A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and

A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment (MonumenTAL-3)

Last Updated March 5, 2025

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CR109082

OVERVIEW

Sexes Eligible for Study
all
Age
18+ years
Phase
phase 3

3
Sites
216 Sites
Status

Recruiting

SUMMARY

Overall rationale of the study is that combination treatments of talquetamab, daratumumab, pomalidomide and dexamethasone may lead to enhanced clinical responses in treatment of relapsed or refractory multiple myeloma through multiple mechanisms of action. The study is divided into 3 phases: screening, treatment (until confirmed progressive disease, death, intolerable toxicity, withdrawal of consent, or end of the study, whichever occurs first), and posttreatment follow-up (until death, withdrawal of consent, loss to follow-up, or end of the study, whichever occurs first). Efficacy, safety (physical examinations, neurologic examinations, Eastern Cooperative Oncology Group [ECOG] performance status, clinical laboratory tests, vital signs, and AE monitoring), pharmacokinetics (PK), immunogenicity, and biomarkers will be assessed at specified time points. Total duration of study will be up to 6 years 6 months.

CONDITIONS

Relapsed or Refractory Multiple Myeloma

ELIGIBILITY

Inclusion Criteria:

* Documented multiple myeloma as defined: a) Multiple myeloma diagnosis according to the International Myeloma Working Group (IMWG) diagnostic criteria and b) Measurable disease at screening as defined by any of the following: i) Serum M-protein level greater than or equal to (>=) 0.5 grams per deciliter (g/dL) (central laboratory); ii) Urine M-protein level >= 200 milligram (mg) per 24 hours (central laboratory); iii) Light chain multiple myeloma without measurable M-protein in the serum or the urine: serum immunoglobulin free light chain >= 10 milligram per deciliter (mg/dL) (central laboratory), and abnormal serum immunoglobulin kappa lambda free light chain ratio
* Relapsed or refractory disease as defined by: i) Relapsed disease is defined as an initial response to prior treatment, followed by confirmed progressive disease by IMWG criteria greater than (>) 60 days after cessation of treatment; ii) Refractory disease is defined as less than (<) 25 percent (%) reduction in monoclonal paraprotein (M-protein) or confirmed progressive disease by IMWG criteria during previous treatment or less than or equal to (<=) 60 days after cessation of treatment
* Received at least 1 prior line of antimyeloma therapy including a proteasome inhibitor (PI) and lenalidomide. Participants who have received only 1 prior line of antimyeloma therapy must be considered lenalidomide-refractory (that is, have demonstrated progressive disease by IMWG criteria on or within 60 days of completion of lenalidomide-containing regimen). Participants who have received >=2 prior lines of antimyeloma therapy must be considered lenalidomide exposed
* Documented evidence of progressive disease based on investigator's determination of response by the IMWG criteria on or after their last regimen
* Have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or 2 at screening and immediately prior to the start of administration of study treatment

Exclusion Criteria:

* Contraindications or life-threatening allergies, hypersensitivity, or intolerance to study drug excipients
* Disease is considered refractory to an anti-cluster of differentiation 38 (CD38) monoclonal antibody as defined per IMWG consensus guidelines (progression during treatment or within 60 days of completing therapy with an anti-CD38 monoclonal antibody)
* Received prior pomalidomide therapy
* A maximum cumulative dose of corticosteroids to >=140 milligrams (mg) of prednisone or equivalent within 14-day period before the first dose of study drug
* Known active central nervous system (CNS) involvement or exhibits clinical signs of meningeal involvement of multiple myeloma. If either is suspected, negative whole brain magnetic resonance imaging (MRI) and lumbar cytology are required
* Plasma cell leukemia (per IMWG criteria) at the time of screening, Waldenström's macroglobulinemia, polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS syndrome), or primary amyloid light chain amyloidosis

Inclusion Criteria:

More...

