A Study of Niraparib in Combination with Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants with Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic C...

Last Updated   February 6, 2021 - 00:00

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OVERVIEW

  • Gender
    male
  • Age
    18+ years
  • Phase
    phase 3
    The drug or treatment is given to large groups of people to confirm its effectiveness, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
  • Sites
    368 sites
  • Status
    Recruiting

SUMMARY

The purpose of the study is to determine if the combination of niraparib with Abiraterone Acetate (AA) plus prednisone compared with AA plus prednisone in participants with deleterious germline or somatic Homologous Recombination Repair (HRR) gene-mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) provides superior efficacy in improving radiographic progression-free survival (rPFS).

CONDITIONS

  • Metastatic castrate sensitive prostate cancer

ELIGIBILITY

Inclusion criteria:

  • • Diagnosis of prostate adenocarcinoma
  • • Must have appropriate deleterious homologous recombination repair (HRR) gene alteration
  • • Metastatic disease as documented by at least one bone lesion
  • • Androgen deprivation therapy (either medical or surgical castration) must have been started >=14 days prior to randomization and willing to continue through the treatment phase.
  • • Other allowed prior therapy for metastatic castration-sensitive prostate cancer (mCSPC): (a) maximum of 1 course of radiation or surgical intervention to manage symptoms of prostate cancer. Radiation with curative intent is not allowed. Radiation must be completed prior to randomization (b) <= 6 months of androgen deprivation therapy (ADT) prior to randomization; and (c) 30 days of abiraterone acetate + prednisone (AA-P) allowed if required

Exclusion criteria:

  • • Prior treatment with a poly (adenosine diphosphate-ribose) polymerase (inhibitor) (PARP) inhibitor- History of adrenal dysfunction
  • • Long-term use of systemically administered corticosteroids (greater than [>] 5 milligrams [mg] of prednisone or the equivalent) during the study is not allowed. Short-term use (<=4 weeks, including taper) and locally administered steroids (for example, inhaled, topical, ophthalmic, and intra-articular) are allowed, if clinically indicated
  • • History or current diagnosis of myelodysplastic syndrome (MDS)/ acute myeloid leukemia (AML)

DETAILS

Prostate cancer is a heterogenous disease and recent genomic analyses have highlighted specific germline and somatic mutations and alternative driver growth signaling pathways in patients with metastatic disease. Abiraterone acetate plus prednisone (AA-P) is an established standard of care for the treatment of participants with mCSPC and is included in widely accepted clinical treatment guidelines. Niraparib is an investigational agent in the castration-sensitive cancer population and has been approved for the treatment of ovarian cancer. The addition of niraparib to the AA-P backbone regimen may improve initial disease control and long-term outcomes compared with AA-P alone in a biomarker selected population. The study will consist of 4 phases; a Prescreening Phase for biomarker evaluation for eligibility only, a Screening Phase, a Treatment Phase, and a Follow-up Phase. Efficacy evaluations include the following: tumor measurements by computed tomography (CT), magnetic resonance imaging (MRI; abdomen, chest, and pelvis), Technetium-99m (99mTc) bone scans, serum prostate sensitive antigen (PSA) evaluations, and patient reported outcomes (PROs). Safety evaluations include incidence of adverse events and clinical laboratory parameters.

