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My Saved Trials

A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (MajesTEC-9)

Last Updated   April 4, 2025

Want to learn how to participate in this trial?

CR109244

OVERVIEW

  • Sexes Eligible for Study
    all
  • Age
    18+ years
  • Phase
    phase 3
    3
  • Sites
    208 Sites
  • Status
    Recruiting

SUMMARY

The purpose of this study is to compare the efficacy of teclistamab with PVd/Kd in Part 1 and to further characterize safety and efficacy of an alternative dosing for teclistamab in Part 2 in participants with relapsed or refractory multiple myeloma.

CONDITIONS

  • Relapsed or Refractory Multiple Myeloma

ELIGIBILITY


Inclusion Criteria:

* Documented diagnosis of multiple myeloma as defined by the criteria below: (a)Multiple myeloma diagnosis according to International Myeloma Working Group (IMWG) diagnostic criteria (b) Measurable disease at screening as defined by any of the following: (1) Serum M-protein level greater than or equal to (>=)0.5 grams per deciliter (g/dL) (central laboratory); or (2) Urine M-protein level >=200 milligrams (mg)/24 hours (central laboratory); or (3) Serum immunoglobulin free light chain >=10 milligrams per deciliter (mg/dL) (central laboratory) and abnormal serum immunoglobulin kappa lambda free light chain ratio
* Received 1 to 3 prior lines of antimyeloma therapy including a minimum of 2 consecutive cycles of an anti- cluster of differentiation 38 (CD38) monoclonal antibody at the approved dosing regimen in any prior line and 2 consecutive cycles of lenalidomide in any prior line
* Documented evidence of progressive disease or failure to achieve a response to last line of therapy based on investigator's determination of response by International myeloma working group (IMWG) criteria
* Have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2
* A female participant must agree not to be pregnant, breast-feeding, or plan to become pregnant while enrolled in this study or within 6 months after the last dose of study treatment
* Must be willing and able to adhere to the lifestyle restrictions specified in this protocol


Exclusion Criteria:

* Received any prior B cell maturation antigen (BCMA)-directed therapy
* A participant is not eligible to receive PVd as control therapy if any of the following are present: (1) Received prior pomalidomide therapy, (2) Does not meet criteria for bortezomib retreatment (3) Contraindications or life-threatening allergies, hypersensitivity, or intolerance to pomalidomide or bortezomib, (4) Grade 1 peripheral neuropathy with pain or Grade greater than or equal to (>=) 2 peripheral neuropathy as defined by National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) Version 5.0, (5) Received a strong cytochrome P (CYP) 3A4 inducer within 5 half-lives prior to randomization; A participant is not eligible to receive Kd as control therapy if any of the following are present:(1) Received prior carfilzomib therapy, (2) Uncontrolled hypertension, defined as an average systolic blood pressure greater than (>)159 millimeters of mercury (mmHg) or diastolic blood pressure >99 mmHg despite optimal treatment (3) Grade 2 peripheral neuropathy with pain or Grade >=3 peripheral neuropathy as defined by NCI-CTCAE Version 5.0, (4) Contraindications or life-threatening allergies, hypersensitivity, or intolerance to carfilzomib (intolerance defined as prior therapy discontinued due to any adverse event [AE] related to carfilzomib)
* Received a maximum cumulative dose of corticosteroids of >=140 mg of prednisone or equivalent within 14 days prior to randomization
* Received a live, attenuated vaccine within 4 weeks before randomization
* Central nervous system (CNS) involvement or clinical signs of meningeal involvement of multiple myeloma
* Plasma cell leukemia at the time of screening, Waldenstrom's macroglobulinemia, polyneuropathy, organomegaly, endocrinopathy, M-protein (POEMS) syndrome and skin changes, or primary amyloid light chain amyloidosis


Inclusion Criteria:

* Documented diagnosis of multiple myeloma as defined by the criteria below: (a)Multiple myeloma diagnosis according to International Myeloma Working Group (IMWG) diagnostic criteria (b) Measurable disease at screening as defined by any of the following: (1) Seru

More...