DETAILS

LOCATIONS

Locations in:

United States, Belgium, Brazil, China, Czechia, France, Germany, Greece, Israel, Italy, Japan, South Korea, Netherlands, Poland, Spain, Taiwan, United Kingdom, Türkiye

Country (18)	City or Province (216)	Status
United States	Tucson The University of Arizona Cancer Center	RECRUITING
United States	Little Rock University of Arkansas for Medical Sciences	RECRUITING
United States	Washington MedStar Georgetown University Hospital	RECRUITING
United States	Hollywood Memorial Healthcare System	RECRUITING
United States	Miami University of Miami Health System	RECRUITING
United States	Chicago University Of Illinois	RECRUITING
United States	New Orleans Tulane University Hospital & Clinics	COMPLETED
United States	New Orleans Ochsner Health System	RECRUITING
United States	Baltimore Johns Hopkins University	RECRUITING
United States	Boston Massachusetts General	RECRUITING
United States	Boston Boston University Medical Center	RECRUITING
United States	Worcester University of Massachusetts Medical School	RECRUITING
United States	Ann Arbor University of Michigan Health System	RECRUITING
United States	Minneapolis University Of Minnesota	RECRUITING
United States	Jackson University of Mississippi Medical Center	RECRUITING
United States	Saint Louis Washington University School Of Medicine	RECRUITING
United States	New Brunswick Rutgers Cancer Institute of New Jersey	RECRUITING
United States	New York NYU Langone Health	COMPLETED
United States	Syracuse SUNY Upstate Medical University	RECRUITING
United States	Chapel Hill University of North Carolina	RECRUITING
United States	Charlotte Levine Cancer Institute, Carolinas HealthCare System	RECRUITING
United States	Winston-Salem Novant Health	RECRUITING
United States	Winston-Salem Wake Forest Baptist Medical Center	RECRUITING
United States	Cleveland University Hospitals Cleveland Medical Center	RECRUITING
United States	Columbus The Ohio State University Wexner Medical Center - James Cancer Hospital	RECRUITING
United States	Columbus OhioHealth	RECRUITING
United States	Charleston Medical University of South Carolina	RECRUITING
United States	Memphis Baptist Cancer Center	RECRUITING
United States	Houston Houston Methodist Hospital	RECRUITING
United States	Houston MD Anderson Cancer Center	RECRUITING
United States	Lubbock Joe Arrington Cancer Research Treatment Center	RECRUITING
United States	Salt Lake City Huntsman Cancer Institute	RECRUITING
United States	Charlottesville University of Virginia	RECRUITING
United States	Richmond Virginia Commonwealth University - Massey Cancer Center	RECRUITING
United States	Seattle Fred Hutchinson Cancer Research Center	RECRUITING
Belgium	Brussel UZ Brussel	ACTIVE_NOT_RECRUITING
Belgium	Edegem UZA	ACTIVE_NOT_RECRUITING
Belgium	Hasselt Virga Jessa Ziekenhuis	COMPLETED
Belgium	Liège CHC MontLegia	ACTIVE_NOT_RECRUITING
Belgium	Ottignies Clinique Saint Pierre	ACTIVE_NOT_RECRUITING
Brazil	Belo Horizonte Santa Casa de Misericordia de Belo Horizonte	RECRUITING
