A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma (MajesTEC-7)
Last Updated April 11, 2025
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CR109237
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 33 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to compare the efficacy of teclistamab in combination with daratumumab and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab and lenalidomide (Tal-DR) versus daratumumab, lenalidomide, dexamethasone (DRd).
CONDITIONS
- Multiple Myeloma
ELIGIBILITY
Inclusion Criteria:
* Have a diagnosis of multiple myeloma according to the International Myeloma Working Group (IMWG) diagnostic criteria
* Be newly diagnosed and not considered a candidate for high-dose chemotherapy with autologous stem cell transplant (ASCT) due to: ineligible
DETAILS
LOCATIONS
Locations in:
Australia, Austria, Belgium, Brazil, China, Czechia, Denmark, France, Germany, Greece, Israel, Italy, Japan, South Korea, Netherlands, Norway, Poland, Portugal, Spain, Sweden, Switzerland, Türkiye, United Kingdom, Canada, United States
| Country (25) | City or Province (199) | Status |
| Australia | Camperdown Royal Prince Alfred Hospital |
RECRUITING
|
| Australia | Geelong Barwon Health - University Hospital Geelong |
RECRUITING
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| Australia | Liverpool Liverpool Hospital |
RECRUITING
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| Australia | New South Wales Calvary Mater Newcastle Hospital |
RECRUITING
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| Australia | Wollongong Wollongong Hospital |
RECRUITING
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| Australia | Woolloongabba Princess Alexandra Hospital |
RECRUITING
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| Austria | Linz Ordensklinikum Linz GmbH Elisabethinen |
RECRUITING
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| Austria | Salzburg SCRI CCCIT gem GmbH |
RECRUITING
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| Belgium | Anderlecht Institut Jules Bordet |
RECRUITING
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| Belgium | Gent Ghent University Hospital |
RECRUITING
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| Belgium | Haine Saint Paul La Louviere Jolimont |
COMPLETED
|
| Belgium | Kortrijk Az Groeninge |
RECRUITING
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| Belgium | Leuven Universitair Ziekenhuis Leuven |
RECRUITING
|
| Belgium | Wilrijk GZA Ziekenhuizen- Campus St Augustinus |
COMPLETED
|
| Brazil | Belo Horizonte Santa Casa de Misericordia de Belo Horizonte |
RECRUITING
|
| Brazil | Fortaleza Instituto Do Cancer Do Ceara |
RECRUITING
|
| Brazil | Natal Liga Norte Riograndense Contra O Cancer |
RECRUITING
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| Brazil | Niteroi Complexo Hospitalar de Niteroi |
RECRUITING
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| Brazil | Ribeirao Preto Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP |
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| Brazil | Salvador Hospital Sao Rafael |
RECRUITING
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| Brazil | Sao Paulo Clinica Medica Sao Germano S/S LTDA |
RECRUITING
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| China | Beijing Peking University First Hospital |
RECRUITING
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| China | Changsha The Second Xiangya Hospital of Central South Hospital |
RECRUITING
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| China | Fu Zhou Fujian Meidical University Union Hospital |
RECRUITING
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| China | Guangzhou Sun Yat -Sen University Cancer Center |
RECRUITING
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| China | Jinan Qilu Hospital of Shandong University |
RECRUITING
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| China | Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine |
RECRUITING
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| China | Shanghai Shanghai Fourth People s Hospital |
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| China | Tian Jin Institute of Hematology and Blood Diseases Hospital |
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| China | Tianjin Tianjin Medical University Cancer Institute and Hospital |
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| China | Wenzhou The First Affiliated Hospital of Wenzhou Medical University |
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| China | WuHan Wuhan Tongji Hospital Tongji Medical College |
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| Czechia | Brno - Bohunice Fakultni nemocnice Brno |
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| Czechia | Hradec Kralove Fakultni nemocnice Hradec Kralove |
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| Czechia | Olomouc Fakultni nemocnice Olomouc |
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|
| Czechia | Ostrava Fakultni Nemocnice Ostrava |
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| Czechia | Plzen Fakultni nemocnice Plzen |