DETAILS

LOCATIONS

Locations in:
United States, Australia, Austria, Belgium, Brazil, Canada, China, Czechia, Denmark, France, Germany, Greece, India, Israel, Italy, Japan, Malaysia, Netherlands, Poland, Portugal, Spain, Sweden, Türkiye, United Kingdom
Country (24) City or Province (208) Status
United States Anchorage Alaska Oncology and Hematology LLC
COMPLETED
United States Berkeley Alta Bates Comprehensive Cancer Center
RECRUITING
United States Long Beach MemorialCare Long Beach Medical Center
RECRUITING
United States Orange University of California Irvine
RECRUITING
United States Whittier PIH Health Hospital
RECRUITING
United States Farmington University of Connecticut
RECRUITING
United States Miami University of Miami Sylvester Cancer Center
RECRUITING
United States Orlando Orlando Health Cancer Institute
RECRUITING
United States Weston Cleveland Clinic Florida
RECRUITING
United States Boston Boston University Medical Center
RECRUITING
United States Camden Cooper Health System MD Anderson Cancer Center at Cooper
RECRUITING
United States New York Herbert Irving Comprehensive Cancer Center Columbia University Medical Center
RECRUITING
United States Durham Durham VAMC
RECRUITING
United States Fort Sam Houston Brooke Army Medical Center
RECRUITING
United States Houston Baylor College of Medicine
RECRUITING
United States Houston Harris Health Smith Clinic
RECRUITING
United States Salt Lake City Utah Cancer Specialists
RECRUITING
United States Fort Belvoir Alexander T. Augusta Military Medical Center
RECRUITING
Australia Blacktown Blacktown Hospital
RECRUITING
Australia Fitzroy St Vincents Hospital Melbourne
RECRUITING
Australia Melbourne Box Hill Hospital
RECRUITING
Australia Murdoch Fiona Stanley Hospital
RECRUITING
Australia Nedlands Sir Charles Gairdner Hospital
RECRUITING
Austria Salzburg LKH - Universitätsklinikum der PMU Salzburg
RECRUITING
Austria Vienna Medical University Vienna MUV
RECRUITING
Belgium Brasschaat Algemeen Ziekenhuis Klina
RECRUITING
Belgium Haine-St-Paul Jolimont
RECRUITING
Belgium Kortrijk Az Groeninge
RECRUITING
Belgium Leuven Universitair Ziekenhuis Gasthuisberg
RECRUITING
Belgium Liege CHR de la Citadelle
RECRUITING
Brazil Joinville Instituto Joinvilense de Hematologia e Oncologia Ltda Centro de Hematologia e Oncologia
RECRUITING
Brazil Natal Liga Norte Riograndense Contra O Cancer
RECRUITING
Brazil Niteroi Complexo Hospitalar de Niteroi
RECRUITING
Brazil Rio de Janeiro Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)
RECRUITING
Brazil Salvador Hospital Sao Rafael
RECRUITING
Brazil Sao Paulo Instituto D Or de Pesquisa e Ensino IDOR
RECRUITING
Brazil Sao Paulo Fundacao Antonio Prudente A C Camargo Cancer Center
RECRUITING
Brazil São Paulo Real e Benemérita Associação Portuguesa de Beneficência
RECRUITING
Brazil São Paulo Hospital Alemao Oswaldo Cruz
RECRUITING
Canada Oshawa Lakeridge Health Oshawa
RECRUITING
Canada Montreal CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont
RECRUITING
China Beijing Beijing Chaoyang Hospital
RECRUITING
China Beijing BeiJing JiShuiTan Hospital
RECRUITING
China Changchun The First Bethune Hospital of Jilin University
RECRUITING
China Chengdu Sichuan Provincial Peoples Hospital
RECRUITING
China Guangzhou Sun Yat -Sen University Cancer Center
RECRUITING
China Hangzhou First affiliated Hospital of Zhejiang University
RECRUITING