Brazil	Brasilia Hospitais Integradaos da Gavea S/A - DF Star	RECRUITING
Brazil	Caxias do Sul Fundacao Universidade de Caxias do Sul	RECRUITING
Brazil	Porto Alegre Irmandade Santa Casa de Misericordia de Porto Alegre	RECRUITING
Brazil	Salvador Hospital Sao Rafael	RECRUITING
Brazil	Sao Paulo Instituto D Or de Pesquisa e Ensino IDOR	RECRUITING
Brazil	Sao Paulo Fundacao Antonio Prudente A C Camargo Cancer Center	RECRUITING
Brazil	São Paulo Real e Benemerita Associacao Portuguesa de Beneficencia	RECRUITING
China	Beijing Peking Union Medical College Hospital	RECRUITING
China	Beijing Beijing Chaoyang Hospital	RECRUITING
China	Beijing Peking University First Hospital	RECRUITING
China	Changchun The First Hospital of Jilin University	RECRUITING
China	ChangSha The second Xiangya Hospital of Central South University	RECRUITING
China	Chengdu Sichuan Academy of Medical Science Sichuan Provincial People's Hospital	RECRUITING
China	Fuzhou Fujian Medical University Union Hospital	RECRUITING
China	Guangzhou Guangdong Provincial People's Hospital	RECRUITING
China	Hangzhou The First Affiliated Hospital Zhejiang University College of Medicine	RECRUITING
China	Nanjing Nanjing Drum Tower Hospital	RECRUITING
China	Shanghai Tongji Hospital of Tongji University	RECRUITING
China	Shanghai Shanghai Fourth People s Hospital	RECRUITING
China	Shenzhen Peking University Shenzhen Hospital	RECRUITING
China	Su Zhou First Affiliated Hospital SooChow University	RECRUITING
China	Tianjin Tianjin cancer hospital	RECRUITING
China	Tianjin Institute of Hematology & Blood Disease Hospital Chinese Academy of Medical Science	RECRUITING
China	Wuhan Tongji Hospital, Tongji Medical College of HUST	COMPLETED
China	Zhengzhou Henan Cancer Hospital	RECRUITING
Czechia	Brno Fakultni nemocnice Brno	COMPLETED
Czechia	Hradec Kralove Fakultni nemocnice Hradec Kralove	ACTIVE_NOT_RECRUITING
Czechia	Olomouc Fakultni nemocnice Olomouc	COMPLETED
Czechia	Ostrava - Poruba Fakultni Nemocnice Ostrava	ACTIVE_NOT_RECRUITING
Czechia	Praha 10 Fakultni nemocnice Kralovske Vinohrady	ACTIVE_NOT_RECRUITING
Czechia	Praha 2 Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie	ACTIVE_NOT_RECRUITING
France	Creteil APHP - Hopital Henri Mondor	ACTIVE_NOT_RECRUITING
France	Dijon CHU Dijon	COMPLETED
France	Lyon Centre Leon Berard	COMPLETED
France	Montpellier Cedex 5 CHU de Montpellier - Hopital Saint-Eloi	ACTIVE_NOT_RECRUITING
France	Nantes CHU de Nantes hotel Dieu	ACTIVE_NOT_RECRUITING
France	Paris Cedex 12 CHU Hopital Saint Antoine	ACTIVE_NOT_RECRUITING
France	Pessac CHRU - Hôpital du Haut Lévêque - Centre François Magendie	ACTIVE_NOT_RECRUITING
France	TOULOUSE Cedex 9 Institut Universitaire du cancer de Toulouse-Oncopole	ACTIVE_NOT_RECRUITING
Germany	Hamburg Asklepios Klinik Altona	RECRUITING
Germany	Heidelberg Universitaetsklinikum Heidelberg	RECRUITING
Germany	Koeln Universitaetsklinikum Koelnt	RECRUITING
Germany	Leipzig Universitaetsklinikum Leipzig	RECRUITING
Germany	Mainz Universitätsmedizin der Johannes Gutenberg Universität	COMPLETED
Greece	Thessaloniki Anticancer Hospital of Thessaloniki Theageneio	COMPLETED