LOCATIONS

Locations in:
Belgium, Netherlands, Israel, United States, Mexico, Czechia, China, Malaysia, Canada, Spain, Poland, Argentina, Australia, Bulgaria, United Kingdom, Turkey, Ukraine, Denmark, Sweden, Taiwan, Italy, South Africa, Germany, Hungary, Portugal, Brazil, Thailand, France, Belarus, Russia, New Zealand, South Korea
City or Province (368) Country (32) Status
Roeselare Algemeen Ziekenhuis Delta Belgium
Not yet recruiting
Nijmegen, GE Canisius-Wilhelminaziekenhuis Netherlands
Not yet recruiting
Tzrifin Yitzhak Shamir Medical Center Israel
Withdrawn
Phoenix, AZ Mayo Clinic Arizona United States
Not yet recruiting
Seattle, WA University of Washington United States
Not yet recruiting
Virginia Beach, VA Urology of Virginia, PLCC United States
Withdrawn
New York, NY Memorial Sloan Kettering Cancer Center United States
Not yet recruiting
San Diego, CA UCSD Moores Cancer Center United States
Not yet recruiting
Salt Lake City, UT University of Utah Huntsman Cancer Institute United States
Not yet recruiting
San Francisco, CA University of San Francisco California United States
Not yet recruiting
Bronx, NY Montefiore Medical Center United States
Not yet recruiting
Troy, MI Michigan Institute of Urology United States
Not yet recruiting
Philadelphia, PA University of Pennsylvania United States
Not yet recruiting
Orange, CA University of California Irvine Medical Center - Chao Family Comprehensive Cancer Center United States
Not yet recruiting
Tilburg Elisabeth-TweeSteden Ziekenhuis Netherlands
Not yet recruiting
Jerusalem Hadassah Hospital Israel
Not yet recruiting
Monterrey Avix Investigacion Clinica, S.C. Mexico
Not yet recruiting
Durango, DUR Consultorio de Especialidad en Urologia Privado Mexico
Not yet recruiting
Zapopan, JAL Consultorio Privado Mexico
Not yet recruiting
Hradec Kralove FN Hradec Kralove, Urologicka klinika Czechia
Not yet recruiting
Praha 2 Urologicka klinika 1.LF UK a VFN Czechia
Not yet recruiting
Brno Fakultni nemocnice u sv. Anny v Brne Czechia
Not yet recruiting
Liberec Krajská nemocnice Liberec Czechia
Not yet recruiting
Olomouc Uromedical Center s.r.o. Czechia
Not yet recruiting
Chongqing, 97 Chongqing Cancer hospital China
Not yet recruiting
Nanchang The First Affiliated Hospital of NanChang University China
Not yet recruiting
Leon, GUA Consultorio Privado Mexico
Not yet recruiting
Monterrey i Can Oncology Center Mexico
Not yet recruiting
Oaxaca, OAX Consultorio de Oncología Médica Mexico
Not yet recruiting
Naucalpan Oncología Integral Satelite Mexico
Not yet recruiting
Kuala Lumpur N/a Hospital Kuala Lumpur Malaysia
Not yet recruiting
Vancouver, BC British Columbia Cancer Agency (BCCA) - Vancouver Centre Canada
Not yet recruiting
Jerez de la Frontera HOSP. DE JEREZ DE LA FRONTERA Spain
Not yet recruiting
Madrid, MD HOSP. UNIV. DE LA PRINCESA Spain
Not yet recruiting
Bydgoszcz Szpital Uniwersytecki NR 1 IM. Dr. Antoniego Jurasza Poland
Not yet recruiting
Lodz Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi Poland
Not yet recruiting
C.A.B.A., B Hospital Militar Cosme Argerich Argentina
Not yet recruiting
Ciudad De Buenos Aires, B Clínica Adventista Belgrano Argentina
Not yet recruiting
Cordoba Centro Urologico Profesor Bengio Argentina
Not yet recruiting
Mar Del Plata Hospital Privado de Comunidad Argentina
Not yet recruiting
Ciudad Automoma Buenos Aires, B Centro de Urologia (CDU) Argentina
Not yet recruiting
Pergamino Centro de Investigacion Pergamino SA Argentina
Not yet recruiting
Ciudad Autonoma de, B Hospital Italiano de Buenos Aires Argentina
Not yet recruiting
Caba, B Hospital Aleman Argentina
Not yet recruiting
South Brisbane, QLD ICON Cancer Care Australia
Not yet recruiting
Sofia UMHAT Sofia Med Bulgaria
Not yet recruiting
Vratsa Comprehensive Cancer Center Bulgaria
Not yet recruiting
Pleven UMHAT 'Dr. Georgi Stranski', EAD Bulgaria
Not yet recruiting
Sofia Specialized Hospital for Active Treatment in Oncology Bulgaria
