A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC) (SunRISe-3)
Last Updated August 14, 2024 - 21:06
OVERVIEW
-
Gender
all -
Age
years -
Phase
phase 3The drug or treatment is given to large groups of people to confirm its effectiveness, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely. -
Sites
sites -
Status
Recruiting
SUMMARY
Bladder cancer is the tenth most common malignancy worldwide. About 75 percent (%) of bladder cancers are non-muscle invasive at diagnosis with approximately 25% of NMIBC patients have HR, NMIBC. The TAR-200/gemcitabine (JNJ-17000139) product is an intravesical drug delivery system regulated as an investigational drug. The drug constituent consists of gemcitabine and osmotic minitablets. Cetrelimab (JNJ-63723283) is a fully human immunoglobulin G4 (IgG4) kappa monoclonal antibody (mAb) that binds programmed-cell death protein (PD)-1. The mainstay of treatment for HR-NMIBC is transurethral resection of bladder tumor, followed by intravesical treatment with BCG. In this study metronomic dosing of intravesical gemcitabine, delivered via TAR-200, alone or in combination with cetrelimab will be evaluated and compared against intravesical BCG. The study consists of a Screening phase, Treatment phase, and Follow-up phase. The total duration of the study will be up to 5 years and 2 months. Efficacy, Safety, pharmacokinetics (PK), and biomarkers will be assessed at specific time points during the study.
CONDITIONS
- Bladder Cancer
ELIGIBILITY
Inclusion Criteria:
* Histologically confirmed initial diagnosis by local pathology (within 90 days of the most recent signed informed consent) of high grade non-muscle invasive bladder cancer (HR-NMIBC) (high-grade Ta, any T1 or carcinoma in-situ [CIS]), in participants who are Bacillus Calmette Guérin (BCG)-naïve
* BCG-naïve (participants who have not received prior intravesical BCG or who previously received but stopped BCG more than 3 years before date of randomization are eligible)
* All visible papillary disease must be fully resected (absent) prior to date of randomization and documented at baseline cystoscopy. Local urine cytology at screening must be negative or atypical (for high-grade urothelial carcinoma [HGUC]) for patients with papillary only disease (without CIS)
* Eastern Cooperative Oncology Group (ECOG) performance status Grade 0, 1, or 2
* All adverse events associated with any prior surgery and/or intravesical therapy must have resolved to common terminology criteria for adverse events (CTCAE) version 5.0 Grade less than (<) 2 prior to date of randomization
* Participants must be willing to undergo all study procedures
Exclusion Criteria:
* Presence or history of histologically confirmed, muscle invasive, locally advanced, nonresectable, or metastatic urothelial carcinoma (that is, greater than and equal to [>=] T2)
* Must not have had urothelial carcinoma or histological variant at any site outside of the urinary bladder (that is, urethra, ureter, or renal pelvis). Ta/any T1/CIS of the upper urinary tract (including renal pelvis and ureter) is allowable if treated with complete nephroureterectomy more than 24 months prior to randomization
* Presence of any bladder or urethral anatomic feature (example, urethral stricture) that, in the opinion of the investigator, may prevent the safe insertion, indwelling use, removal of TAR-200 or administration of intravesical BCG. Participants with tumors involving the prostatic urethra in men will be excluded
* A history of clinically significant polyuria with recorded 24-hour urine volumes greater than 4000 milliliters (mL)
* Indwelling catheters are not permitted; however, intermittent catheterization is acceptable
DETAILS
Bladder cancer is the tenth most common malignancy worldwide. About 75 percent (%) of bladder cancers are non-muscle invasive at diagnosis with approximately 25% of NMIBC patients have HR, NMIBC. The TAR-200/gemcitabine (JNJ-17000139) product is an intravesical drug delivery system regulated as an investigational drug. The drug constituent consists of gemcitabine and osmotic minitablets. Cetrelimab (JNJ-63723283) is a fully human immunoglobulin G4 (IgG4) kappa monoclonal antibody (mAb) that binds programmed-cell death protein (PD)-1. The mainstay of treatment for HR-NMIBC is transurethral resection of bladder tumor, followed by intravesical treatment with BCG. In this study metronomic dosing of intravesical gemcitabine, delivered via TAR-200, alone or in combination with cetrelimab will be evaluated and compared against intravesical BCG. The study consists of a Screening phase, Treatment phase, and Follow-up phase. The total duration of the study will be up to 5 years and 2 months. Efficacy, Safety, pharmacokinetics (PK), and biomarkers will be assessed at specific time points during the study.