Israel	Afula Ha'Emek Medical Center	ACTIVE_NOT_RECRUITING
Israel	Hadera Hillel Yaffe Medical Center	COMPLETED
Israel	Haifa Bnai Zion Medical Center	ACTIVE_NOT_RECRUITING
Israel	Haifa Rambam Medical Center	ACTIVE_NOT_RECRUITING
Israel	Haifa Carmel Medical Center	ACTIVE_NOT_RECRUITING
Israel	Jerusalem Shaare Zedek Medical Center	ACTIVE_NOT_RECRUITING
Israel	Nahariya Galilee Medical Center	COMPLETED
Israel	Petah Tikva Beilinson medical center	ACTIVE_NOT_RECRUITING
Israel	Ramat Gan Sheba Medical Center	ACTIVE_NOT_RECRUITING
Israel	Safed Ziv Medical Center	COMPLETED
Israel	Tel Aviv Sourasky (Ichilov) Medical Center	ACTIVE_NOT_RECRUITING
Italy	Ancona A.O. Universitaria Ospedali Riuniti di Ancona	ACTIVE_NOT_RECRUITING
Italy	Bari Policlinico di Bari	ACTIVE_NOT_RECRUITING
Italy	Bologna Azienda Ospedaliera Policlinico S. Orsola-Malpighi	ACTIVE_NOT_RECRUITING
Italy	Brescia Azienda Ospedaliera Spedali Civili di Brescia	ACTIVE_NOT_RECRUITING
Italy	Catania PO G.Rodolico, AOU Policlinico-Vittorio Emanuele Catania	ACTIVE_NOT_RECRUITING
Italy	Milano Fondazione IRCCS Istituto Nazionale dei Tumori	ACTIVE_NOT_RECRUITING
Italy	Milano ASST Grande Ospedale Metropolitano Niguarda	ACTIVE_NOT_RECRUITING
Italy	Padova Azienda Ospedaliera Universitaria di Padova	ACTIVE_NOT_RECRUITING
Italy	Palermo Ospedale Villa Sofia-Cervello	ACTIVE_NOT_RECRUITING
Italy	Pavia Fondazione IRCCS Policlinico San Matteo	ACTIVE_NOT_RECRUITING
Italy	Reggio Emilia Arcispedale Santa Maria Nuova - IRCCS	ACTIVE_NOT_RECRUITING
Italy	San Giovanni Rotondo IRCCS Ospedale Casa Sollievo della Sofferenza	ACTIVE_NOT_RECRUITING
Italy	Torino A.O.U. Città della Salute e della Scienza	ACTIVE_NOT_RECRUITING
Japan	Koshigaya Dokkyo Medical University Saitama Medical Center	COMPLETED
South Korea	Busan Dong-A University Hospital	ACTIVE_NOT_RECRUITING
South Korea	Gyeonggi-do National Cancer Center	ACTIVE_NOT_RECRUITING
South Korea	Incheon Gachon University Gil Medical Center	ACTIVE_NOT_RECRUITING
South Korea	Jeollanam-do Chonnam National University Hwasun Hospital	ACTIVE_NOT_RECRUITING
South Korea	Jeonju-si Jeonbuk National University Hospital	ACTIVE_NOT_RECRUITING
South Korea	Seoul Seoul National University Hospital	ACTIVE_NOT_RECRUITING
South Korea	Seoul Severance Hospital Yonsei University Health System	ACTIVE_NOT_RECRUITING
South Korea	Seoul Asan Medical Center	ACTIVE_NOT_RECRUITING
South Korea	Seoul Samsung Medical Center	ACTIVE_NOT_RECRUITING
South Korea	Seoul The Catholic University of Korea Seoul St Marys Hospital	ACTIVE_NOT_RECRUITING
Netherlands	Dordrecht Albert Schweitzer ziekenhuis-lokatie Dordwijk	ACTIVE_NOT_RECRUITING
Netherlands	Eindhoven Maxima Medisch Centrum	ACTIVE_NOT_RECRUITING
Netherlands	Rotterdam Erasmus MC	ACTIVE_NOT_RECRUITING
Poland	Brzozow Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza	ACTIVE_NOT_RECRUITING
Poland	Krakow Szpital Uniwersytecki w Krakowie	COMPLETED
Poland	Olsztyn Szpital Kliniczny MSWiA z Warminsko Mazurskim Centrum Onkologii w Olsztynie Oddzial Hematologii	COMPLETED