China Nanchang The First Affiliated Hospital of NanChang University
RECRUITING
China Nanjing Nanjing Drum Tower Hospital
RECRUITING
China Nanning First Affiliated Hospital of Guangxi Medical University
RECRUITING
China Shanghai Shanghai Fourth People s Hospital
RECRUITING
China Shenyang Shengjing Hospital Of China Medical University
RECRUITING
China Shenzhen Shenzhen 2nd People's Hospital
RECRUITING
China Tian Jin Institute of Hematology and Blood Diseases Hospital
RECRUITING
China Tianjin Tianjin Medical University Cancer Institute and Hospital
RECRUITING
China Wenzhou The First Affiliated Hospital of Wenzhou Medical University
RECRUITING
China Wuhan Wuhan Union Hospital
RECRUITING
China Xi'an The Second Affiliated Hospital of Xi'an Jiaotong University
RECRUITING
Czechia Brno Fakultni nemocnice Brno
RECRUITING
Czechia Olomouc Fakultni nemocnice Olomouc
RECRUITING
Czechia Ostrava - Poruba Fakultni Nemocnice Ostrava
RECRUITING
Czechia Praha 2 Vseobecna fakultni nemocnice v Praze
RECRUITING
Denmark Aalborg Aalborg University Hospital
RECRUITING
Denmark Aarhus Aarhus University Hospital
RECRUITING
Denmark Copenhagen Rigshospitalet
RECRUITING
Denmark Herning Regionshospitalet Godstrup
RECRUITING
Denmark Odense C Odense Universitetshospital
RECRUITING
Denmark Vejle Vejle Sygehus
RECRUITING
France AMIENS cedex 1 CHU Amiens - Hopital Sud
RECRUITING
France Caen cedex 9 Hôpital Côte de Nacre
RECRUITING
France Grenoble CHU Grenoble
RECRUITING
France Le Mans Centre Hospitalier du Mans
RECRUITING
France Lille Hopital Saint Vincent de Paul
RECRUITING
France Montpellier CHU de Montpellier Hopital Saint Eloi
RECRUITING
France Nantes Cedex 1 CHU Nantes
RECRUITING
France Paris Hopital Saint-Antoine
RECRUITING
France Paris Hopital de la Pitie Salpetriere
RECRUITING
France Toulouse Institut Universitaire du Cancer Toulouse Oncopole
RECRUITING
France Vandœuvre-lès-Nancy CHU de Nancy - Hopital de Brabois
RECRUITING
Germany Cottbus Medizinische Universitat Lausitz Carl Thiem
RECRUITING
Germany Dresden Universitatsklinikum Carl Gustav Carus Dresden
RECRUITING
Germany Greifswald Universitätsmedizin Greifswald
RECRUITING
Germany Hamburg Asklepios Klinik Altona
RECRUITING
Germany Heidelberg Universitaetsklinikum Heidelberg
RECRUITING
Germany Tübingen Universitatsklinikum Tubingen
RECRUITING
Germany Ulm Universitatsklinikum Ulm
RECRUITING
Germany Zwickau Heinrich-Braun-Klinikum gGmbH
RECRUITING
Greece Athens Attica Alexandra General Hospital of Athens
RECRUITING
Greece Patra Agios Andreas General Hospital of Patra
RECRUITING
Greece Thessaloniki G Papanikolaou Hospital of Thessaloniki
RECRUITING
India Gurgaon Fortis Memorial Research Institute
RECRUITING
India Pune Deenanath Mangeshkar Hospital and Research Centre
RECRUITING
Israel Hadera Hillel Yaffe Medical Center
RECRUITING
Israel Haifa Bnai Zion Medical Center
RECRUITING
Israel Haifa Carmel Medical Center
RECRUITING
Israel Petah Tikva Rabin Medical Center
RECRUITING
Israel Ramat Gan Sheba Medical Center
RECRUITING
Italy Bologna A O U Sant Orsola Malpighi
RECRUITING
Italy Milano Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING
Italy Palermo Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
RECRUITING
Italy Pisa Ospedale Santa Chiara AO Universitaria Pisana
RECRUITING
Italy Reggio Emilia Arcispedale Santa Maria Nuova - IRCCS
RECRUITING
Italy Roma Campus Bio Medico di Roma