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| Czechia | Praha VFN v Praze |
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|
| Denmark | Vejle Vejle Sygehus |
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|
| France | Creteil APHP - Hopital Henri Mondor |
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| France | Lille Hopital Claude Huriez |
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| France | Nantes CHU Nantes |
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| France | PARIS cedex 12 CHU Hopital Saint Antoine |
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| France | Pessac cedex CHU de Bordeaux - Hospital Haut-Leveque |
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| France | Pierre-Benite CHU Lyon Sud |
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| France | Poitiers CHU Poitiers - Hopital la Miletrie |
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| France | Rennes CHU de Rennes - Hopital Pontchaillou |
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| France | Strasbourg Institut de Cancerologie Strasbourg Europe ICANS |
RECRUITING
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| France | Toulouse Institut Universitaire du Cancer Toulouse Oncopole |
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| Germany | Berlin Helios Kliniken Berlin Buch Gmbh |
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| Germany | Halle (Saale) Universitaetsklinikum Halle Saale |
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| Germany | Hamburg Universitaetsklinik Hamburg-Eppendorf |
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| Germany | Nuernberg Klinikum Nuernberg Nord |
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| Germany | Tübingen Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II, |
RECRUITING
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| Germany | Wurzburg Universitaetsklinikum Wuerzburg |
RECRUITING
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| Greece | Athens Attica Alexandra General Hospital of Athens |
RECRUITING
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| Greece | Thessalonikis G Papanikolaou Hospital of Thessaloniki |
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| Greece | Thessaloniki Anticancer Hospital of Thessaloniki Theageneio |
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| Israel | Haifa Rambam Medical Center |
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| Israel | Petah Tikva Rabin |
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| Israel | Ramat Gan Sheba Medical Center |
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| Israel | Tel Aviv Yafo Tel Aviv Sourasky Medical Center |
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| Italy | Bologna A O U Sant Orsola Malpighi |
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| Italy | Firenze Careggi University Hospital |
RECRUITING
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| Italy | Milan Ospedale San Raffaele |
RECRUITING
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| Italy | Pavia IRCCS Policlinico San Matteo, Università degli studi di Pavi |
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| Italy | Roma Universita Degli Studi di Roma Tor Vergata |
RECRUITING
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| Italy | Rozzano Istituto Clinico Humanitas |
RECRUITING
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| Italy | Torino Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino |
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| Japan | Chiba Kameda Medical Center |
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| Japan | Higashiibaraki-gun National Hospital Organization Mito Medical Center |
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| Japan | Hirakata Kansai Medical University Hospital |
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| Japan | Iruma-gun Saitama Medical University Hospital |
RECRUITING
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| Japan | Matsuyama-City Matsuyama Red Cross Hospital |
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| Japan | Okayama National Hospital Organization Okayama Medical Center |
RECRUITING
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| Japan | Shibukawa National Hospital Organization Shibukawa Medical Center |
RECRUITING
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| Japan | Yamanashi Yamanashi Prefectural Central Hospital |
RECRUITING
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| South Korea | Busan Dong-A University Hospital |
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| South Korea | Busan Pusan National University Hospital |
RECRUITING
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| South Korea | Goyang si National Cancer Center |
RECRUITING
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| South Korea | Hwasun Chonnam National University Hwasun Hospital |
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| South Korea | Incheon Gachon University Gil Medical Center |
RECRUITING