Not yet recruiting
Burgas, 02 MHAT Deva Maria Bulgaria
Not yet recruiting
Toronto, ON Sunnybrook Health Sciences Center Canada
Not yet recruiting
SuZhou, 31 Second Affiliated Hospital of Soochow University China
Not yet recruiting
Guangzhou Guangzhou First Municipal People's Hospital China
Not yet recruiting
Guangzhou Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University China
Not yet recruiting
Beijing, 11 Beijing University Third Hospital China
Not yet recruiting
Barcelona, BA HOSP. DE LA SANTA CREU I SANT PAU Spain
Not yet recruiting
Madrid, MD HOSP. UNIV. 12 DE OCTUBRE Spain
Not yet recruiting
Girona, GI INSTITUT CATALÀ D'ONCOLOGIA GIRONA Spain
Not yet recruiting
Sevilla HOSP. VIRGEN DEL ROCIO Spain
Not yet recruiting
Surrey The Royal Marsden NHS Trust Sutton United Kingdom
Not yet recruiting
Preston, LAN Royal Preston Hospital United Kingdom
Not yet recruiting
Oxford, OXF Churchill Hospital United Kingdom
Not yet recruiting
Bristol Bristol Haematology and Oncology Centre United Kingdom
Not yet recruiting
Belfast Belfast City Hospital United Kingdom
Not yet recruiting
Ramat Gan Sheba Medical Center Tel Hashomer Israel
Not yet recruiting
Hilversum Tergooiziekenhuizen Netherlands
Not yet recruiting
Portland, OR Oregon Health & Science University United States
Not yet recruiting
Oklahoma City, OK Stephenson Cancer Center United States
Not yet recruiting
Chengdu Sichuan Provincial People's Hospital China
Not yet recruiting
Shanghai, 31 Huadong Hospital Affiliated to Fudan University China
Not yet recruiting
Suzhou The First Affliated Hospital of Soochow University China
Not yet recruiting
Izmir Dokuz Eylül University Medical Faculty Turkey
Not yet recruiting
Adana, ADA Adana Baskent Yuregir Hospital Turkey
Not yet recruiting
Ankara, ANK Ankara University Medical Faculty Turkey
Not yet recruiting
Istanbul Istanbul University Istanbul Medical Faculty Turkey
Not yet recruiting
Dnipro Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4 Ukraine
Not yet recruiting
Ivano-Frankivsk Ivano-Frankivsk Regional Clinical Hospital Ukraine
Not yet recruiting
Kharkiv Regional Medical Clinical Center for Urology and Nephrology named after V.I. Shapoval Ukraine
Not yet recruiting
Khakhiv Municipal non-profit enterprise 'Regional Center of Oncology' Ukraine
Not yet recruiting
Kamianske Communal Institution 'City hospital №7 of Kamianske' of Dnepropetrov'sk Regional Council Ukraine
Not yet recruiting
Kyiv State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center Ukraine
Not yet recruiting
Kyiv State Institution National Cancer Institute Ukraine
Not yet recruiting
Dnipro Municipal Institution 'Clinical Oncology Dispensary' Under Dnipropetrovsk Regional Council Ukraine
Not yet recruiting
Chernivtsi Municipal Non-profit enterprise 'Bukovinian clinical oncology center' Ukraine
Not yet recruiting
Copenhagen Copenhagen University Hospital Denmark
Not yet recruiting
Vejle Vejle Hospital Denmark
Not yet recruiting
Naestved Næstved Hospital Denmark
Not yet recruiting
Aalborg Aalborg University Hospital Denmark
Not yet recruiting
Malmö Urologiska Mottagningen Sweden
Not yet recruiting
Göteborg Salgrenska University hospital Sweden
Not yet recruiting
Stockholm Södersjukhuset Sweden
Not yet recruiting
Bursa, BRS Bursa Yuksek lhtisas EAH Medikal Onkoloji Klinigi Turkey
Not yet recruiting
ISTANBUL ISTANBUL UNIVERSITESI CERRAHPASA TIP FAKULTESI IC HASTALIKLARI ANABILIM DALI MEDIKAL ONKOLOJI BD Turkey
Not yet recruiting
Kaohsiung City Kaohsiung Chang Gung Memorial Hospital Taiwan
Not yet recruiting
Darlinghurst, NSW St. Vincent's Hospital Sydney Australia
Not yet recruiting
Birtinya, QLD Sunshine Coast University Hospital Australia
Not yet recruiting
Liege, WLG CHC MontLegia Belgium
Not yet recruiting
Shanghai, 31 The Fifth People's Hospital of Shanghai, Fudan University China
Not yet recruiting
Wenzhou The First Affiliated Hospital of Wenzhou Medical University China