RECRUITING
Italy Siena A O Universitaria Senese Ospedale Santa Maria alle Scotte
RECRUITING
Italy Turin A.O.U. Citta della Salute e della Scienza di Torino - Presidio Molinette
RECRUITING
Italy Udine ASUI Santa Maria della Misericordia di Udine
RECRUITING
Italy Varese Ospedale di Circolo e Fondazione Macchi
RECRUITING
Japan Chiba Chiba Cancer Center
RECRUITING
Japan Gifu Ogaki Municipal Hospital
RECRUITING
Japan Gunma National Hospital Organization Shibukawa Medical Center
RECRUITING
Japan Hirakata Kansai Medical University Hospital
RECRUITING
Japan Hitachi Hitachi General Hospital
RECRUITING
Japan Iruma-gun Saitama Medical University Hospital
RECRUITING
Japan Kamogawa City Kameda Medical Center
RECRUITING
Japan Kashiwa National Cancer Center Hospital East
RECRUITING
Japan Kurashiki Kurashiki Central Hospital
RECRUITING
Japan Matsuyama Matsuyama Red Cross Hospital
RECRUITING
Japan Nagakute Aichi Medical University Hospital
RECRUITING
Japan Nagasaki-Shi JRC Nagasaki Genbaku Hospital
RECRUITING
Japan Niigata Niigata University Medical And Dental Hospital
RECRUITING
Japan Okayama National Hospital Organization Okayama Medical Center
RECRUITING
Japan Osaka Osaka Metropolitan University Hospital
RECRUITING
Japan Sapporo Hokkaido University Hospital
COMPLETED
Japan Tokyo Juntendo University Hospital
RECRUITING
Japan Tokyo The Cancer Institute Hospital of JFCR
RECRUITING
Japan Yamanashi Yamanashi Prefectural Central Hospital
RECRUITING
Malaysia Georgetown Hospital Pulau Pinang
RECRUITING
Malaysia Kota Kinabalu Hospital Queen Elizabeth
RECRUITING
Malaysia Kuala Lumpur University Malaya Medical Centre
RECRUITING
Malaysia Subang Jaya Subang Jaya Medical Centre
RECRUITING
Netherlands Amersfoort Meander Medisch Centrum
RECRUITING
Netherlands Amsterdam VUMC Amsterdam
RECRUITING
Netherlands Groningen Universitair Medisch Centrum Groningen
RECRUITING
Netherlands Utrecht UMC Utrecht
RECRUITING
Poland Lublin Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie
RECRUITING
Portugal Lisbon Champalimaud Foundation Champalimaud Centre
RECRUITING
Portugal Porto Instituto Portugues de Oncologia
RECRUITING
Spain Badalona Hosp. Univ. Germans Trias I Pujol
RECRUITING
Spain Jerez de la Frontera Hosp. de Jerez de La Frontera
RECRUITING
Spain Leon Hosp. de Leon
RECRUITING
Spain Madrid Hosp. Univ. Infanta Leonor
RECRUITING
Spain Madrid Hosp. Univ. Ramon Y Cajal
RECRUITING
Spain Madrid Hosp. Univ. 12 de Octubre
RECRUITING
Spain Murcia Hosp. Gral. Univ. J.M. Morales Meseguer
RECRUITING
Spain Oviedo Hospital Universitario Central de Asturias
RECRUITING
Spain Palma de Mallorca Hosp. Son Llatzer
RECRUITING
Spain Pontevedra Hosp. Montecelo
RECRUITING
Spain Pozuelo de Alarcon Hosp. Quiron Madrid Pozuelo
RECRUITING
Spain València Hospital Universitari i Politecnic La Fe
RECRUITING
Sweden Falun Falu Lasarett Medicinkliniken Falun
RECRUITING
Sweden Helsingborg Helsingborgs lasarett
RECRUITING
Sweden Uppsala Akademiska Sjukhuset
RECRUITING
Türkiye Ankara Ankara Gulhane Training and Research Hospital
RECRUITING
Türkiye Ankara Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital
RECRUITING
Türkiye Ankara Ankara University Medical Faculty
RECRUITING
Türkiye Ankara Liv Hospital Ankara
RECRUITING
Türkiye Antalya Antalya Training And Research Hospital
RECRUITING
Türkiye Atakum Ondokuz Mayis University
RECRUITING
Türkiye Denizli Pamukkale University Medical Faculty
