A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma (RedirecTT-1)

Last Updated   August 7, 2024

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CR108901

OVERVIEW

  • Sexes Eligible for Study
    all
  • Age
    18+ years
  • Phase
    phase 1
    1
  • Sites
    40 Sites
  • Status
     Recruiting

SUMMARY

Multiple myeloma is a malignant plasma cell disorder characterized by production of monoclonal proteins (M proteins), which are comprised of pathologic immunoglobulins (Ig) or fragments of such, which have subsequently lost their normal function. Rationale for combining talquetamab and teclistamab is the targeting of multiple proteins on the surface of multiple myeloma cells resulting in cell lysis. This study consists of 3 periods: screening phase (up to 28 days), treatment phase (start of study drug administration and continues until the completion of the end of treatment [EOT] visit); and a post-treatment follow-up phase (after end of treatment and up to 16 weeks after last dose of study drug(s) for each participant). End of study is defined as 2 years after the last participant has received his or her initial dose of the treatment combination. Total duration of study is Approximately 5 years. Efficacy, safety, pharmacokinetics (PK), immunogenicity, and biomarkers will be assessed at specified time points during this study. Participants safety and study conduct will be monitored throughout the study.

CONDITIONS

  • Multiple Myeloma

ELIGIBILITY


Inclusion Criteria:

* Documented initial diagnosis of multiple myeloma according to International Myeloma Working Group (IMWG) diagnostic criteria
* Part 1 and 2: Participant could not tolerate or has disease that is relapsed or refractory to established therapies, including the

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DETAILS

LOCATIONS

Locations in:
United States, Australia, Canada, Israel, Japan, South Korea, Spain
Country (7) City or Province (40) Status
United States Birmingham University of Alabama at Birmingham, Comprehensive Cancer Center
RECRUITING
United States Little Rock University of Arkansas for Medical Sciences
RECRUITING
United States Denver Colorado Blood Cancer Institute
RECRUITING
United States Atlanta Emory University
RECRUITING
United States Rochester Mayo Clinic
RECRUITING
United States Saint Louis Washington University in St. Louis
RECRUITING
United States New York Mount Sinai Medical Center
RECRUITING
United States New York Memorial Sloan Kettering Cancer Center
RECRUITING
United States Charlotte Atrium Health
RECRUITING
United States Winston-Salem Wake Forest University Baptist Medical Center (WFUBMC) - Comprehensive Cancer Center
RECRUITING
United States Cleveland Cleveland Clinic
RECRUITING
United States Portland Oregon Health And Science University
RECRUITING
United States Houston The University of Texas MD Anderson Cancer Center
RECRUITING
Australia Fitzroy St Vincents Hospital Melbourne
RECRUITING
Australia Perth Royal Perth Hospital
RECRUITING
Canada Calgary Tom Baker Cancer Centre
RECRUITING
Canada Edmonton Alberta Health Services
RECRUITING
Canada Toronto Princess Margaret Cancer Centre University Health Network
RECRUITING
Canada Montreal McGill University Health Centre
RECRUITING
Israel Jerusalem Hadassah Medical Center
RECRUITING
Israel Ramat Gan Sheba Medical Center
RECRUITING
Israel Tel-Aviv Tel-Aviv Sourasky Medical Center
RECRUITING
Japan Kanazawa Kanazawa University Hospital
RECRUITING
Japan Nagoya Nagoya City University Hospital
RECRUITING
Japan Osaka Osaka University Hospital
RECRUITING
Japan Sendai shi Tohoku University Hospital
RECRUITING
Japan Shibuya Japanese Red Cross Medical Center
RECRUITING
South Korea Seoul Seoul National University Hospital
RECRUITING
South Korea Seoul Severance Hospital Yonsei University Health System
RECRUITING
South Korea Seoul Asan Medical Center
RECRUITING
South Korea Seoul Samsung Medical Center
RECRUITING
South Korea Seoul The Catholic University of Korea Seoul St Marys Hospital
RECRUITING
Spain Badalona Hosp. Univ. Germans Trias I Pujol
RECRUITING
Spain Barcelona Hosp Clinic de Barcelona
RECRUITING
Spain L Hospitalet De Llobregat Inst. Cat. Doncologia-H Duran I Reynals
RECRUITING
Spain Madrid Hosp Univ Fund Jimenez Diaz
RECRUITING
Spain Madrid UNIV. HOSP. October 12
RECRUITING
Spain Pamplona Clinica Univ. de Navarra
RECRUITING
Spain Salamanca Hosp Clinico Univ de Salamanca
RECRUITING
Spain Santander Hosp. Univ. Marques de Valdecilla
RECRUITING
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Geo Locations

33.52066, -86.80249

34.74648, -92.28959

39.73915, -104.9847

33.749, -84.38798

44.02163, -92.4699

38.62727, -90.19789

40.71427, -74.00597

40.71427, -74.00597

35.22709, -80.84313

36.09986, -80.24422

41.4995, -81.69541

45.52345, -122.67621

29.76328, -95.36327

-37.79839, 144.97833

-31.95224, 115.8614

51.05011, -114.08529

53.55014, -113.46871

43.70011, -79.4163

45.50884, -73.58781

31.76904, 35.21633

32.08227, 34.81065

32.08088, 34.78057

36.6, 136.61667

35.18147, 136.90641

34.69374, 135.50218

38.26667, 140.86667

35.469, 140.29807

37.566, 126.9784

37.566, 126.9784

37.566, 126.9784

37.566, 126.9784

37.566, 126.9784

41.45004, 2.24741

41.38879, 2.15899

41.3491194, 2.1229311

40.4165, -3.70256

40.4165, -3.70256

42.81687, -1.64323

40.96882, -5.66388

43.46472, -3.80444

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50

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10

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5

Indicates < 10 sites in this region: click to zoom in.

Corresponds to individual site.

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