITING
Japan Nagasaki-shi, 42 Nagasaki University Hospital
ACTIVE_NOT_RECRUITING
Japan Nagoya Nagoya City University Hospital
ACTIVE_NOT_RECRUITING
Japan Nagoya Nagoya University Hospital
ACTIVE_NOT_RECRUITING
Japan Niigata, 15 Niigata University Medical & Dental Hospital
ACTIVE_NOT_RECRUITING
Japan Okayama, 33 National Hospital Organization Okayama Medical Center
ACTIVE_NOT_RECRUITING
Japan Okayama, 33 Okayama University Hospital
RECRUITING
Japan Sapporo, 01 Sapporo Medical University Hospital
ACTIVE_NOT_RECRUITING
Japan Sapporo-shi, 01 Hokkaido University Hospital
ACTIVE_NOT_RECRUITING
Japan Suita-Shi, 27 National Cerebral and Cardiovascular Center
RECRUITING
Japan Tokyo, 13 Juntendo University Hospital
ACTIVE_NOT_RECRUITING
Japan Toyoake Fujita Health University Hospital
ACTIVE_NOT_RECRUITING
Japan Tsukuba-City, 08 University of Tsukuba Hospital
ACTIVE_NOT_RECRUITING
Italy Milano ASST Grande Ospedale Metropolitano Niguarda
RECRUITING
Italy Modena AOU Di Modena, Policlinico Di Modena
RECRUITING
Italy Nuoro Ospedale San Francesco
COMPLETED
Italy Pavia Fondazione IRCCS Policlinico San Matteo
RECRUITING
Italy Pisa Fondazione Toscana Gabriele Monasterio CNR
RECRUITING
Italy Roma Policlinico Gemelli Universita Cattolica
RECRUITING
Israel Haifa, H Carmel Medical Center
COMPLETED
Israel Jerusalem Shaare Zedek Medical Center
RECRUITING
Israel Rehovot Kaplan Medical Center
RECRUITING
Israel Tel-Hashomer The Chaim Sheba Medical Center
RECRUITING
Israel Zerifin Yitzhak Shamir Medical Center
COMPLETED
India Ahmedabad, GJ Cims Hospital
RECRUITING
India Ahmedabad, GJ NHL Medical College (SVP Hospital IMSR)
RECRUITING
India Bangalore, KA Narayana Hrudayalaya Limited
RECRUITING
India Chengalpetu, TN SRM Medical College Hospital & Research Centre
RECRUITING
India Coimbatore, TN Govindaswamy Kuppuswamy Naidu Memorial Hospital
RECRUITING
India Durgapur, WB HealthWorld Hospitals
RECRUITING
India Hyderbad Care Hospitals
RECRUITING
India Kolkata, WB Rabindranath Tagore International Institute of Cardiac Sciences
RECRUITING
India New Delhi, DL GB Pant Institute of Post Graduate Medical Education & Research
RECRUITING
India New Delhi, DL Sir Ganga Ram Hospital
RECRUITING
India Pondicherry Jawaharlal Institute of Postgraduate Medical Education and Research
RECRUITING
India Surat, GJ B.D. Mehta Mahavir Heart Institute
RECRUITING
Hungary Budapest Gottsegen György Országos Kardiológiai Intézet, Felnőtt kardiológiai osztály
RECRUITING
Hungary Budapest Semmelweis Egyetem,Pulmonológiai Klinika
RECRUITING
Hungary Pecs Pecsi Tudomanyegyetem Klinikai Kozpont
RECRUITING
Hungary Szeged Szegedi Tudományegyetem, Általános Orvostudományi Kar, Családorvosi Intézet és rendelő
RECRUITING
Greece Alexandroupoli University Hospital of Alexandroupolis
RECRUITING
Greece Athens Alexandra General Hospital of Athens
RECRUITING
Greece Larisa University Hospital Of Larissa
RECRUITING
Greece Thessaloniki Ahepa University General Hospital of Thessaloniki
RECRUITING
Germany Bad Oeynhausen Ruhr-Universität Bochum / Diabeteszentrum
COMPLETED
Germany Hannover Medizinische Hochschule Hannover
RECRUITING
Germany München Medizinische Klinik und Poliklinik V Klinikum Grosshadern der LMU
RECRUITING
Germany Regensburg Universitaetsklinikum Regensburg
RECRUITING
France Brest CHU de Brest - Hôpital de la Cavale Blanche
COMPLETED
France Caen Cedex Hôpital Côte de Nacre
RECRUITING
France Le Kremlin Bicêtre cedex Hopital Bicêtre - Aphp Hôpitaux Universitaires Paris-Sud
RECRUITING
France Lille Cedex CHRU de Lille - Hopital Claude Huriez
COMPLETED
France Marseille Cedex 20 Aphm - Hopital Nord
COMPLETED
France Nice Centre Hospitalier Universitaire - de Nice - Hopital Pasteur
RECRUITING
France St Priest en Jarez Cedex CHU Saint-Etienne - Hopital Nord
RECRUITING
France Toulouse Cedex 9 Hopital Larrey CHU de Toulouse
RECRUITING
Denmark Arhus Århus Universitetshospital, Skejby, Hjertemedicinsk Afdeling B
RECRUITING
Czechia Praha 2 General University Hospital II.department of Internal Medicine-cardiology and angiology
RECRUITING
Colombia Bogota Fundacion Neumologica Colombiana
RECRUITING
Colombia Bucaramanga - Piedecuesta - Valle De Menzuli, SAN Fundacion Cardiovascular de Colombia
RECRUITING
Colombia Cali, VDC Clínica Imbanaco S.A.S.
