A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer (PolyDamas)
Last Updated April 25, 2025
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CR109323
OVERVIEW
-
Sexes Eligible for Study
all -
Age
years -
Phase
phase 1 -
Sites
Sites -
Status
Recruiting
SUMMARY
The purpose of this study is to identify the recommended Phase 2 (combination) dose (RP2CD) of the amivantamab and cetrelimab combination therapy in participants with non-small cell lung cancer (NSCLC) in Phase 1 (combination dose selection); and to evaluate the antitumor effect of the combination at the selected RP2CD in participants with NSCLC characterized on the basis of epidermal growth factor receptor (EGFR) and Programmed-cell death Ligand (PD-L)1 status, in the Phase 2 (expansion).
CONDITIONS
- Carcinoma, Non-Small-Cell Lung
ELIGIBILITY
Inclusion Criteria:
* Participant must have histologically or cytologically confirmed non-small cell lung cancer (NSCLC) (any histology), and must have metastatic NSCLC at the time of enrollment: Phase 1 (Combination Dose Selection) Cohort; Metastatic NSCLC progressed on or after st
DETAILS
LOCATIONS
| Country (9) | City or Province (41) | Status |
| United States | Los Alamitos Cancer and Blood Specialty Clinic |
RECRUITING
|
| United States | Portland Providence Portland Medical Center |
RECRUITING
|
| United States | Portland Providence Oncology and Hematology Care Clinic Westside |
RECRUITING
|
| United States | Fairfax Virginia Cancer Specialists |
RECRUITING
|
| Brazil | Sao Paulo Fundacao Antonio Prudente A C Camargo Cancer Center |
RECRUITING
|
| South Korea | Seoul Seoul National University Hospital |
RECRUITING
|
| South Korea | Seoul Severance Hospital Yonsei University Health System |
RECRUITING
|
| South Korea | Seoul Samsung Medical Center |
RECRUITING
|
| Malaysia | Kuala Lumpur University Malaya Medical Centre |
RECRUITING
|
| Malaysia | Kuching Hospital Umum Sarawak |
RECRUITING
|
| Türkiye | Ankara Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital |
RECRUITING
|
| United States | Duarte City of Hope |
RECRUITING
|
| United States | Irvine City of Hope Orange County Lennar Foundation Cancer Center |
RECRUITING
|
| Brazil | Barretos Fundacao Pio XII |
RECRUITING
|
| Brazil | Belo Horizonte Cetus Oncologia |
RECRUITING
|
| Brazil | Curitiba CIONC Centro Integrado de Oncologia de Curitiba |
RECRUITING
|
| Italy | Milano European Institute of Oncology |
RECRUITING
|
| Italy | Verona Centro Ricerche Cliniche di Verona S r l |
RECRUITING
|
| Poland | Lublin INSTYTUT GENETYKI I IMMUNOLOGII GENIM Sp z o o |
RECRUITING
|
| Türkiye | Cankaya Ankara Bilkent City Hospital |
COMPLETED
|
| Türkiye | Istanbul Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi |
RECRUITING
|
| Türkiye | Sakarya Sakarya University Training and Research Hospital |
RECRUITING
|
| United States | Houston MD Anderson Cancer Center |
RECRUITING
|
| Brazil | Belo Horizonte PERSONAL Oncologia de Precisao e Personalizada |
RECRUITING
|
| Brazil | Londrina Hospital do Cancer de Londrina |
RECRUITING
|
| Brazil | Porto Alegre Hospital Nossa Senhora da Conceicao S A |
RECRUITING
|
| Brazil | Salvador Hospital Santa Izabel Santa Casa de Misericordia da Bahia |
RECRUITING
|
| Italy | Milano ASST Grande Ospedale Metropolitano Niguarda |
RECRUITING
|
| Italy | Orbassano Aou San Luigi Gonzaga |
RECRUITING
|
| Poland | Poznan Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow |
RECRUITING
|
| Poland | Warszawa Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy |
RECRUITING
|
| Spain | Alicante Hosp. Gral. Univ. de Alicante |
RECRUITING
|
| Spain | Barcelona Hosp Univ Vall D Hebron |
RECRUITING
|
| Spain | Barcelona Hosp. Univ. Quiron Dexeus |
RECRUITING
|
| Spain | Madrid Hosp. Univ. 12 de Octubre |
RECRUITING
|
| Spain | Sevilla Hosp. Virgen Macarena |
RECRUITING
|
| Spain | Valencia Instituto Valenciano de Oncologia |
RECRUITING
|
| Türkiye | Ankara Ankara Bilkent City Hospital |
RECRUITING
|
| United Kingdom | London Imperial College London and Imperial College Healthcare NHS Trust |
RECRUITING
|
| United Kingdom | Newcastle Freeman Hospital |
RECRUITING
|
| United Kingdom | Sutton Royal Marsden Hospital |
RECRUITING
|
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