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| South Korea | Seoul Seoul National University Hospital |
RECRUITING
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| South Korea | Seoul Severance Hospital Yonsei University Health System |
RECRUITING
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| South Korea | Seoul Asan Medical Center |
RECRUITING
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| South Korea | Seoul Samsung Medical Center |
RECRUITING
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| South Korea | Seoul The Catholic University of Korea Seoul St Mary s Hospital |
RECRUITING
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| Netherlands | Amsterdam VUMC Amsterdam |
RECRUITING
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| Netherlands | Apeldoorn Gelre Ziekenhuis |
RECRUITING
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| Netherlands | Nieuwegein St. Antonius Ziekenhuis Nieuwegein |
RECRUITING
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| Netherlands | Sittard-Geleen Zuyderland Medical Center |
RECRUITING
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| Norway | Oslo Oslo University Hospital HF Ulleval sykehus |
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| Norway | Trondheim St. Olavs Hospital |
RECRUITING
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| Poland | Brzozow Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza |
RECRUITING
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| Portugal | Lisbon Champalimaud Foundation Champalimaud Centre |
RECRUITING
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| Portugal | Porto Uls Hosp Sao Joao |
RECRUITING
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| Spain | Badalona Hosp. Univ. Germans Trias I Pujol |
RECRUITING
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| Spain | Barcelona Hosp. de La Santa Creu I Sant Pau |
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| Spain | Barcelona Hosp Univ Vall D Hebron |
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| Spain | Granada Hosp. Univ. Virgen de Las Nieves |
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| Spain | Jerez de la Frontera Hosp. de Jerez de La Frontera |
RECRUITING
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| Spain | Madrid Hosp. Univ. 12 de Octubre |
RECRUITING
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| Spain | Madrid Hosp. Univ. La Paz |
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| Spain | Madrid Hosp Univ Hm Sanchinarro |
RECRUITING
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| Spain | Palma de Mallorca Hosp. Univ. Son Espases |
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| Spain | Salamanca Hosp Clinico Univ de Salamanca |
RECRUITING
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| Spain | Terrassa Hosp. Mutua Terrassa |
RECRUITING
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| Spain | Valencia Hosp. Clinico Univ. de Valencia |
RECRUITING
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| Sweden | Falun Falu Lasarett |
RECRUITING
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| Sweden | Lund Skanes universitetssjukhus |
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| Sweden | Stockholm Karolinska University Hospital Huddinge |
RECRUITING
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| Sweden | Örebro Universitetssjukhuset Orebro |
RECRUITING
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| Switzerland | St. Gallen Kantonsspital St Gallen |
RECRUITING
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| Türkiye | Ankara Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital |
RECRUITING
|
| Türkiye | Ankara Ankara University Medical Faculty |
RECRUITING
|
| Türkiye | Ankara Liv Hospital Ankara |
RECRUITING
|
| Türkiye | Istanbul Medipol University Hospital |
RECRUITING
|
| Türkiye | Izmir Dokuz Eylul University Medical Faculty |
COMPLETED
|
| Türkiye | Samsun Ondokuz Mayis University |
RECRUITING
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| United Kingdom | Blackpool Blackpool Victoria Hospital |
RECRUITING
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| United Kingdom | Canterbury Kent and Canterbury Hospital |
RECRUITING
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| United Kingdom | Edinburgh Western General Hospital |
RECRUITING
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| United Kingdom | London Imperial College Healthcare |
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| Australia | Nedlands Sir Charles Gairdner Hospital |
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| Brazil | Sao Paulo Hospital Nove de Julho |
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| Canada | Quebec CHU de Quebec L Hotel Dieu de Quebec |
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| China | Chang Zhou Changzhou No 2 Peoples Hospital |
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| China | Changchun The First Hospital of Jilin University |
RECRUITING
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| China | Chaoyang District Beijing Chaoyang Hospital |
RECRUITING
|