RECRUITING
Colombia Medellin, ANT Centro Cardiovascular Colombiano Clínica Santa María
RECRUITING
Colombia Soledad Hospital Universidad del Norte
RECRUITING
China Beijing, 11 Beijing Anzhen Hospital
RECRUITING
China Beijing, 11 Beijing Chaoyang Hospital
RECRUITING
China Beijing, 11 Peking Union Medical College Hospital
RECRUITING
China Changsha The Second Xiangya Hospital of Central South Hospital
RECRUITING
China Chengdu West China Hospital, Sichuan University
RECRUITING
China Chongqing, 97 The First Affiliated Hospital of Chongqing Medical University
RECRUITING
China Guangzhou The First Affiliated Hospital of Guangzhou Medical University
RECRUITING
China Shanghai, 31 Renji Hospital
RECRUITING
China Shanghai, 31 Shanghai Pulmonary Hospital
RECRUITING
China Shanghai, 31 Zhongshan Hospital,Fudan University
RECRUITING
China Shenyang Shengjing Hospital of China Medical University
RECRUITING
China Shenyang The General Hospital of Northern Theater Command
RECRUITING
China Tianjin, 12 Tianjin Medical University General Hospital
RECRUITING
China Xi'An The First Affiliated Hospital of Xian Jiaotong University
RECRUITING
Canada Hamilton, ON St. Joseph's Health Centre
RECRUITING
Canada Montreal, QC Jewish General Hospital
RECRUITING
Canada Ottawa, ON University of Ottawa Heart Institute
RECRUITING
Canada Toronto, ON University Health Network - Toronto General Hospital
RECRUITING
Bulgaria Sofia Multiprofile Hospital For Active Treatment National Cardiology Hospital, Ead
RECRUITING
Bulgaria Sofia University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD
RECRUITING
Brazil Belo Horizonte, MG Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa
RECRUITING
Brazil Belo Horizonte, MG Universidade Federal De Minas Gerais - Hospital das Clínicas
RECRUITING
Brazil Brasilia, DF Empresa Brasileira de Servicos Hospitalares-EBSERH-Hospital Universitario de Brasilia
RECRUITING
Brazil Campina Grande do Sul Sociedade Hospitalar Angelina Caron - Hospital Angelina Caron
RECRUITING
Brazil Curitiba, PR Ceti - Centro de Estudos Em Terapias Inovadoras
RECRUITING
Brazil Florianopolis, SC Ynova Pesquisa Clinica
RECRUITING
Brazil Goiania Universidade Federal de Goias - Hospital das Clinicas da UFG
RECRUITING
Brazil Porto Alegre, RS Hospital das Clinicas de Porto Alegre
RECRUITING
Brazil Porto Alegre, RS Uniao Brasileira de Educaçao e Assistencia-Hospital Sao Lucas da PUCRS
RECRUITING
Brazil Recife Instituto de Medicina Integral Professor Fernando Figueira
RECRUITING
Brazil Santo Andre, SP Fundacao do ABC - Centro Universitario FMABC
RECRUITING
Brazil Sao Paulo, SP Hospital Das Clinicas Da Faculdade De Medicina Da USP
RECRUITING
Brazil Sao Paulo, SP Secretaria de Estado da Saúde - Instituto Dante Pazzanese de Cardiologia
RECRUITING
Belgium Brussels, BRU ULB Hôpital Erasme
RECRUITING
Belgium Leuven UZ Leuven
RECRUITING
Belarus Minsk Minsk Regional Clinical Hospital
SUSPENDED
Belarus Minsk The Republican Scientific-Practical Center ''Cardiology''
SUSPENDED
Austria Graz LKH-Univ. Klinikum Graz
RECRUITING
Austria Linz Ordensklinikum Linz GmbH Elisabethinen
RECRUITING
Austria Vienna Medical University Vienna
RECRUITING
Australia Bedford Park, SA Flinders Medical Centre
RECRUITING
Australia Camperdown, NSW Royal Prince Alfred Hospital
RECRUITING
Australia Chermside, QLD The Prince Charles Hospital
RECRUITING
Australia Darlinghurst, NSW St Vincent's hospital
RECRUITING
Australia Hobart, TAS Royal Hobart Hospital
RECRUITING
Australia Murdoch, WA Fiona Stanley Hospital
RECRUITING
Australia Westmead, NSW Westmead Hospital
RECRUITING
Argentina Buenos Aires, B Sanatorio de la Trinidad Mitre
RECRUITING
Argentina C.a.b.a., B Sanatorio Guemes
RECRUITING
Argentina Caba, B Centro Médico Dra. De Salvo
RECRUITING
Argentina Caba, B Hospital Italiano de Buenos Aires
RECRUITING
Argentina Caba, B Sanatorio Ramon Cereijo
COMPLETED
Argentina Corrientes Instituto de Cardiologia de Corrientes
RECRUITING
Argentina Rosario Instituto Cardiovascular de Rosario
RECRUITING
Argentina Rosario Instituto Medico de La Fundacion Estudios Clinicos
RECRUITING
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