Poland	Szczecin Uniwersytecki Szpital Kliniczny Nr 1 PUM im prof Tadeusza Sokolowskiego w Szczecinie	ACTIVE_NOT_RECRUITING
Poland	Warszawa Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy	ACTIVE_NOT_RECRUITING
Spain	Badalona Hosp. Univ. Germans Trias I Pujol	RECRUITING
Spain	Barcelona Hosp. de La Santa Creu I Sant Pau	RECRUITING
Spain	Barcelona Hosp Univ Vall D Hebron	RECRUITING
Spain	Barcelona Hosp Clinic de Barcelona	RECRUITING
Spain	Jerez de la Frontera Hosp. de Jerez de La Frontera	RECRUITING
Spain	Leon Hosp. de Leon	RECRUITING
Spain	Madrid Hosp. Univ. de La Princesa	COMPLETED
Spain	Madrid Hosp. Univ. Ramon Y Cajal	COMPLETED
Spain	Madrid Hosp. Univ. 12 de Octubre	RECRUITING
Spain	Malaga Hosp Virgen de La Victoria	RECRUITING
Spain	Pamplona Clinica Univ. de Navarra	RECRUITING
Spain	Salamanca Hosp Clinico Univ de Salamanca	RECRUITING
Spain	San Cristóbal de La Laguna Hosp. Univ. de Canarias	RECRUITING
Spain	Valencia Hosp. Univ. Dr. Peset	RECRUITING
Taiwan	Kaohsiung Kaohsiung Medical University Chung Ho Memorial Hospital	ACTIVE_NOT_RECRUITING
Taiwan	Kaohsiung Kaohsiung Chang Gung Memorial Hospital	ACTIVE_NOT_RECRUITING
Taiwan	Taichung City China Medical University Hospital	ACTIVE_NOT_RECRUITING
Taiwan	Tainan National Cheng Kung University Hospital	ACTIVE_NOT_RECRUITING
Taiwan	Taipei National Taiwan University Hospital	ACTIVE_NOT_RECRUITING
United Kingdom	Blackpool Blackpool Victoria Hospital	RECRUITING
United Kingdom	Dundee Ninewells Hospital & Medical School	RECRUITING
United Kingdom	London Hammersmith Hospital	RECRUITING
United Kingdom	Newcastle Upon Tyne Newcastle Freeman Hospital	RECRUITING
United Kingdom	Nottingham Nottingham City Hospital	RECRUITING
United Kingdom	Plymouth University Hospitals Plymouth NHS Trust	RECRUITING
United Kingdom	Sutton Royal Marsden Hospital	RECRUITING
United Kingdom	Wolverhampton New Cross Hospital	RECRUITING
United States	Norwalk Norwalk Hospital-oncology	COMPLETED
Belgium	Yvoir UCL Mont Godinne	COMPLETED
Brazil	Curitiba Liga Paranaense de Combate ao Cancer	RECRUITING
Brazil	Rio de Janeiro Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)	RECRUITING
France	Nice N/a CHU HOPITAL DE L'ARCHET - Hematology	TERMINATED
Poland	Katowice Pratia Onkologia Katowice	ACTIVE_NOT_RECRUITING
Poland	Wroclaw Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu	ACTIVE_NOT_RECRUITING
United States	Washington George Washington University	COMPLETED
United States	Westwood University of Kansas	COMPLETED
United States	Charlotte Novant Health	COMPLETED
United States	Philadelphia Thomas Jefferson University	COMPLETED
Brazil	Barretos Fundacao Pio XII	COMPLETED
Brazil	Florianopolis Centro de Pesquisa e Ensino em Oncologia de Santa Catarina CEPEN	RECRUITING
Brazil	Natal Liga Norte Riograndense Contra O Cancer	COMPLETED
Brazil	Ribeirao Preto Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP	RECRUITING
Brazil	Sao Paulo Hospital Paulistano	COMPLETED
Brazil	São Paulo Sociedade Beneficente de Senhoras Hospital Sirio Libanes	RECRUITING