| China | Harbin Harbin medical university cancer hospital |
RECRUITING
|
| China | Nan Jing Zhongda Hospital Southeast University |
RECRUITING
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| China | Nan Ning Shi The First Affiliated Hospital of Guangxi Medical University |
RECRUITING
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| China | Nanchang The First Affliated Hospital Of Nanchang University |
RECRUITING
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| China | Shanghai Ruijin Hospital Shanghai Jiao Tong University |
RECRUITING
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| China | Shenyang Shengjing Hospital Of China Medical University |
RECRUITING
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| Israel | Jerusalem Shaare Zedek Medical Center |
RECRUITING
|
| Japan | Chiba Chiba Cancer Center |
RECRUITING
|
| Japan | Hyôgo Hyogo Medical University Hospital |
RECRUITING
|
| Japan | Kanagawa Tokai University Hospital |
RECRUITING
|
| Japan | Kumamoto-shi Kumamoto University Hospital |
RECRUITING
|
| Japan | Nagasaki National Hospital Organization Nagasaki Medical Center |
RECRUITING
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| Japan | Osaka Osaka Metropolitan University Hospital |
RECRUITING
|
| Netherlands | Delft Reinier de Graaf Gasthuis |
RECRUITING
|
| Poland | Katowice Pratia Onkologia Katowice |
RECRUITING
|
| Spain | Pozuelo de Alarcon Hosp. Quiron Madrid Pozuelo |
RECRUITING
|
| United Kingdom | Bristol University Hospitals Bristol and Weston |
RECRUITING
|
| United States | Des Moines Mission Cancer Blood |
RECRUITING
|
| United States | Grand Rapids Cancer And Hematology Centers of Western Michigan PC |
RECRUITING
|
| United States | Omaha University of Nebraska Medical Center |
RECRUITING
|
| United States | Durham Durham VAMC |
RECRUITING
|
| Austria | Vienna Medical University Vienna |
RECRUITING
|
| Austria | Wien Hanusch Krankenhaus |
RECRUITING
|
| Brazil | Barretos Fundacao Pio XII |
RECRUITING
|
| Brazil | Curitiba Liga Paranaense de Combate ao Cancer |
RECRUITING
|
| Brazil | Porto Alegre Hospital De Clinicas De Porto Alegre |
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|
| Brazil | Sao Paulo Hospital Das Clinicas Da Faculdade De Medicina Da USP |
RECRUITING
|
| Canada | Calgary Arthur J E Child Comprehensive Cancer Centre |
RECRUITING
|
| Canada | Edmonton Cross Cancer Institute |
RECRUITING
|
| Canada | Vancouver British Columbia Cancer Agency |
RECRUITING
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| China | Beijing Peking Union Medical College Hospital |
RECRUITING
|
| China | Beijing Beijing Tongren Hospital CMU |
RECRUITING
|
| China | Chengdu Sichuan Provincial Peoples Hospital |
RECRUITING
|
| China | Chongqing Chongqing University Cancer Hospital |
RECRUITING
|
| China | Guangzhou Nanfang Hospital |
RECRUITING
|
| China | Hang Zhou The Second Affiliated Hospital of Zhejiang University |
RECRUITING
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| China | Hangzhou No.1 Affiliated Hospital, Medical College of Zhejiang University |
RECRUITING
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| China | Nanjing Nanjing Drum Tower Hospital |
RECRUITING
|
| China | Shen Zhen Shi Peking University Shenzhen Hospital |
RECRUITING
|
| China | Xi' An The Second Affiliated Hospital of Xi'an Jiaotong University |
RECRUITING
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| China | Xiamen The first affiliated hospital of xiamen university |
RECRUITING
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| China | Zhengzhou Henan Cancer Hospital |
RECRUITING
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| Denmark | Aalborg Aalborg University Hospital |
RECRUITING
|
| Denmark | Herning Regionshospitalet Godstrup |
RECRUITING
|
| Denmark | Roskilde Zealand University Hospital |
RECRUITING
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| Italy | Bergamo ASST Papa Giovanni XXIII Bergamo |
RECRUITING
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| Italy | Naples Azienda Ospedaliera di Rilievo Nazionale A Cardarelli |
RECRUITING
|
| Japan | Bunkyo Ku Juntendo University Hospital |
RECRUITING
|
| Japan | Kanazawa Kanazawa University Hospital |
RECRUITING
|
| Japan | Sapporo National Hospital Organization Hokkaido Cancer Center |
RECRUITING
|
| Japan | Shibuya-ku Japanese Red Cross Medical Center |
RECRUITING
|
| Japan | Sunto Gun Shizuoka Cancer Center |
RECRUITING
|
| Japan | Toyoake Fujita Health University Hospital |
RECRUITING
|
| Japan | Yamagata Yamagata University Hospital |
RECRUITING
|
| South Korea | Daegu Kyungpook National University Hospital |
RECRUITING
|
| Poland | Biala Podlaska Wojewodzki Szpital Kliniczny w Bialej Podlaskiej |
RECRUITING
|
| Poland | Bydgoszcz Szpital Uniwersytecki nr 2 im. Jana Biziela w Bydgoszczy |
RECRUITING
|
| Poland | Kielce Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach |
RECRUITING
|
| Poland | Lodz Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi |
RECRUITING
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| Poland | Lublin Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli |
RECRUITING
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| Poland | Poznan Uniwersytecki Szpital Kliniczny w Poznaniu |
RECRUITING
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| Poland | Zielona Gora Szpital Uniwersytecki im Karola Marcinkowskiego w Zielonej Gorze |
RECRUITING
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| Portugal | Braga Uls Braga - Hosp. Braga |
RECRUITING
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| Portugal | Porto Instituto Portugues de Oncologia |
RECRUITING
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| Switzerland | Bern Inselspital Universitatsspital Bern |
RECRUITING
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| Türkiye | Antalya Memorial Antalya Hospital |
RECRUITING
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| Türkiye | Denizli Pamukkale University Medical Faculty |
COMPLETED
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| United Kingdom | Cambridge Addenbrooke's Hospital |
RECRUITING
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| United Kingdom | London University College London Hospitals |
RECRUITING
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| United Kingdom | Wolverhampton New Cross Hospital |
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Geo Locations
-33.88965, 151.17642
-38.14711, 144.36069
-33.90011, 150.93328
-32.9025199, 151.7210265
-34.424, 150.89345
-27.48855, 153.03655
48.30639, 14.28611
47.79941, 13.04399
50.83619, 4.31454
51.05, 3.71667
50.45313, 4.19126
50.82803, 3.26487
50.87959, 4.70093
51.16734, 4.39513
-19.92083, -43.93778
-3.71722, -38.54306
-5.795, -35.20944
-22.88333, -43.10361
-21.1775, -47.81028
-12.97111, -38.51083
-23.5475, -46.63611
39.9075, 116.39723
28.19874, 112.97087
26.0855999, 119.307
23.11667, 113.25
36.66833, 116.99722
31.22222, 121.45806
31.22222, 121.45806
39.1251999, 117.191
39.14222, 117.17667
27.99942, 120.66682
30.58333, 114.26667
49.1693374, 16.5792118
50.20923, 15.83277
49.59552, 17.25175
49.83465, 18.28204
49.74747, 13.37759
50.08804, 14.42076
55.70927, 9.5357
48.78333, 2.46667
50.63297, 3.05858
47.21725, -1.55336
48.85341, 2.3488
44.81011, -0.64129
45.7009, 4.82511
46.58333, 0.33333
48.11198, -1.67429
48.58392, 7.74553
43.60426, 1.44367
52.52437, 13.41053
51.48159, 11.97948
53.57532, 10.01534
49.45421, 11.07752
48.52266, 9.05222
49.79391, 9.95121
37.9804964, 23.7561153
40.6455525, 23.0118975
40.64361, 22.93086
32.81841, 34.9885
32.08707, 34.88747
32.08227, 34.81065
32.08088, 34.78057
44.49381, 11.33875
43.77925, 11.24626
45.46427, 9.18951
45.19205, 9.15917
41.89193, 12.51133
45.38193, 9.1559
45.07049, 7.68682
35.6, 140.11667
36.325312, 140.4099602
34.81352, 135.64914
35.9395823, 139.3050206
33.83916, 132.76574
34.65, 133.93333
36.48333, 139
35.6709649, 138.5507574
35.10278, 129.04028
35.10278, 129.04028
37.65639, 126.835
35.06125, 126.98746
37.45646, 126.70515
37.566, 126.9784
37.566, 126.9784
37.566, 126.9784
37.566, 126.9784
37.566, 126.9784
52.37403, 4.88969
52.21, 5.96944
52.02917, 5.08056
50.9829825, 5.8450905
59.91273, 10.74609
63.43049, 10.39506
49.69501, 22.01926
38.71667, -9.13333
41.14961, -8.61099
41.45004, 2.24741
41.38879, 2.15899
41.38879, 2.15899
37.18817, -3.60667
36.68645, -6.13606
40.4165, -3.70256
40.4165, -3.70256
40.4165, -3.70256
39.56939, 2.65024
40.96882, -5.66388
41.56667, 2.01667
39.46975, -0.37739
60.60357, 15.62597
55.70584, 13.19321
59.33258, 18.0649
59.27412, 15.2066
47.42391, 9.37477
39.91987, 32.85427
39.91987, 32.85427
39.91987, 32.85427
41.01384, 28.94966
38.41273, 27.13838
41.27976, 36.3361
53.81667, -3.05
51.27904, 1.07992
55.95206, -3.19648
51.50853, -0.12574
-31.98184, 115.8073
-23.5475, -46.63611
46.81228, -71.21454
31.7610799, 119.97121
43.88, 125.32278
39.9157999, 116.453
45.75, 126.65
32.0583799, 118.79647
22.7975999, 108.361
28.68396, 115.85306
31.22222, 121.45806
41.79222, 123.43278
31.76904, 35.21633
35.6, 140.11667
34.7186409, 135.3791966
37.58333, 139.91667
32.80589, 130.69182
32.75, 129.88333
34.69374, 135.50218
52.00667, 4.35556
50.25841, 19.02754
40.43293, -3.81338
51.45523, -2.59665
41.60054, -93.60911
42.96336, -85.66809
41.25626, -95.94043
35.99403, -78.89862
48.20849, 16.37208
48.20849, 16.37208
-20.55722, -48.56778
-25.42778, -49.27306
-30.03306, -51.23
-23.5475, -46.63611
51.05011, -114.08529
53.55014, -113.46871
49.24966, -123.11934
39.9075, 116.39723
39.9075, 116.39723
30.66667, 104.06667
29.56278, 106.55278
23.11667, 113.25
30.2639399, 120.18035
30.29365, 120.16142
32.06167, 118.77778
22.5615299, 114.05462
34.2608999, 108.955
24.47979, 118.08187
34.75778, 113.64861
57.048, 9.9187
56.13932, 8.97378
55.64152, 12.08035
45.69601, 9.66721
40.85216, 14.26811
35.37517, 139.92991
36.6, 136.61667
43.06667, 141.35
35.469, 140.29807
35.1565356, 138.8845111
35.038, 136.99931
38.23333, 140.36667
35.87028, 128.59111
52.03238, 23.11652
53.1235, 18.00762
50.87033, 20.62752
51.75, 19.46667
51.25, 22.56667
52.40692, 16.92993
51.93548, 15.50643
41.55032, -8.42005
41.14961, -8.61099
46.94809, 7.44744
36.90812, 30.69556
37.77417, 29.0875
52.2, 0.11667
51.50853, -0.12574
52.58547, -2.12296
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