Not yet recruiting
Odense Odense Universitetshospital Denmark
Not yet recruiting
Tel-Aviv Tel-Aviv Sourasky Medical Center Israel
Not yet recruiting
Padova Istituto Oncologico Veneto Iov Irccs Padova Italy
Not yet recruiting
Trento OSPEDALE S. CHIARA Italy
Not yet recruiting
Lecce Azienda Ospedaliera ''Vito Fazzi'' Italy
Not yet recruiting
Milano Ospedale San Raffaele Italy
Not yet recruiting
Pisa Azienda Ospedaliero Universitaria Pisana Italy
Not yet recruiting
Arezzo OSPEDALE S. DONATO - ASL 8 AREZZO Italy
Not yet recruiting
San Giovanni Rotondo Casa Sollievo della Sofferenza, IRCCS Italy
Not yet recruiting
Milano European Institute of Oncology Italy
Not yet recruiting
Cremona Istituti Ospitalieri di Cremona, AO di Cremona Italy
Not yet recruiting
Napoli Fondazione G. Pascale - Istituto Nazionale Tumori IRCCS Italy
Not yet recruiting
Milano Fondazione IRCCS Istituto Nazionale dei Tumori Italy
Not yet recruiting
Pozzuoli ASL Napoli 2 Nord-SM delle Grazie Hospital Italy
Not yet recruiting
Candiolo Divisione di Oncologia - Istituto per la ricerca e cura del cancro Italy
Not yet recruiting
Meldola Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Italy
Not yet recruiting
Orbassano Aou San Luigi Gonzaga Italy
Not yet recruiting
Vicenza Ospedale San Bortolo Italy
Not yet recruiting
Pretoria, GT Steve Biko Academic Hospital South Africa
Not yet recruiting
Murdoch, WA Fiona Stanley Hospital Australia
Not yet recruiting
Chengdu Western Theater General Hospital of the Chinese People's Liberation Army China
Not yet recruiting
Beijing, 11 Beijing Friendship Hospital, Capital Medical University China
Not yet recruiting
Muenster Universitaetsklinikum Muenster Germany
Not yet recruiting
Braunschweig Städtisches Klinikum Braunschweig gGmbH - Standort Salzdahlumer Germany
Not yet recruiting
Koeln Universitaetsklinikum Koeln Germany
Not yet recruiting
Duisburg Urologicum Duisburg Germany
Not yet recruiting
Hannover Medizinische Hochschule Hannover Germany
Not yet recruiting
MUENCHEN Klinikum rechts der Isar - III. Med. Klinik und Poliklinik Germany
Not yet recruiting
Hamburg, HH Urologikum Hamburg Germany
Not yet recruiting
Nuertingen, BW Studienpraxis Urologie Drs. Feyerabend Germany
Not yet recruiting
Dresden, SN Universitätsklinik Carl Gustav Carus, Med. Klinik u. Poliklinik I Germany
Not yet recruiting
Miskolc Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz Hungary
Not yet recruiting
Coimbra, Coimbra Instituto Português de Oncologia Francisco Gentil - Centro Regional de Oncologia de Coimbra, S.A. Portugal
Not yet recruiting
Lisboa Fundação Champalimaud Portugal
Not yet recruiting
Lisboa CHLN - HOSP. SANTA MARIA Portugal
Not yet recruiting
Almada HOSP. GARCIA DE ORTA Portugal
Not yet recruiting
Rio De Janeiro, RJ Oncoclínicas Brazil
Not yet recruiting
EDMONTON, AB Cross Cancer Institute Canada
Not yet recruiting
Montreal, QC McGill University - Jewish General Hospital Canada
Not yet recruiting
Ciudad de Mexico Centro de Investigación Clínica Gramel S.C. Mexico
Not yet recruiting
Sao Paulo, SP IBCC Instituto Brasileiro de Controle do Cancer Brazil
Not yet recruiting
Porto Alegre, RS Hospital Ernesto Dornelles Brazil
Not yet recruiting
Sorocaba, SP IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado Brazil
Not yet recruiting
São Paulo, SP Hospital Samaritano de São Paulo Brazil
Not yet recruiting
Rio de Janeiro, RJ Hospital Universitário Pedro Ernesto Brazil
Not yet recruiting
Ijui Hospital de Caridade de Ijui - CACON Brazil
Not yet recruiting
Florianópolis, SC Centro de Pesquisas Oncológicas - CEPON Brazil
Not yet recruiting
Joinville, SC Instituto Joinvilense De Hematologia e Oncologia Brazil
Not yet recruiting
Salvador Núcleo de Oncologia da Bahia Brazil
Not yet recruiting
Belo Horizonte PERSONAL - Oncologia de Precisão e Personalizada Brazil
Not yet recruiting
São Paulo, SP Instituto de Assistência Médica ao Servidor Público Estadual - HSPE-FMO Brazil
