Inclusion Criteria:

* Must have a histologically or cytologically-confirmed diagnosis of adenocarcinoma of the prostate

* Must have documented metastatic hormone-sensitive prostate cancer (mHSPC)

* Must have agreed with the treating physician the initiation of either apalutamide or enzalutamide (plus androgen deprivation therapy [ADT]) treatment, per the treating physician's decision, prior to enrollment into the study

* Must sign, and/or their legally acceptable representative where applicable must sign, a participation agreement/ informed consent form (ICF) allowing data collection and source data verification in accordance with local requirements

* Must have baseline prostate-specific antigen (PSA) captured before the first administration of apalutamide or enzalutamide

* Must agree to complete patient-reported outcomes (PROs) during the study, including the baseline ones collected before the first administration of apalutamide or enzalutamide

Exclusion Criteria:

* Has already received or is currently receiving either apalutamide or enzalutamide, or any other novel hormonal treatments (including but not limited to abiraterone acetate and darolutamide)

* Is currently receiving an active treatment for prostate cancer as part of an interventional study

* Has a progression under ADT treatment (and thus became castrate-resistant) prior to start of apalutamide or enzalutamide treatment

* Has received ADT treatment for more than 2 months prior to apalutamide or enzalutamide treatment initiation

* Has received prior immediate docetaxel for the treatment of mHSPC

* Participants is not treated in line with current Summary of Product Characteristics for apalutamide or enzalutamide