Brazil	São Paulo Clinica Sao Germano	RECRUITING
China	Guang Zhou Shi Sun Yat-Sen University Cancer Center	RECRUITING
Germany	Berlin Charite Campus Benjamin Franklin	COMPLETED
Germany	Wuerzburg Universitaetsklinikum Wuerzburg	COMPLETED
Greece	Athens Attica Alexandra General Hospital of Athens	ACTIVE_NOT_RECRUITING
Greece	Thessalonikis G Papanikolaou Hospital of Thessaloniki	ACTIVE_NOT_RECRUITING
Israel	Be Er Ya Akov Shamir Medical Center Assaf Harofeh	ACTIVE_NOT_RECRUITING
Italy	Roma Presidio Ospedaliero Santo Spirito in Sassia	COMPLETED
Japan	Bunkyo ku Institute of Science Tokyo Hospital	ACTIVE_NOT_RECRUITING
Japan	Chiba Chiba Cancer Center	ACTIVE_NOT_RECRUITING
Japan	Fukuoka Fukuoka University Hospital	ACTIVE_NOT_RECRUITING
Japan	Gifu Ogaki Municipal Hospital	COMPLETED
Japan	Gunma Gunma University Hospital	ACTIVE_NOT_RECRUITING
Japan	Hirakata Kansai Medical University Hospital	ACTIVE_NOT_RECRUITING
Japan	Hyogo Japanese Red Cross Society Himeji Hospital	COMPLETED
Japan	Hyôgo Hyogo Medical University Hospital	ACTIVE_NOT_RECRUITING
Japan	Kamakura-shi Shonan Kamakura General Hospital	ACTIVE_NOT_RECRUITING
Japan	Kashiwa National Cancer Center Hospital East	ACTIVE_NOT_RECRUITING
Japan	Kumamoto Kumamoto University Hospital	ACTIVE_NOT_RECRUITING
Japan	Kyoto Kyoto Kuramaguchi Medical Center	ACTIVE_NOT_RECRUITING
Japan	Matsumoto National Hospital Organization Matsumoto Medical Center	ACTIVE_NOT_RECRUITING
Japan	Niigata Niigata Cancer Center Hospital	ACTIVE_NOT_RECRUITING
Japan	Otake National Hospital Organization Hiroshima-Nishi Medical Center	ACTIVE_NOT_RECRUITING
Japan	Sapporo-shi Hokkaido University Hospital	ACTIVE_NOT_RECRUITING
Japan	Sendai Tohoku University Hospital	ACTIVE_NOT_RECRUITING
Japan	Shiwa-gun Iwate Medical University Hospital	ACTIVE_NOT_RECRUITING
Japan	Suita-shi Osaka University Hospital	ACTIVE_NOT_RECRUITING
Japan	Tokyo The Cancer Institute Hospital of JFCR	ACTIVE_NOT_RECRUITING
Poland	Gdansk Uniwersyteckie Centrum Kliniczne	ACTIVE_NOT_RECRUITING
Poland	Kielce Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach	ACTIVE_NOT_RECRUITING
Poland	Lublin Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli	ACTIVE_NOT_RECRUITING
Poland	Torun Wojewodzki Szpital Zespolony im L Rydygiera w Toruniu	ACTIVE_NOT_RECRUITING
Spain	El Palmar Hosp. Univ. Virgen de La Arrixaca	RECRUITING
Spain	Madrid Hosp Univ Hm Sanchinarro	COMPLETED
Türkiye	Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Hematology Unit	ACTIVE_NOT_RECRUITING
Türkiye	Ankara Ankara University Medical Faculty	ACTIVE_NOT_RECRUITING
Türkiye	Ankara Liv Hospital Ankara	ACTIVE_NOT_RECRUITING
Türkiye	Antalya Antalya Training And Research Hospital	ACTIVE_NOT_RECRUITING
Türkiye	Istabul Medipol Mega University Hospital	ACTIVE_NOT_RECRUITING
Türkiye	Istanbul Istanbul University Istanbul Medical Faculty	COMPLETED
Türkiye	Istanbul Istanbul University Cerrahpasa Medical Faculty	ACTIVE_NOT_RECRUITING
Türkiye	Izmir Dokuz Eylul University Medical Faculty	ACTIVE_NOT_RECRUITING
Türkiye	Samsun Ondokuz Mayis University	ACTIVE_NOT_RECRUITING