LOCATIONS
| Country (21) | City or Province (241) | Status |
| United States | Ann Arbor, MI University of Michigan |
RECRUITING
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| United States | Atlanta, GA Grady Memorial Hospital |
RECRUITING
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| United States | Atlanta, GA The Emory Clinic Department of Urology |
RECRUITING
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| United States | Austin, TX Urology Austin |
RECRUITING
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| United States | Bala-Cynwyd, PA Centers for Advanced Urology LLC d b a MidLantic Urology |
RECRUITING
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| United States | Burlington, MA Lahey Hospital & Medical Center |
RECRUITING
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| United States | Camden, NJ Cooper Health System MD Anderson Cancer Center at Cooper |
RECRUITING
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| United States | Carmel, IN Urology of Indiana |
RECRUITING
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| United States | Chicago, IL Northwestern University |
RECRUITING
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| United States | Cleveland, OH Cleveland Clinic |
RECRUITING
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| United States | Dallas, TX Urology Clinics of North Texas |
RECRUITING
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| United States | Gahanna, OH Central Ohio Urology Group |
RECRUITING
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| United States | Greenville, NC Vidant Urology - Greenville |
RECRUITING
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| United States | Hanover, MD Chesapeake Urology Research Associates |
RECRUITING
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| United States | Hialeah, FL Urological Research Network |
RECRUITING
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| United States | Houston, TX Houston Methodist Hospital |
RECRUITING
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| United States | Houston, TX Houston Metro Urology |
RECRUITING
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| United States | Jeffersonville, IN First Urology |
RECRUITING
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| United States | Lakewood, CO Colorado Clinical Research |
RECRUITING
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| United States | Lisle, IL Duly Health and Care |
RECRUITING
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| United States | Little Rock, AR Arkansas Urology |
RECRUITING
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| United States | Long Beach, CA VA Long Beach Health Care System |
RECRUITING
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| United States | Los Alamitos, CA Genesis Research, LLC - West Coast Urology |
RECRUITING
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| United States | Los Angeles, CA Cedars Sinai Medical Center |
RECRUITING
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| United States | Merriam, KS AMR Kansas City Oncology |
RECRUITING
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| United States | Minneapolis, MN University Of Minnesota |
RECRUITING
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| United States | Myrtle Beach, SC Carolina Urologic Research Center |
RECRUITING
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| United States | Nashville, TN Urology Associates |
RECRUITING
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| United States | Nashville, TN Vanderbilt University Medical Center |
RECRUITING
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| United States | New York, NY Icahn School of Medicine at Mt. Sinai |
RECRUITING
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| United States | New York, NY VA NY Harbor Healthcare System |
RECRUITING
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| United States | Omaha, NE The Urology Center, PC |
RECRUITING
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| United States | Orlando, FL Orlando Health Cancer Institute |
COMPLETED
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| United States | Philadelphia, PA Thomas Jefferson University Hospital |
RECRUITING
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| United States | Pittsburgh, PA UPMC Shadyside Hospital |
RECRUITING
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| United States | Quincy, IL Blessing Hospital |
