A Study of Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies
Last Updated February 21, 2025
Want to learn how to participate in this trial?
CR109124
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 11 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to determine the recommended Phase 2 dose (RP2D) candidate(s) of bleximenib in combination with AML directed therapies (dose selection) and further to evaluate safety and tolerability of bleximenib in combination with AML directed therapies at the RP2D(s) (dose expansion).
CONDITIONS
- Leukemia, Myeloid, Acute
ELIGIBILITY
Inclusion Criteria:
* Diagnosis of AML according to World Health Organization (WHO) criteria: a) De novo or secondary AML; b) relapsed /refractory (Arm A only); c) harboring NPM1 / KMT2A alterations
* Pretreatment clinical laboratory values meeting the following criteria -listed
DETAILS
LOCATIONS
| Country (7) | City or Province (30) | Status |
| United States | Birmingham The University of Alabama at Birmingham |
RECRUITING
|
| United States | Duarte City of Hope |
RECRUITING
|
| United States | Boston Massachusetts General Hospital |
RECRUITING
|
| United States | New York Albert Einstein College Of Medicine |
RECRUITING
|
| United States | Charlotte Novant Health |
RECRUITING
|
| United States | Winston-Salem Novant Health Forsyth Medical Center |
RECRUITING
|
| United States | Houston MD Anderson |
RECRUITING
|
| Australia | Clayton Monash Medical Centre |
RECRUITING
|
| Australia | Melbourne Peter MacCallum Cancer Centre |
RECRUITING
|
| Australia | Westmead Westmead Hospital |
RECRUITING
|
| France | Marseille Cedex 9 Institut Paoli Calmettes |
RECRUITING
|
| France | Toulouse Cedex 9 Institut Universitaire du Cancer Toulouse Oncopole |
RECRUITING
|
| France | Tours CHU de Tours - Hôpital de Bretonneau |
RECRUITING
|
| Germany | Berlin Charite Universitatsmedizin Berlin |
RECRUITING
|
| Germany | Dresden Universitatsklinikum Carl Gustav Carus Dresden |
RECRUITING
|
| Germany | Heidelberg Universitaetsklinikum Heidelberg |
RECRUITING
|
| Germany | Leipzig Universitaetsklinikum Leipzig |
RECRUITING
|
| Germany | Ulm Universitatsklinikum Ulm |
RECRUITING
|
| Italy | Bologna Azienda Opedaliero-Universitaria Policlinico Sant'orsola Malpighi di Bologna |
RECRUITING
|
| Italy | Meldola Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori |
RECRUITING
|
| Italy | Milano ASST Grande Ospedale Metropolitano Niguarda |
RECRUITING
|
| Italy | Rozzano IRCCS Istituto Clinico Humanitas |
RECRUITING
|
| Spain | Barcelona Hosp. de La Santa Creu I Sant Pau |
RECRUITING
|
| Spain | Barcelona Hosp Clinic de Barcelona |
RECRUITING
|
| Spain | Barcelona Hosp Univ Vall D Hebron |
RECRUITING
|
| Spain | Madrid Hosp Univ Fund Jimenez Diaz |
RECRUITING
|
| Spain | Pamplona Clinica Univ. de Navarra |
RECRUITING
|
| United Kingdom | London University College London Hospitals NHSFT |
RECRUITING
|
| United Kingdom | Manchester Christie Hospital NHS Trust |
RECRUITING
|
| United Kingdom | Oxfordshire Oxford University Hospitals NHS Trust |
RECRUITING
|
33.52066, -86.80249
34.13945, -117.97729
42.35843, -71.05977
40.71427, -74.00597
35.22709, -80.84313
36.09986, -80.24422
29.76328, -95.36327
-37.91667, 145.11667
-37.814, 144.96332
-33.80383, 150.98768
43.29551, 5.38958
43.60426, 1.44367
47.38333, 0.68333
52.52437, 13.41053
51.05089, 13.73832
49.40768, 8.69079
51.33962, 12.37129
48.39841, 9.99155
44.49381, 11.33875
44.12775, 12.0626
45.46427, 9.18951
45.38193, 9.1559
41.38879, 2.15899
41.38879, 2.15899
41.38879, 2.15899
40.4165, -3.70256
42.81687, -1.64323
51.50853, -0.12574
53.48095, -2.23743
51.750337, -1.2146896
Indicates 50+ sites in this region: click to zoom in.
Indicates 10+ sites in this region: click to zoom in.
Indicates < 10 sites in this region: click to zoom in.
Corresponds to individual site.