Not yet recruiting
Sao Paulo, SP Santa Casa de Misericordia de São Paulo Brazil
Not yet recruiting
Sao Paulo, SP INSTITUTO DE ENSINO E PESQUISA SAO LUCAS Brazil
Not yet recruiting
Porto Alegre IRMANDADE SANTA CASA DE MISERICORDIA DE PORTO ALEGRE Brazil
Not yet recruiting
Belo Horizonte, MG Cetus Oncologia Brazil
Not yet recruiting
BARRETOS, SP Hospital Do Cancer De Barretos - Fundacao Pio Xii Brazil
Not yet recruiting
Goiânia Hospital Araújo Jorge da Associação de Combate ao Câncer em Goiás Brazil
Not yet recruiting
Ipatinga, MG Fundação São Francisco Xavier Brazil
Not yet recruiting
SAO PAULO, SP ICESP - INSTITUTO DO CANCER DO ESTADO DE SAO PAULO OCTAVIO FRIAS de OLIVEIRA Brazil
Not yet recruiting
Rio de Janeiro, RJ Instituto COI de Pesquisa, Educacao e Gestao Brazil
Not yet recruiting
Recife MultiHemo Brazil
Not yet recruiting
Rio de Janeiro, RJ Instituto Nacional do Cancer - INCA Brazil
Not yet recruiting
Curitiba CIONC - Centro Integrado de Oncologia de Curitiba Brazil
Not yet recruiting
Santo André, SP CEPHO - Faculdade de Medicina do ABC Brazil
Not yet recruiting
Natal, RN Liga Norte Riograndense Contra O Cancer Brazil
Not yet recruiting
Sao Paulo, SP Centro de Pesquisa do Instituto do Cancer Arnaldo Vieira de Carvalho Brazil
Not yet recruiting
Salvador Hospital Sao Rafael Brazil
Not yet recruiting
Herston, QLD Royal Brisbane and Women's Hospital Australia
Not yet recruiting
Subiaco, WA St John of God Subiaco Hospital Australia
Not yet recruiting
Hillingdon Marie Curie Research Wing - Mount Vernon Hospital United Kingdom
Not yet recruiting
Vosloorus, GT East Rand Urology Research Unit South Africa
Not yet recruiting
Bangkok, 10 Ramathibodi Hospital Thailand
Not yet recruiting
Bangkok, 10 Siriraj Hospital Thailand
Not yet recruiting
Bangkok, 10 King Chulalongkorn Memorial Hospital Thailand
Not yet recruiting
Philadelphia, PA Thomas Jefferson University United States
Withdrawn
Nijmegen, GE UMC Radboud Netherlands
Withdrawn
Shanghai, 31 Fudan University Shanghai Cancer Center China
Not yet recruiting
BeiJing, 11 Beijing Hospital China
Not yet recruiting
Beijing, 11 Beijing Cancer Hospital China
Not yet recruiting
GuangZhou Sun Yat-Sen University Cancer Center China
Not yet recruiting
Shanghai, 31 Renji Hospital Affiliated to Medical College of Shanghai Jiaotong University China
Not yet recruiting
Shanghai, 31 Zhongshan Hospital,Fudan University China
Not yet recruiting
Beijing, 11 Cancer Hospital Chinese Academy of Medical Sciences China
Not yet recruiting
Shenyang Shengjing Hospital of China Medical University China
Not yet recruiting
Hangzhou Zhejiang Provincial People's Hospital China
Not yet recruiting
Ningbo Ningbo First Hospital China
Not yet recruiting
Nanjing Jiangsu Province Cancer Hospital China
Not yet recruiting
Chengdu West China Hospital of Sichuan University China
Not yet recruiting
Nanjing Nanjing Drum Tower Hospital China
Not yet recruiting
Shanghai, 31 Huashan Hospital Fudan University China
Not yet recruiting
Xi'an The First Affiliated Hospital of Xi'an Jiaotong University China
Not yet recruiting
Wuhan TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology China
Not yet recruiting
Chongqing, 97 Southwest Hospital, The Third Military Medical University China
Not yet recruiting
Lille Centre Oscar Lambret France
Not yet recruiting
Strasbourg Clinique Sainte Anne France
Not yet recruiting
Saint-Priest-en-Jarez Institut de Cancérologie de Loire France
Not yet recruiting
SAINT MANDE HIA Begin France
Not yet recruiting
AVIGNON CEDEX 9 Institut Sainte Catherine France
Not yet recruiting
Dijon Centre Georges François Leclerc France
Not yet recruiting
Tours CHRU de Tours France
Not yet recruiting
Quimper Centre Hopitalier Inter-Communal De Cornouaille France
Not yet recruiting
Montpellier Institut Regional du Cancer de Montpellier Val d'Aurelle France
Not yet recruiting
Suresnes Hopital Foch France
