A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel

Last Updated   August 7, 2024

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CR109123

OVERVIEW

  • Sexes Eligible for Study
    all
  • Age
    18+ years
  • Phase
    phase 4
    4
  • Sites
    45 Sites
  • Status
     Recruiting

SUMMARY

Cilta-cel (JNJ-68284528/LCAR-B38M chimeric antigen receptor T-cells [CAR-T]) is an autologous CAR-T therapy that targets B-cell maturation antigen (BCMA), a molecule expressed on the surface of mature B lymphocytes and malignant plasma cells. There will be no treatment administered during the study and the data obtained from this study will help to assess whether there will be long-term cilta-cel-related toxicities. The study will consist of 2 phases: within the first 5 years after receiving the last dose of cilta-cel and Year 6 to 15 years after last dose of cilta-cel. Safety evaluations will include a review of adverse events, laboratory test results, and physical examination findings (including neurological examination). The duration of the study is up to 15 years after last dose of cilta-cel and participants will be followed at least once per year.

CONDITIONS

  • Multiple Myeloma

ELIGIBILITY


Inclusion Criteria:

* Participants who have received at least one dose of cilta-cel in a Company-sponsored clinical study
* Participants who have provided informed consent for this study

DETAILS

LOCATIONS

Locations in:
United States, Belgium, China, France, Israel, Japan, Netherlands, Spain
Country (8) City or Province (45) Status
United States Phoenix Mayo Clinic Cancer Center-Scottsdale
RECRUITING
United States Duarte City of Hope
RECRUITING
United States San Francisco University of California San Francisco
RECRUITING
United States Stanford Stanford University Medical Center
RECRUITING
United States Atlanta Emory University
RECRUITING
United States Chicago Northwestern University
RECRUITING
United States Chicago University of Chicago
RECRUITING
United States Indianapolis Indiana University
RECRUITING
United States Westwood Kansas University Medical Center
RECRUITING
United States Boston Dana Farber Cancer Institute
RECRUITING
United States Boston Beth Israel Deaconess Medical Center
RECRUITING
United States Boston Massachusetts General Hospital
RECRUITING
United States Detroit Barbara Ann Karmanos Cancer Institute
RECRUITING
United States Rochester Mayo Clinic Rochester
RECRUITING
United States Saint Louis Washington University School Of Medicine
RECRUITING
United States Hackensack Hackensack University Medical Center
RECRUITING
United States New Brunswick Rutgers Cancer Institute of New Jersey
RECRUITING
United States Bronx Montefiore Medical Center
RECRUITING
United States Buffalo Roswell Park Cancer Institute
RECRUITING
United States New York Mount Sinai Medical Center
RECRUITING
United States New York Memorial Sloan Kettering Cancer Center
RECRUITING
United States Charlotte Levine Cancer Institute
RECRUITING
United States Philadelphia University of Pennsylvania
RECRUITING
United States Pittsburgh University of Pittsburgh Medical Center
RECRUITING
United States Nashville Sarah Cannon Research Institute
RECRUITING
United States Houston MD Anderson Cancer Center
RECRUITING
United States Milwaukee Froedtert Memorial
RECRUITING
Belgium Gent UZ Gent
RECRUITING
Belgium Leuven UZ Leuven
RECRUITING
China Beijing Peking University Third Hospital
RECRUITING
China Chengdu West China Hospital Si Chuan University
RECRUITING
China Fuzhou Fujian Medical University Union Hospital
RECRUITING
China Hangzhou First Hospital, Zhejiang University Medical College
RECRUITING
China Nanjing Jiangsu Province Hospital
RECRUITING
China Shanghai Ruijin Hospital Shanghai Jiao Tong University
RECRUITING
China Shanghai Shanghai Fourth People s Hospital
RECRUITING
China Xi'an The Second Affiliated Hospital of Xi'an Jiaotong University
RECRUITING
France Nord CHRU de Lille Hopital Claude Huriez
RECRUITING
Israel Tel-Aviv Tel-Aviv Sourasky Medical Center
RECRUITING
Japan Nagoya Nagoya City University Hospital
ACTIVE_NOT_RECRUITING
Japan Shibuya Japanese Red Cross Medical Center
ACTIVE_NOT_RECRUITING
Netherlands Amsterdam VU Medisch Centrum
RECRUITING
Netherlands Groningen University Medical Center Groningen
RECRUITING
Spain Pamplona Clinica Univ. de Navarra
RECRUITING
Spain Salamanca Hosp Clinico Univ de Salamanca
RECRUITING
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Geo Locations

33.44838, -112.07404

34.13945, -117.97729

37.77493, -122.41942

37.42411, -122.16608

33.749, -84.38798

41.85003, -87.65005

41.85003, -87.65005

39.76838, -86.15804

39.04056, -94.6169

42.35843, -71.05977

42.35843, -71.05977

42.35843, -71.05977

42.33143, -83.04575

44.02163, -92.4699

38.62727, -90.19789

40.88593, -74.04347

40.48622, -74.45182

40.84985, -73.86641

42.88645, -78.87837

40.71427, -74.00597

40.71427, -74.00597

35.22709, -80.84313

39.95233, -75.16379

40.44062, -79.99589

36.16589, -86.78444

29.76328, -95.36327

43.0389, -87.90647

51.05, 3.71667

50.87959, 4.70093

39.9075, 116.39723

30.66667, 104.06667

26.06139, 119.30611

30.29365, 120.16142

32.06167, 118.77778

31.22222, 121.45806

31.22222, 121.45806

34.25833, 108.92861

50.197766, 3.378209

32.08088, 34.78057

35.18147, 136.90641

35.469, 140.29807

52.37403, 4.88969

53.21917, 6.56667

42.81687, -1.64323

40.96882, -5.66388

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50

Indicates 50+ sites in this region: click to zoom in.

10

Indicates 10+ sites in this region: click to zoom in.

5

Indicates < 10 sites in this region: click to zoom in.

Corresponds to individual site.

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