RECRUITING
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| United States | Rochester, MN Mayo Clinic Rochester |
RECRUITING
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| United States | Sacramento, CA UC Davis Comprehensive Cancer Center |
RECRUITING
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| United States | Salt Lake City, UT George E. Wahlen VAMC |
RECRUITING
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| United States | Salt Lake City, UT Huntsman Cancer Institute |
RECRUITING
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| United States | San Antonio, TX Urology San Antonio Research |
RECRUITING
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| United States | San Diego, CA Genesis Research |
RECRUITING
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| United States | Santa Monica, CA Providence Saint Johns Cancer Institute |
RECRUITING
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| United States | Santa Rosa, CA Providence Medical Foundation |
RECRUITING
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| United States | Sarasota, FL Sarasota Memorial Hospital |
RECRUITING
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| United States | Scottsdale, AZ Mayo Clinic |
RECRUITING
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| United States | Spokane, WA Spokane Urology |
ACTIVE_NOT_RECRUITING
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| United States | Syracuse, NY Associated Medical Professionals of Ny |
RECRUITING
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| United States | Syracuse, NY SUNY Upstate Med Univ |
RECRUITING
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| United States | Virginia Beach, VA Urology Of Virginia, Pllc |
ACTIVE_NOT_RECRUITING
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| United States | Wichita, KS Wichita Urology Group |
RECRUITING
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| United Kingdom | Edinburgh Western General Hospital |
ACTIVE_NOT_RECRUITING
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| United Kingdom | London Charing Cross Hospital |
ACTIVE_NOT_RECRUITING
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| United Kingdom | London St Bartholomews Hospital |
ACTIVE_NOT_RECRUITING
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| United Kingdom | London The Royal Marsden NHS Trust |
COMPLETED
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| United Kingdom | Plymouth Derriford Hospital |
ACTIVE_NOT_RECRUITING
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| United Kingdom | Scunthorpe Scunthorpe General Hospital |
ACTIVE_NOT_RECRUITING
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| United Kingdom | Sheffield, SYK Sheffield Teaching Hospitals NHS Foundation Trust |
ACTIVE_NOT_RECRUITING
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| United Kingdom | Stevenage, HRT Lister Hospital |
ACTIVE_NOT_RECRUITING
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| United Kingdom | Truro, CON Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital |
ACTIVE_NOT_RECRUITING
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| Taiwan | Kaohsiung Chang Kung Memorial Hospital |
ACTIVE_NOT_RECRUITING
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| Taiwan | Kaohsiung City Kaohsiung Medical University Chung Ho Memorial Hospital |
ACTIVE_NOT_RECRUITING
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| Taiwan | Taichung Taichung Veterans General Hospital |
ACTIVE_NOT_RECRUITING
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| Taiwan | Taichung City China Medical University Hospital |
COMPLETED
|
| Taiwan | Taipei Taipei Veterans General Hospital |
ACTIVE_NOT_RECRUITING
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| Taiwan | Taoyuan Linkou Chang Gung Memorial Hospital |
ACTIVE_NOT_RECRUITING
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| Spain | A Coruña Hosp. Univ. A Coruna |
ACTIVE_NOT_RECRUITING
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| Spain | Algeciras Hosp. Punta de Europa |
ACTIVE_NOT_RECRUITING
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| Spain | Barcelona, BA Fund. Puigvert |
ACTIVE_NOT_RECRUITING
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| Spain | Castellon Hosp. Gral. Univ. de Castellon |
ACTIVE_NOT_RECRUITING
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| Spain | Cádiz Hosp. Puerta Del Mar |
ACTIVE_NOT_RECRUITING