Not yet recruiting
LYON Hopital Prive Jean Mermoz France
Not yet recruiting
Ris Orangis Centre de radiothérapie et d'Oncologie médicale de l'Essonne France
Not yet recruiting
Pittsburgh, PA University of Pittsburgh Medical Center (UPMC) United States
Not yet recruiting
New Orleans, LA Ochsner Clinic Foundation United States
Not yet recruiting
Angers Cedex 9 Institut de Cancérologie de l'Ouest (ICO) France
Not yet recruiting
Gomel Gomel Regional Clinical Oncology Dispensary Belarus
Not yet recruiting
Mogilev Mogilev Regional Hospital Belarus
Not yet recruiting
Brest Brest Regional Oncology Dispensary Belarus
Not yet recruiting
Lesnoy State Institution N.N. Alexandrov Republican Scientific and Belarus
Not yet recruiting
Moscow Hertzen Oncology Research Institute Russia
Not yet recruiting
Nizhny Novgorod Privolzhsky District Medical Centre Russia
Not yet recruiting
Pyatigorsk LLC Novaya Clinica Russia
Not yet recruiting
Moscow Russian Scientific Center of Roentgenoradiology Russia
Not yet recruiting
Chelyabinsk Chelyabinsk Regional Clinical Center Of Oncology And Nuclear Medicine Russia
Not yet recruiting
Saint-Petersburg Leningrad Regional Oncology Dispensary Russia
Not yet recruiting
Moscow Moscow City Clinical Hospital # 62 Russia
Not yet recruiting
Omsk Clinical Oncology Dispensary Russia
Not yet recruiting
Kursk GUZ Kursk Regional Oncology Dispensary Russia
Not yet recruiting
Tyumen Medical-sanitary unit 'Neftyanik' Russia
Not yet recruiting
Saint Petersburg Private Medical Institution Euromedservice Russia
Not yet recruiting
Ivanovo Ivanovo Regional Oncology Dispensary Russia
Not yet recruiting
Saint-Petersburg Russian Scientific Center of Radiology and Surgical Technologies Russia
Not yet recruiting
Saransk Republican Oncology Dispensary Russia
Not yet recruiting
Sochi Oncologic Dispensary No.2 Russia
Not yet recruiting
Tomsk Tomsk Cancer Research Institute Russia
Not yet recruiting
Barnaul Altai Regional Oncology Dispensary Russia
Not yet recruiting
Pyatigorsk Pyatigorsk Regional Oncology Dispensary Russia
Not yet recruiting
Ufa Bashkir State Medical University Russia
Not yet recruiting
Minsk Minsk city Clinical Oncological Dispensary Belarus
Not yet recruiting
Vitebsk Vitebsk Regional Clinical Hospital Belarus
Not yet recruiting
Grodno Grodno University Hospital Belarus
Not yet recruiting
Bobruisk Bobruisk Interregional Oncological Dispensary Belarus
Not yet recruiting
Hamilton, ON McMaster Institute of Urology Canada
Not yet recruiting
Poitiers Cedex CHU De Poitiers France
Not yet recruiting
Herlev Herlev Hospital Denmark
Not yet recruiting
Warszawa Szpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o. Poland
Not yet recruiting
Syracuse, NY Associated Medical Professionals United States
Recruiting
Auckland, AUK Auckland City Hospital New Zealand
Not yet recruiting
Uppsala Akademiska Sjukhuset Sweden
Withdrawn
Tucson, AZ Urological Associates of Southern Arizona, P.C. United States
Recruiting
San Bernardino, CA San Bernardino Urological Associates United States
Recruiting
Praha 4 Thomayerova nemocnice Czechia
Withdrawn
LIVERPOOL, NSW Liverpool Hospital Australia
Not yet recruiting
Dunedin Central, OTA Dunedin Hospital New Zealand
Not yet recruiting
New York, NY Mount Sinai United States
Not yet recruiting
Cape Town, WC CancerCare Rondebosch South Africa
Not yet recruiting
Ankara, ANK Memorial Ankara Hastanesi Turkey
Not yet recruiting
Kelowna, BC British Columbia Cancer Agency(BCCA)-Sindi Ahluwalia Hawkins Centre for the Southern Interior(CSI) Canada
Not yet recruiting
Christchurch, CAN Canterbury Urology Research Trust New Zealand
Not yet recruiting
São Paulo, SP Hospital Beneficência Portuguesa de São Paulo Brazil
Not yet recruiting
Changsha Hunan Cancer hospital China
Withdrawn
Yantai Yantai Yuhuangding Hospital China
Withdrawn
Lancaster, PA Lancaster Urology United States
Not yet recruiting
Haine-St-Paul, WHT Jolimont Belgium