RECRUITING
Türkiye Istanbul Medipol University Hospital
RECRUITING
United Kingdom Aberdeen Aberdeen Royal Infirmary
RECRUITING
United Kingdom Birmingham University Hospitals Birmingham NHS Foundation Trust
RECRUITING
United Kingdom Colchester Colchester Hospital University NHS
RECRUITING
United Kingdom Liverpool The Clatterbridge Cancer Centre
RECRUITING
United Kingdom London Chelsea And Westminster Hospital
RECRUITING
United Kingdom London St George's Hospital
RECRUITING
United Kingdom Middlesborough James Cook University Hospital
RECRUITING
United Kingdom Norwich Norfolk and Norwich University Hospital
RECRUITING
United Kingdom Staffordshire Royal Stoke University Hospital
RECRUITING
United States Des Moines Mission Cancer Blood
RECRUITING
United States Bethesda Walter Reed National Military Medical Center
RECRUITING
Brazil Curitiba Liga Paranaense de Combate ao Cancer
RECRUITING
China Wuxi Wuxi People s Hospital
COMPLETED
Poland Katowice Pratia Onkologia Katowice
RECRUITING
United States Aurora Rocky Mountain Cancer Centers
RECRUITING
United States Metairie East Jefferson General Hospital Bone Marrow Transport Clinic
COMPLETED
United States Silver Spring Maryland Oncology Hematology P A
RECRUITING
United States Chesterfield Saint Lukes Hospital Saint Lukes Cancer Specialists
COMPLETED
United States Lancaster Penn Medicine Lancaster General Health
COMPLETED
United States Houston Michael E DeBakey VA Medical Center
RECRUITING
United States Norfolk Virginia Oncology Associates
RECRUITING
United States Tacoma NorthWest Medical Specialties, PLLC
RECRUITING
Brazil Brasilia Hospitais Integradaos da Gavea S/A - DF Star
COMPLETED
Brazil Caxias do Sul Fundacao Universidade de Caxias do Sul
COMPLETED
Brazil Sao Jose do Rio Preto Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
RECRUITING
Brazil Sao Paulo Sociedade Beneficente de Senhoras Hospital Sirio Libanes
COMPLETED
Brazil Sao Paulo Clinica Medica Sao Germano LTDA
RECRUITING
Brazil São Paulo Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
COMPLETED
Canada Calgary Arthur J E Child Comprehensive Cancer Centre
RECRUITING
Canada Saint John Saint John Regional Hospital
COMPLETED
Canada Brampton Brampton Civic Hospital
COMPLETED
China Changsha The Third Xiangya Hospital, Central South University
COMPLETED
China Chongqing Chongqing University Cancer Hospital
COMPLETED
China Fu Zhou Fujian Meidical University Union Hospital
COMPLETED
China Harbin Harbin medical university cancer hospital
COMPLETED
China Zhengzhou Henan Cancer Hospital
COMPLETED
France Paris Hopital Necker Enfants Malades
RECRUITING
Germany Marburg Universitaetsklinikum Giessen und Marburg GmbH
COMPLETED
India Jaipur Bhagwan Mahaveer Cancer Hospital & Research Centre
RECRUITING
Israel Tel-Aviv Tel Aviv Sourasky Medical Center
RECRUITING
Japan Bunkyo ku Institute of Science Tokyo Hospital
RECRUITING
Japan Yamagata Yamagata University Hospital
RECRUITING
Poland Gdansk Uniwersyteckie Centrum Kliniczne
RECRUITING
Poland Kielce Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach
RECRUITING
Portugal Almada Uls Almada Seixal - Hosp. Garcia de Orta
RECRUITING
Portugal Braga Uls Braga - Hosp. Braga
RECRUITING
Portugal Vila Nova de Gaia Uls Gaia Espinho
RECRUITING
Spain Hospitalet de Llobregat Institut Catala d Oncologia L Hospitalet
RECRUITING
Show More
Geo Locations