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| Spain | L'Hospitalet de Llobregat, BA Hosp. Univ. de Bellvitge |
ACTIVE_NOT_RECRUITING
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| Spain | Lugo, LG Hosp. Univ. Lucus Augusti |
ACTIVE_NOT_RECRUITING
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| Spain | Madrid, MD Clinica Univ. de Navarra |
ACTIVE_NOT_RECRUITING
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| Spain | Madrid, MD Hosp. Univ. 12 de Octubre |
ACTIVE_NOT_RECRUITING
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| Spain | Madrid, MD Hosp. Univ. La Paz |
ACTIVE_NOT_RECRUITING
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| Spain | Málaga Hosp Virgen de La Victoria |
ACTIVE_NOT_RECRUITING
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| Spain | Santander, CT Hosp. Univ. Marques de Valdecilla |
ACTIVE_NOT_RECRUITING
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| Spain | Valencia, VC Hosp. Clinico Univ. de Valencia |
ACTIVE_NOT_RECRUITING
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| South Korea | Busan Pusan National University Hospital |
ACTIVE_NOT_RECRUITING
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| South Korea | Cheongju, 43 Chungbuk National University Hospital |
ACTIVE_NOT_RECRUITING
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| South Korea | Daegu Keimyung University Dongsan Hospital |
ACTIVE_NOT_RECRUITING
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| South Korea | Daegu Kyungpook National University Chilgok Hospital |
ACTIVE_NOT_RECRUITING
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| South Korea | Gyeonggi-do, 41 National Cancer Center |
ACTIVE_NOT_RECRUITING
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| South Korea | Jeollanam-do, 46 Chonnam National University Hwasun Hospital |
ACTIVE_NOT_RECRUITING
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| South Korea | Seoul Kangbuk Samsung Hospital |
ACTIVE_NOT_RECRUITING
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| South Korea | Seoul Korea University Anam Hospital |
ACTIVE_NOT_RECRUITING
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| South Korea | Seoul Samsung Medical Center |
ACTIVE_NOT_RECRUITING
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| South Korea | Seoul Seoul National University Hospital |
ACTIVE_NOT_RECRUITING
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| South Korea | Seoul Severance Hospital Yonsei University Health System |
ACTIVE_NOT_RECRUITING
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| South Korea | Seoul The Catholic University of Korea Seoul St Marys Hospital |
ACTIVE_NOT_RECRUITING
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| Portugal | Coimbra, Coimbra Instituto Portugues de Oncologia de Coimbra Francisco Gentil, EPE |
ACTIVE_NOT_RECRUITING
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| Portugal | Lisboa Centro Hospitalar de Lisboa Norte Hospital Santa Maria |
ACTIVE_NOT_RECRUITING
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| Portugal | Vila Nova de Gaia Centro Hospitalar de Vila Nova de Gaia Espinho E P E |
ACTIVE_NOT_RECRUITING
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| Poland | Bialystok Uniwersytecki Szpital Kliniczny w Bialymstoku |
ACTIVE_NOT_RECRUITING
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| Poland | Bydgoszcz IN VIVO Sp. z o.o |
ACTIVE_NOT_RECRUITING
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| Poland | Lublin Wojewodzki Szpital Specjalistyczny im. Stefana Kardynala Wyszynskiego SPZOZ |
COMPLETED
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| Poland | Piotrkow Trybunalski Centrum Medyczne |
ACTIVE_NOT_RECRUITING
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| Poland | Poznan Clinical Research Center sp z o o MEDIC R s k |
ACTIVE_NOT_RECRUITING
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| Poland | Slupsk Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka, |
ACTIVE_NOT_RECRUITING
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| Poland | Warszawa Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy |
ACTIVE_NOT_RECRUITING
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| Poland | Warszawa Provita Poliklinika |
ACTIVE_NOT_RECRUITING
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| Poland | Wroclaw Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu |
ACTIVE_NOT_RECRUITING
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| Netherlands | Hoofddorp Spaarne Ziekenhuis |
ACTIVE_NOT_RECRUITING