Recruiting
Nashville, TN Urology Associates United States
Recruiting
Namur CHU UCL Namur - Site Sainte Elisabeth Belgium
Recruiting
Ottignies Clinique St Pierre Belgium
Recruiting
Gdynia Szpitale Pomorskie Sp. z o.o. Poland
Recruiting
Siedlce Urologica Praktyka Lekarska Adam Marcheluk Poland
Recruiting
Kurralta Park, SA Ashford Cancer Centre Australia
Recruiting
Pleven UMHAT 'Dr. Georgi Stranski', EAD Bulgaria
Withdrawn
Plovdiv Complex Oncology Center - Plovdiv EOOD Bulgaria
Withdrawn
Great Maze Pond Guy's Hospital United Kingdom
Not yet recruiting
Jeffersonville, IN First Urology United States
Recruiting
Kaohsiung Kaohsiung Medical University Chung-Ho Memorial Hospital Taiwan
Recruiting
Taichung Tungs' Taichung MetroHarbor Hospital Taiwan
Recruiting
Mettmann, NW Urologie Neandertal Praxis Mettmann Germany
Withdrawn
Albany, NY New York Oncology Hematology United States
Recruiting
Fortaleza Pronutrir Brazil
Not yet recruiting
Charleroi, WHT Grand Hôpital de Charleroi, site Notre Dame Belgium
Recruiting
Houston, TX Houston Metro Urology United States
Recruiting
Towson, MD Chesapeake Urology Associates United States
Recruiting
Haifa, H Rambam Medical Center Israel
Recruiting
Petach Tikvah Rabin Medical Center, Beilinson Hospital Israel
Recruiting
Taichung China Medical University Hospital Taiwan
Recruiting
A Coruña HOSP. UNIV. A CORUÑA Spain
Recruiting
Castellon HOSP. GRAL. UNIV. DE CASTELLON Spain
Recruiting
Konin Przychodnia Lekarska KOMED Roman Karaszewski Poland
Recruiting
Santander, CT HOSP. UNIV. MARQUES DE VALDECILLA Spain
Recruiting
Valencia, VC HOSP. CLINICO UNIV. DE VALENCIA Spain
Recruiting
Madrid, MD HOSP. UNIV. LA PAZ Spain
Recruiting
Brighton Brighton and Sussex University Hospitals NHS Trust United Kingdom
Not yet recruiting
Truro, CON Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital United Kingdom
Recruiting
Taipei Taipei Veterans General Hospital Taiwan
Recruiting
North Ryde, NSW Macquarie University Hospital Australia
Recruiting
Melbourne, VIC Peter MacCallum Cancer Centre Australia
Recruiting
Budapest Országos Onkológiai Intézet, C Belgyógyászati-Onkológiai és Klinikai Farmakológiai Osztály Hungary
Withdrawn
Budapest UZSOKI UTCAI KORHAZ Hungary
Withdrawn
Budapest Semmelweis Egyetem, Urológia Klinika Hungary
Withdrawn
Germantown, TN West Cancer Center United States
Withdrawn
Charleston, SC Ralph H. Johnson Veterans Affairs Medical Center United States
Not yet recruiting
Daytona Beach, FL Advanced Urology Institute United States
Not yet recruiting
Homewood, AL Urology Centers Of Alabama United States
Not yet recruiting
Plovdiv District Oncology Dispensary with In-Patient Stationary - Plovdiv Bulgaria
Not yet recruiting
Bordeaux Institut Bergonié France
Not yet recruiting
Marseilli Hôpital Privé Clairval France
Not yet recruiting
Vinnitsa Podilskiy Regional Center of Oncology Ukraine
Not yet recruiting
Zhytomyr Communal Institution 'Regional Oncology Dispensary' of Zhytomyr Region Council Ukraine
Not yet recruiting
Kyiv Kyiv Regional Oncological Dispensary Ukraine
Not yet recruiting
Kherson Kherson Regional Oncological Dispensary Ukraine
Not yet recruiting
Denver, CO Colorado Permanente Medical Group United States
Not yet recruiting
Wilrijk GZA Ziekenhuizen Belgium
Recruiting
Beer-Sheva Soroka Hospital Israel
Recruiting
Taichung Taichung Veterans General Hospital Taiwan
Recruiting
Johor Bahru, JH Hospital Sultan Ismail Malaysia
Recruiting
Kuala Lumpur University Malaya Medical Centre Malaysia
Recruiting
George Town Hospital Pulau Pinang Malaysia
Recruiting
Madrid, MD HOSP. UNIV. RAMON Y CAJAL Spain
Recruiting
Bydgoszcz Centrum Onkologii im. Prof. F. Lukaszczyka Poland
Recruiting
Ciudad Autonoma de Buenos Aires, B Cinme - Centro De Investigaciones Metabolicas Argentina
Recruiting
Buenos Aires, B Hospital Sirio Libanes Argentina
Recruiting
Capital Federal, B Fundación CENIT para la Investigación en Neurociencias Argentina