61.21806, -149.90028

37.87159, -122.27275

33.76696, -118.18923

33.78779, -117.85311

33.97918, -118.03284

41.71982, -72.83204

25.77427, -80.19366

28.53834, -81.37924

26.10037, -80.39977

42.35843, -71.05977

39.92595, -75.11962

40.71427, -74.00597

35.99403, -78.89862

29.45746, -98.4472

29.76328, -95.36327

29.76328, -95.36327

40.76078, -111.89105

38.7119, -77.14589

-33.76667, 150.91667

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47.79941, 13.04399

48.20849, 16.37208

51.2912, 4.49182

50.46185, 4.1767

50.82803, 3.26487

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43.90012, -78.84957

45.50884, -73.58781

39.9075, 116.39723

39.9075, 116.39723

43.88, 125.32278

30.66667, 104.06667

23.11667, 113.25

30.29365, 120.16142

28.68396, 115.85306

32.06167, 118.77778

22.81667, 108.31667

31.22222, 121.45806

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22.54554, 114.0683

39.1251999, 117.191

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27.99942, 120.66682

30.58333, 114.26667

34.25833, 108.92861

49.19522, 16.60796

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49.83465, 18.28204

50.08804, 14.42076

57.048, 9.9187

56.15674, 10.21076

55.67594, 12.56553

56.13932, 8.97378

55.39594, 10.38831

55.70927, 9.5357

49.9, 2.3

49.18585, -0.35912

45.16667, 5.71667

48, 0.2

50.63297, 3.05858

43.61092, 3.87723

47.21725, -1.55336

48.85341, 2.3488

48.85341, 2.3488

43.60426, 1.44367

48.65, 6.18333

51.75769, 14.32888

51.05089, 13.73832

54.09311, 13.38786

53.57532, 10.01534

49.40768, 8.69079

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50.72724, 12.48839

37.9804964, 23.7561153

38.24444, 21.73444

40.64361, 22.93086

28.4601, 77.02635

18.51957, 73.85535

32.44192, 34.9039

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32.08227, 34.81065

44.49381, 11.33875

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38.13205, 13.33561

43.70853, 10.4036

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45.07049, 7.68682

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45.82058, 8.82511

35.6, 140.11667

35.42291, 136.76039

36.52592, 138.97142

34.81352, 135.64914

36.6, 140.65

35.9395823, 139.3050206

35.0969, 140.1003

35.86224, 139.97732

34.58333, 133.76667

33.83916, 132.76574

35.17325, 137.05667

32.75, 129.88333

37.88637, 139.00589

34.65, 133.93333

34.69374, 135.50218

43.06667, 141.35

35.6895, 139.69171

35.6895, 139.69171

35.6709649, 138.5507574

5.4197312, 100.3170452

5.9749, 116.0724

3.1412, 101.68653

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52.155, 5.3875

52.37403, 4.88969

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51.25, 22.56667

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36.68645, -6.13606

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60.60357, 15.62597

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39.91987, 32.85427

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36.90812, 30.69556

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38.23333, 140.36667

54.35205, 18.64637

50.87033, 20.62752

38.67902, -9.1569

41.55032, -8.42005

41.13363, -8.61742

41.35967, 2.10028

x
50

Indicates 50+ sites in this region: click to zoom in.

10

Indicates 10+ sites in this region: click to zoom in.

5

Indicates < 10 sites in this region: click to zoom in.

Corresponds to individual site.

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