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| Netherlands | Nijmegen, GE Canisius-Wilhelmina Ziekenhuis |
ACTIVE_NOT_RECRUITING
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| Netherlands | Nijmegen, GE Radboud Umcn |
COMPLETED
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| Mexico | Ciudad de México Consultorio Medico dentro del Hospital Angeles Acoxpa |
RECRUITING
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| Mexico | Monterrey Avix Investigacion Clinica S C |
COMPLETED
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| Mexico | Monterrey Hospital Universitario Dr Jose Eleuterio Gonzalez |
ACTIVE_NOT_RECRUITING
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| Mexico | Mérida, YUC Eme Red Hospitalaria |
RECRUITING
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| Mexico | San Luis Potosí Oncologico Potosino |
ACTIVE_NOT_RECRUITING
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| Japan | Fuji-shi Fuji City General Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Kanazawa Kanazawa University Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Kashihara-shi, 29 Nara Medical University Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Kisarazu-shi Kimitsu Chuo Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Kobe City, 28 Kobe City Medical Center General Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Kumamoto-shi, 43 National Hospital Organization Kumamoto Medical Center |
ACTIVE_NOT_RECRUITING
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| Japan | Nagano-shi, 20 Nagano Municipal Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Nagasaki-Shi, 42 JRC Nagasaki Genbaku Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Nagasaki-shi, 42 Nagasaki University Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Narashino-shi Saiseikai Narashino Hospital |
COMPLETED
|
| Japan | Toon-shi, 38 Ehime University Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Toyama-shi, 16 Toyama University Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Ube Yamaguchi University Hospital |
ACTIVE_NOT_RECRUITING
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| Japan | Yokohama, 14 Yokohama City University Medical Center |
ACTIVE_NOT_RECRUITING
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| Italy | Acquaviva delle Fonti Generale Regionale F. Miulli |
RECRUITING
|
| Italy | Asti Ospedale Cardinal Massaia |
RECRUITING
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| Italy | Avellino Ospedale San Giuseppe Moscati di Avellino |
ACTIVE_NOT_RECRUITING
|
| Italy | Castelfranco Veneto Ospedale San Giacomo Apostolo, Guardia pediatrica territoriale |
ACTIVE_NOT_RECRUITING
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| Italy | Milano Istituto Dei Tumori Di Milano |
COMPLETED
|
| Italy | Milano Istituto Europeo di Oncologia |
COMPLETED
|
| Italy | Milano Ospedale San Raffaele di Milano |
RECRUITING
|
| Italy | Napoli Fondazione G Pascale Istituto Nazionale Tumori IRCCS |
ACTIVE_NOT_RECRUITING
|
| Italy | Ravenna Ospedale S. Maria Delle Croci |
COMPLETED
|
| Italy | Rome Istituto Nazionale Tumori Regina Elena |
ACTIVE_NOT_RECRUITING
|
| India | Bangalore, KA Health Care Global Enterprises pvt Ltd |
ACTIVE_NOT_RECRUITING
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| India | Chandigarh Post Graduate Institute of Medical Education And Research PGIMER |
ACTIVE_NOT_RECRUITING
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| India | Gurugram, HR Artemis Hospital |
ACTIVE_NOT_RECRUITING
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| India | Kolkata, WB Netaji Subhas chandra Bose Cancer Research Institute |
ACTIVE_NOT_RECRUITING
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| India | Mumbai, MH Tata Memorial Hospital |
ACTIVE_NOT_RECRUITING
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| India | Pune, MH CIMET s Inamdar Multispeciality Hospital |
ACTIVE_NOT_RECRUITING
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| Germany | Duisburg Urologicum Duisburg |
ACTIVE_NOT_RECRUITING
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| Germany | Erlangen Universitatsklinikum Erlangen |
ACTIVE_NOT_RECRUITING
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| Germany | Essen Universitatsklinikum Essen |
COMPLETED
|
| Germany | Frankfurt am Main, HE Universitaetsklinikum Frankfurt |
ACTIVE_NOT_RECRUITING
|
| Germany | Freiburg, BW Universitaetsklinikum Freiburg |
COMPLETED
|
| Germany | Köln Urologische Partnerschaft Koln UPK |