Geo Locations

32.22174, -110.92648

34.74648, -92.28959

38.89511, -77.03637

26.0112, -80.14949

25.77427, -80.19366

41.85003, -87.65005

29.95465, -90.07507

39.29038, -76.61219

42.35843, -71.05977

42.26259, -71.80229

42.27756, -83.74088

44.97997, -93.26384

32.29876, -90.18481

38.62727, -90.19789

40.48622, -74.45182

40.71427, -74.00597

43.04812, -76.14742

35.9132, -79.05584

35.22709, -80.84313

36.09986, -80.24422

41.4995, -81.69541

39.96118, -82.99879

32.77657, -79.93092

35.14953, -90.04898

29.76328, -95.36327

33.57786, -101.85517

40.76078, -111.89105

38.02931, -78.47668

37.55376, -77.46026

47.60621, -122.33207

50.85045, 4.34878

51.15662, 4.44504

50.93106, 5.33781

50.63373, 5.56749

50.66535, 4.56679

-19.92083, -43.93778

-15.77972, -47.92972

-29.16806, -51.17944

-30.03306, -51.23

-12.97111, -38.51083

-23.5475, -46.63611

39.9075, 116.39723

43.88, 125.32278

28.19874, 112.97087

30.66667, 104.06667

26.06139, 119.30611

23.11667, 113.25

30.29365, 120.16142

32.06167, 118.77778

31.22222, 121.45806

22.54554, 114.0683

31.2982999, 120.643

39.14222, 117.17667

30.58333, 114.26667

34.75778, 113.64861

49.19522, 16.60796

50.20923, 15.83277

49.59552, 17.25175

49.83465, 18.28204

50.08804, 14.42076

48.78333, 2.46667

47.31667, 5.01667

45.74848, 4.84669

43.61092, 3.87723

47.21725, -1.55336

48.85341, 2.3488

44.81011, -0.64129

43.60426, 1.44367

53.57532, 10.01534

49.40768, 8.69079

50.93333, 6.95

51.33962, 12.37129

49.98419, 8.2791

40.64361, 22.93086

32.60907, 35.2892

32.44192, 34.9039

32.81841, 34.9885

31.76904, 35.21633

33.00892, 35.09814

32.08707, 34.88747

32.08227, 34.81065

32.96465, 35.496

32.08088, 34.78057

43.5942, 13.50337

41.11148, 16.8554

44.49381, 11.33875

45.53558, 10.21472

37.49223, 15.07041

45.46427, 9.18951

45.40797, 11.88586

38.13205, 13.33561

45.19205, 9.15917

44.69825, 10.63125

41.70643, 15.7277

45.07049, 7.68682

35.89035, 139.78916

35.10278, 129.04028

37.58944, 126.76917

37.45646, 126.70515

35.056264, 127.0025403

35.8451841, 127.1422347

37.566, 126.9784

51.81, 4.67361

51.44083, 5.47778

51.9225, 4.47917

49.69501, 22.01926

50.06143, 19.93658

53.77995, 20.49416

53.42894, 14.55302

52.22977, 21.01178

41.45004, 2.24741

41.38879, 2.15899

36.68645, -6.13606

42.60003, -5.57032

40.4165, -3.70256

36.72016, -4.42034

42.81687, -1.64323

40.96882, -5.66388

28.4853, -16.32014

39.46975, -0.37739

22.61626, 120.31333

24.1469, 120.6839

22.99083, 120.21333

25.04776, 121.53185

53.81667, -3.05

56.46913, -2.97489

51.50853, -0.12574

54.97328, -1.61396

52.9536, -1.15047

50.37153, -4.14305

51.35, -0.2

52.58547, -2.12296

41.1176, -73.4079

50.3279, 4.88059

-25.42778, -49.27306

-22.90278, -43.2075

46.227638, 2.213749