Recruiting
Cordoba Hospital Privado de Cordoba Argentina
Recruiting
Cordoba, X Cemaic - Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica Argentina
Recruiting
San Salvador De Jujuy, Y ARS Médica Argentina
Recruiting
Calgary, AB Prostate Cancer Centre Canada
Recruiting
Toronto, ON University Health Network (UHN) Princess Margaret Cancer Centre Canada
Not yet recruiting
Montreal, QC Centre Hospitalier de l'Universite de Montreal Canada
Not yet recruiting
Kingston, ON Kingston Health Sciences Centre, Kingston General Health Research Institute Canada
Recruiting
Málaga HOSP. VIRGEN DE LA VICTORIA Spain
Recruiting
Sabadell, BA CORPORACIO SANITARI PARC TAULI Spain
Recruiting
Barcelona, BA HOSP. CLINIC I PROVINCIAL DE BARCELONA Spain
Recruiting
Madrid, MD HOSP. UNIV. HM MONTEPRINCIPE Spain
Recruiting
London University College London Hospitals NHSFT United Kingdom
Recruiting
Putrajaya, PJ Institut Kanser Negara - Clinical Research Center Malaysia
Recruiting
Sakarya, SAK Sakarya University Training and Research Hospital Turkey
Recruiting
Taipei National Taiwan University Hospital. Taiwan
Recruiting
Lviv Communal Noncommercial Enterprise of Lviv Regional Council 'Lviv Regional Clinical Hospital' Ukraine
Not yet recruiting
Manisa, MAN Manisa Celal Bayar University Turkey
Withdrawn
İstanbul T.C. Saglik Bakanlıgi Goztepe Prof. Dr. Suleyman Yalcın Sehir Hastanesi Turkey
Not yet recruiting
Seongnam-si, 41 Seoul National University Bundang Hospital South Korea
Recruiting
Seoul Severance Hospital South Korea
Recruiting
Suwon, 41 Ajou University Hospital South Korea
Recruiting
Gwangju Chonnam National University Hospital South Korea
Recruiting
Seoul Asan Medical Center South Korea
Recruiting
Seoul The Catholic University of Korea, Seoul St. Mary's Hospital South Korea
Recruiting
Seoul Samsung Medical Center South Korea
Recruiting
Busan Pusan National University Hospital South Korea
Recruiting
Seoul Seoul National University Hospital South Korea
Recruiting
Goyang-si, 41 National Cancer Center South Korea
Recruiting
Wroclaw Specjalistyczna przychodnia lekarska POLIMED Poland
Recruiting
Denver, CO The Urology Center of Colorado United States
Recruiting
Golden, CO Foothills Urology - Golden Off United States
Recruiting
Beijing, 11 Peking University First Hospital China
Not yet recruiting
Tyler, TX Texas Oncology-Tyler United States
Recruiting
Lyon Centre Leon Bérard France
Not yet recruiting
Colorado Springs, CO Rocky Mountain Cancer Centers United States
Recruiting
Tauranga, BOP TAURANGA HOSPITAL New Zealand
Not yet recruiting
NANCY POLYCLINIQUE DE GENTILLY France
Not yet recruiting
Besancon CHRU De Besancon France
Not yet recruiting
Omaha, NE GU Research Network United States
Recruiting
Kuching, SR Sarawak General Hospital Malaysia
Recruiting
Cherkasy Communal Nonprofit Enterprise 'Cherkasy Regional Oncology Dispensary Of Cherkasy Regional Council' Ukraine
Recruiting
Dnipro CE 'DNIPROPETROVSK REGIONAL CLINICAL HOSPITAL N.A. MECHNIKOV' OF DNIPROPETROVSK RC Ukraine
Recruiting
Stockholm Karolinska Universitetssjukhuset Solna Sweden
Not yet recruiting
Ankara, ANK Ankara Bilkent City Hospital Turkey
Recruiting
Taoyuan Chang-Gung Memorial Hospital, LinKou Branch Taiwan
Recruiting
Daegu Kyungpook National University Chilgok Hospital South Korea
Recruiting
Daejeon Chungnam National University Hospital South Korea
Recruiting
Seoul Gangnam Severance Hospital South Korea
Recruiting
Daegu Keimyung University Dongsan Hospital South Korea
Recruiting
Hobart, TAS Royal Hobart Hospital Australia
Recruiting
Szeged Szegedi Tudomanyegyetem Hungary
Recruiting
Afula Haemek Medical Center - Afula Israel
Recruiting
Delft Reinier de Graaf Gasthuis Netherlands
Not yet recruiting
Seneca, SC Prisma Health United States
Recruiting
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50

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5

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