ACTIVE_NOT_RECRUITING
|
| Germany | Markkleeberg Matthias Schulze - Germany |
RECRUITING
|
| Germany | Mettmann, NW Urologie Neandertal Praxis Mettmann |
ACTIVE_NOT_RECRUITING
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| Germany | Muenster Universitatsklinikum Munster |
ACTIVE_NOT_RECRUITING
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| Germany | München Klinikum rechts der Isar an der Technischen Universitat Munchen |
ACTIVE_NOT_RECRUITING
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| Germany | Nuernberg Klinikum Nurnberg Nord |
ACTIVE_NOT_RECRUITING
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| Germany | Nurnberg, BY Medizinisches Versorgungszentrum - Urologie |
COMPLETED
|
| Germany | Nürtingen, BW Studienpraxis Urologie Nurtingen |
ACTIVE_NOT_RECRUITING
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| Germany | Regensburg Caritas-Krankenhaus St. Josef |
ACTIVE_NOT_RECRUITING
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| Germany | Tübingen, BW Universitat Tubingen |
ACTIVE_NOT_RECRUITING
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| France | Bordeaux Polyclinique Bordeaux Nord Acquitaine |
COMPLETED
|
| France | Clermont-Ferrand CHU Gabriel-Montpied |
COMPLETED
|
| France | Grenoble CHU Grenoble |
ACTIVE_NOT_RECRUITING
|
| France | Limoges Polyclinique de Limoges - Francois Chenieux |
ACTIVE_NOT_RECRUITING
|
| France | Lyon Hôpital Edouard Herriot |
ACTIVE_NOT_RECRUITING
|
| France | Nantes CHU de Nantes hotel Dieu |
ACTIVE_NOT_RECRUITING
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| France | Nimes CHU Nîmes |
ACTIVE_NOT_RECRUITING
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| France | Orléans Centre Hospitalier Regional d'Orleans (CHRO) - Hopital La Source |
ACTIVE_NOT_RECRUITING
|
| France | PARIS cedex 20 Groupe Hospitalier Diaconesses Croix Saint Simon |
ACTIVE_NOT_RECRUITING
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| France | Paris APHP - Hopital Bichat - Claude Bernard |
ACTIVE_NOT_RECRUITING
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| France | Paris Hopital Europeen Georges-Pompidou |
ACTIVE_NOT_RECRUITING
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| France | Paris Hôpital Universitaire Pitié-Salpêtrière |
ACTIVE_NOT_RECRUITING
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| France | Quint-Fonsegrives Clinical La Croix Du Sud - Ramsay Santé |
ACTIVE_NOT_RECRUITING
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| France | Rennes Chu Rennes Hopital Pontchaillou |
ACTIVE_NOT_RECRUITING
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| France | Strasbourg Institut de Cancerologie Strasbourg Europe ICANS |
RECRUITING
|
| France | Toulouse CHU Rangueil |
ACTIVE_NOT_RECRUITING
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| Czechia | Brno Fakultni nemocnice u sv. Anny v Brne |
ACTIVE_NOT_RECRUITING
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| Czechia | Hradec Králové Fakultni nemocnice Hradec Kralove |
ACTIVE_NOT_RECRUITING
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| Czechia | Liberec Krajská nemocnice Liberec a.s. |
ACTIVE_NOT_RECRUITING
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| Czechia | Olomouc Fakultni nemocnice Olomouc |
ACTIVE_NOT_RECRUITING
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| Czechia | Prague Fakultni nemocnice v Motole |
ACTIVE_NOT_RECRUITING
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| Czechia | Praha Fakultni nemocnice Kralovske Vinohrady |
ACTIVE_NOT_RECRUITING
|
| Czechia | Praha 4 Thomayerova nemocnice, Onkologicka klinika |
ACTIVE_NOT_RECRUITING
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| China | Beijing, 11 Beijing Hospital |
RECRUITING
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| China | Beijing, 11 Beijing Luhe Hospital, Capital Medical University |
RECRUITING
|
| China | Beijing, 11 Peking University First Hospital |
RECRUITING
|
| China | Chang Sha Hunan Province Cancer Hospital |
ACTIVE_NOT_RECRUITING
|
| China | Changchun The First Bethune Hospital of Jilin University |
RECRUITING
|
| China | Chengdu West China Hospital Sichuan University |
RECRUITING
|
| China | Chongqing, 97 Chongqing University Cancer Hospital |
RECRUITING
|
| China | Deyang City People's Hospital of Deyang City |
RECRUITING
|
| China | GuangZhou Sun Yat-Sen University Cancer Center |
RECRUITING
|
| China | Hangzhou Sir Run Run Shaw Hospital, Zhejiang University School of Medicine |
RECRUITING
|
| China | Hangzhou Zhejiang Provincial People's Hospital |