50.25841, 19.02754

51.1, 17.03333

38.89511, -77.03637

39.04056, -94.6169

35.22709, -80.84313

39.95233, -75.16379

-20.55722, -48.56778

-27.59667, -48.54917

-5.795, -35.20944

-21.1775, -47.81028

-23.5475, -46.63611

23.10261, 113.4240305

52.52437, 13.41053

49.79391, 9.95121

37.9804964, 23.7561153

40.6455525, 23.0118975

31.943507, 34.83904

41.89193, 12.51133

35.37517, 139.92991

35.6, 140.11667

33.6, 130.41667

35.42291, 136.76039

36.52592, 138.97142

34.81352, 135.64914

34.8579518, 134.5453787

34.718641, 135.3791967

35.30889, 139.55028

35.86224, 139.97732

32.80589, 130.69182

35.02107, 135.75385

36.23333, 137.96667

37.88637, 139.00589

34.20752, 132.22062

43.06667, 141.35

38.26667, 140.86667

33.23058, 133.24871

34.76143, 135.51567

35.6895, 139.69171

54.35205, 18.64637

50.87033, 20.62752

51.25, 22.56667

53.01375, 18.59814

37.93939, -1.16095

40.4165, -3.70256

39.91987, 32.85427

36.90812, 30.69556

41.0502188, 28.8334623

41.01384, 28.94966

38.41273, 27.13838

41.27976, 36.3361

Indicates 50+ sites in this region: click to zoom in.

Indicates 10+ sites in this region: click to zoom in.

Indicates < 10 sites in this region: click to zoom in.

Corresponds to individual site.

OVERVIEW

Sexes Eligible for Study

Age

Phase

Sites

Status

SUMMARY

CONDITIONS

ELIGIBILITY

DETAILS

LOCATIONS

32.22174, -110.92648

34.74648, -92.28959

38.89511, -77.03637

26.0112, -80.14949

25.77427, -80.19366

41.85003, -87.65005

29.95465, -90.07507

29.95465, -90.07507

39.29038, -76.61219

42.35843, -71.05977

42.35843, -71.05977

42.26259, -71.80229

42.27756, -83.74088

44.97997, -93.26384

32.29876, -90.18481

38.62727, -90.19789

40.48622, -74.45182

40.71427, -74.00597

43.04812, -76.14742

35.9132, -79.05584

35.22709, -80.84313

36.09986, -80.24422

36.09986, -80.24422

41.4995, -81.69541

39.96118, -82.99879

39.96118, -82.99879

32.77657, -79.93092

35.14953, -90.04898

29.76328, -95.36327

29.76328, -95.36327

33.57786, -101.85517

40.76078, -111.89105

38.02931, -78.47668

37.55376, -77.46026

47.60621, -122.33207

50.85045, 4.34878

51.15662, 4.44504

50.93106, 5.33781

50.63373, 5.56749

50.66535, 4.56679

-19.92083, -43.93778

-15.77972, -47.92972

-29.16806, -51.17944

-30.03306, -51.23

-12.97111, -38.51083

-23.5475, -46.63611

-23.5475, -46.63611

-23.5475, -46.63611

39.9075, 116.39723

39.9075, 116.39723

39.9075, 116.39723

43.88, 125.32278

28.19874, 112.97087

30.66667, 104.06667

26.06139, 119.30611

23.11667, 113.25

30.29365, 120.16142

32.06167, 118.77778

31.22222, 121.45806

31.22222, 121.45806

22.54554, 114.0683

31.2982999, 120.643

39.14222, 117.17667

39.14222, 117.17667

30.58333, 114.26667

34.75778, 113.64861

49.19522, 16.60796

50.20923, 15.83277

49.59552, 17.25175