COMPLETED
|
| China | Nanjing Nanjing Drum Tower Hospital |
ACTIVE_NOT_RECRUITING
|
| China | Ningbo The First Affiliated Hospital of Ningbo University |
RECRUITING
|
| China | Shanghai, 31 Huadong Hospital Affiliated to Fudan University |
ACTIVE_NOT_RECRUITING
|
| China | Shanghai, 31 Ruijing Hospital Affiliated To Shanghai Jiaotong University School Of Medicine |
ACTIVE_NOT_RECRUITING
|
| China | Shenyang Shengjing Hospital Of China Medical University |
RECRUITING
|
| China | Tianjin, 12 The Second Hospital Of Tianjin Medical University |
RECRUITING
|
| China | Wenzhou The First Affiliated Hospital of Wenzhou Medical University |
ACTIVE_NOT_RECRUITING
|
| China | Wuhan TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology |
ACTIVE_NOT_RECRUITING
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| China | Xian First Affiliated Hospital of Medical College of Xi'an Jiaotong University |
RECRUITING
|
| China | Yantai Yantai Yuhuangding Hospital |
RECRUITING
|
| China | Zhengzhou Henan Cancer Hospital |
RECRUITING
|
| Canada | Halifax, NS Nova Scotia Health Authority |
ACTIVE_NOT_RECRUITING
|
| Canada | Hamilton, ON St Josephs Healthcare Hamilton |
ACTIVE_NOT_RECRUITING
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| Canada | Montréal, QC CHUM - Centre hospitalier universitaire de Montreal |
RECRUITING
|
| Canada | Quebec, QC CHU de Quebec Universite Laval Hopital de l Enfant Jesus |
ACTIVE_NOT_RECRUITING
|
| Canada | Saint Jerome Quebec, QC Unite de Recherche Clinique du CISSS des Laurentides |
COMPLETED
|
| Canada | Toronto, ON Princess Margaret Cancer Centre University Health Network |
ACTIVE_NOT_RECRUITING
|
| Brazil | Barretos, SP Fundacao Pio XII |
RECRUITING
|
| Brazil | Bauru, SP NAIC Nair Antunes Instituto do Cancer |
RECRUITING
|
| Brazil | Campinas, SP Universidade Estadual De Campinas |
RECRUITING
|
| Brazil | Curitiba, PR Liga Paranaense de Combate ao Cancer |
RECRUITING
|
| Brazil | Natal, RN Liga Norte Riograndense Contra O Cancer |
RECRUITING
|
| Brazil | Porto Alegre, RS Irmandade Santa Casa de Misericordia de Porto Alegre |
RECRUITING
|
| Brazil | Presidente Prudente, SP Hospital Regional do Cancer - Hospital de Esperança |
RECRUITING
|
| Brazil | Salvador, BA Hospital Sao Rafael |
RECRUITING
|
| Brazil | Santa Cruz Do Sul, RS Hospital Ana Nery Santa Cruz do Sul |
RECRUITING
|
| Brazil | Santo Andre, SP CEPHO - Centro de Estudos e Pesquisa de Hematologia e Oncologia |
RECRUITING
|
| Brazil | Sao Paulo, SP Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo |
RECRUITING
|
| Brazil | Sao Paulo, SP Real e Benemérita Associação Portuguesa de Beneficência |
RECRUITING
|
| Brazil | São Paulo, SP Fundacao Antonio Prudente A C Camargo Cancer Center |
ACTIVE_NOT_RECRUITING
|
| Brazil | São Paulo, SP Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein |
RECRUITING
|
| Belgium | Antwerpen ZNA Middelheim |
RECRUITING
|
| Belgium | Brugge AZ Sint-Jan |
ACTIVE_NOT_RECRUITING
|
| Belgium | Brugge AZ Sint-Lucas |
ACTIVE_NOT_RECRUITING
|
| Belgium | Gent AZ Maria Middelares |
ACTIVE_NOT_RECRUITING
|
| Belgium | Gent UZ Gent |
ACTIVE_NOT_RECRUITING
|
| Belgium | Libramont-Chevigny, WLX Centre Hospitalier de l'Ardenne |
ACTIVE_NOT_RECRUITING
|
| Belgium | Roeselare AZ Delta |
ACTIVE_NOT_RECRUITING
|
| Belgium | Sint-Niklaas Vitaz |
ACTIVE_NOT_RECRUITING
|
| Belgium | Wilrijk GZA Ziekenhuizen- Campus St Augustinus |
ACTIVE_NOT_RECRUITING
|
| Australia | Heidelberg, VIC Austin Health |
ACTIVE_NOT_RECRUITING
|
| Australia | Macquarie University Macquarie University Hospital |
RECRUITING
|
| Australia | Nedlands, WA Hollywood Private Hospital |
ACTIVE_NOT_RECRUITING
|
| Australia | South Brisbane, QLD Mater Hospital Brisbane |
COMPLETED
|
| Argentina | Buenos Aires, B Hospital Italiano de Buenos Aires |
RECRUITING
|
| Argentina | Buenos Aires, B Sociedade Beneficente de Senhoras - Hospital Sírio Libanês |
RECRUITING
|
| Argentina | Cordoba Centro Urologico Profesor Bengio |
RECRUITING
|
| Argentina | Cordoba Hospital Privado - Centro Medico de Cordoba |
RECRUITING
|
| Argentina | Córdoba, X Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica |
RECRUITING
|
| Argentina | Mar del Plata Hospital Privado de la Comunidad |
RECRUITING
|
| Argentina | Rio Cuarto Instituto Medico Rio Cuarto |
RECRUITING
|
Indicates 50+ sites in this region: click to zoom in.
Indicates 10+ sites in this region: click to zoom in.
Indicates < 10 sites in this region: click to zoom in.
Corresponds to individual site.